BRS3 — 38 ClinVar variants
All ClinVar germline BRS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
4 Likely benign · 34 Uncertain significance
Full BRS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRS3 p.Asn195Ser Uncertain significance Single submitter
- BRS3 p.Asn40Ser Uncertain significance Single submitter
- BRS3 p.Asp144Asn Uncertain significance Single submitter
- BRS3 p.Asp303Val Uncertain significance Single submitter
- BRS3 p.Asp30Asn Uncertain significance Single submitter
- BRS3 p.Asp39Asn Uncertain significance Single submitter
- BRS3 p.Cys324Trp Uncertain significance Single submitter
- BRS3 p.Gln156Arg Uncertain significance Single submitter
- BRS3 p.Gln344His Uncertain significance Single submitter
- BRS3 p.Glu354Lys Uncertain significance Single submitter
- BRS3 p.Glu45Ala Uncertain significance Single submitter
- BRS3 p.Ile184Val Uncertain significance Single submitter
- BRS3 p.Leu212His Uncertain significance Single submitter
- BRS3 p.Leu330Val Uncertain significance Single submitter
- BRS3 p.Leu96Phe Uncertain significance Single submitter
- BRS3 p.Lys267Asn Uncertain significance Single submitter
- BRS3 p.Met307Val Uncertain significance Single submitter
- BRS3 p.Phe178Val Uncertain significance Single submitter
- BRS3 p.Ser37Arg Uncertain significance Single submitter
- BRS3 p.Ser8Pro Uncertain significance Single submitter
- BRS3 p.Thr300Ala Uncertain significance Single submitter
- BRS3 p.Thr370Ala Uncertain significance Single submitter
- BRS3 p.Val224Leu Uncertain significance Single submitter
- BRS3 p.Val277Ala Uncertain significance Single submitter
- BRS3 p.Val325Ile Uncertain significance Single submitter
- BRS3 p.Val384Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- BRS3 p.Ala319Thr Uncertain significance Single submitter
- BRS3 p.Asn159Ser Uncertain significance Single submitter
- BRS3 p.Cys348Ser Uncertain significance Single submitter
- BRS3 p.Ile216Thr Uncertain significance Single submitter
- BRS3 p.Leu47Ser Uncertain significance Single submitter
- BRS3 p.Phe125Cys Uncertain significance Single submitter
- BRS3 p.Val224Gly Uncertain significance Single submitter
All BRS3 variants
Likely benign 4
- p.Arg192Gln Single submitter
- p.Glu354Asp Single submitter
- p.Thr272= Single submitter
- p.Val171Ile Single submitter
Uncertain significance 34
- p.Ala319Thr Single submitter ⚠
- p.Arg155Ter Single submitter
- p.Asn159Ser Single submitter ⚠
- p.Asn195Ser Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asp144Asn Single submitter ⚠
- p.Asp303Val Single submitter ⚠
- p.Asp30Asn Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Cys324Trp Single submitter ⚠
- p.Cys348Ser Single submitter ⚠
- p.Gln156Arg Single submitter ⚠
- p.Gln344His Single submitter ⚠
- p.Glu354Lys Single submitter ⚠
- p.Glu45Ala Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Leu212His Single submitter ⚠
- p.Leu330Val Single submitter ⚠
- p.Leu47Ser Single submitter ⚠
- p.Leu96Phe Single submitter ⚠
- p.Lys267Asn Single submitter ⚠
- p.Met307Val Single submitter ⚠
- p.Phe125Cys Single submitter ⚠
- p.Phe178Val Single submitter ⚠
- p.Ser37Arg Single submitter ⚠
- p.Ser8Pro Single submitter ⚠
- p.Thr300Ala Single submitter ⚠
- p.Thr370Ala Single submitter ⚠
- p.Val224Gly Single submitter ⚠
- p.Val224Leu Single submitter ⚠
- p.Val277Ala Single submitter ⚠
- p.Val325Ile Single submitter ⚠
- p.Val384Met Single submitter ⚠