BRMS1L — 26 ClinVar variants
All ClinVar germline BRMS1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
26 Uncertain significance
Full BRMS1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRMS1L p.Arg143His Uncertain significance Single submitter
- BRMS1L p.Arg143Pro Uncertain significance Single submitter
- BRMS1L p.Arg255Ile Uncertain significance Single submitter
- BRMS1L p.Arg58Ile Uncertain significance Single submitter
- BRMS1L p.Asn13Ser Uncertain significance Single submitter
- BRMS1L p.Asp264Ala Uncertain significance Single submitter
- BRMS1L p.Cys275Gly Uncertain significance Single submitter
- BRMS1L p.Gln272Pro Uncertain significance Single submitter
- BRMS1L p.Glu169Gln Uncertain significance Single submitter
- BRMS1L p.Glu26Gly Uncertain significance Single submitter
- BRMS1L p.Gly316Arg Uncertain significance Single submitter
- BRMS1L p.Lys200Arg Uncertain significance Single submitter
- BRMS1L p.Met231Val Uncertain significance Single submitter
- BRMS1L p.Pro195His Uncertain significance Single submitter
- BRMS1L p.Ser85Asn Uncertain significance Single submitter
- BRMS1L p.Tyr80His Uncertain significance Single submitter
- BRMS1L p.Val239Ala Uncertain significance Single submitter
- BRMS1L p.Val3Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All BRMS1L variants
Uncertain significance 26
- p.Arg143Cys Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg143Pro Single submitter ⚠
- p.Arg255Ile Single submitter ⚠
- p.Arg300Ser Single submitter ⚠
- p.Arg58Ile Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn67Tyr Single submitter
- p.Asp264Ala Single submitter ⚠
- p.Cys275Gly Single submitter ⚠
- p.Gln272Pro Single submitter ⚠
- p.Glu11Ala Single submitter
- p.Glu169Gln Single submitter ⚠
- p.Glu26Gly Single submitter ⚠
- p.Gly265Cys Single submitter
- p.Gly27Arg Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.Lys200Arg Single submitter ⚠
- p.Met231Val Single submitter ⚠
- p.Pro195His Single submitter ⚠
- p.Ser85Asn Single submitter ⚠
- p.Tyr80His Single submitter ⚠
- p.Val204Ala Single submitter ⚠
- p.Val239Ala Single submitter ⚠
- p.Val3Leu Single submitter ⚠