BSPRY — 88 ClinVar variants
All ClinVar germline BSPRY variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
5 Likely benign · 83 Uncertain significance
Full BSPRY gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BSPRY p.Gly373Ser Uncertain significance Multiple submitters
- BSPRY p.Ala261Pro Uncertain significance Single submitter
- BSPRY p.Ala287Gly Uncertain significance Single submitter
- BSPRY p.Ala287Ser Uncertain significance Single submitter
- BSPRY p.Ala45Gly Uncertain significance Single submitter
- BSPRY p.Ala82Val Uncertain significance Single submitter
- BSPRY p.Arg138Pro Uncertain significance Single submitter
- BSPRY p.Arg210Gln Uncertain significance Single submitter
- BSPRY p.Arg233Gln Uncertain significance Single submitter
- BSPRY p.Arg237Lys Uncertain significance Single submitter
- BSPRY p.Arg309His Uncertain significance Single submitter
- BSPRY p.Arg317Cys Uncertain significance Single submitter
- BSPRY p.Arg317His Uncertain significance Single submitter
- BSPRY p.Arg55Gly Uncertain significance Single submitter
- BSPRY p.Arg57Cys Uncertain significance Single submitter
- BSPRY p.Arg58Leu Uncertain significance Single submitter
- BSPRY p.Arg58Pro Uncertain significance Single submitter
- BSPRY p.Asn339Ser Uncertain significance Single submitter
- BSPRY p.Cys262Phe Uncertain significance Single submitter
- BSPRY p.Cys44Phe Uncertain significance Single submitter
- BSPRY p.Gln27Arg Uncertain significance Single submitter
- BSPRY p.Glu191Lys Uncertain significance Single submitter
- BSPRY p.Glu343Gln Uncertain significance Single submitter
- BSPRY p.Gly311Asp Uncertain significance Single submitter
- BSPRY p.Gly355Arg Uncertain significance Single submitter
- BSPRY p.Gly355Asp Uncertain significance Single submitter
- BSPRY p.Gly94Ala Uncertain significance Single submitter
- BSPRY p.Leu217Val Uncertain significance Single submitter
- BSPRY p.Lys69Glu Uncertain significance Single submitter
- BSPRY p.Met102Ile Uncertain significance Single submitter
- BSPRY p.Ser101Asn Uncertain significance Single submitter
- BSPRY p.Ser119Arg Uncertain significance Single submitter
- BSPRY p.Thr220Met Uncertain significance Single submitter
- BSPRY p.Thr85Asn Uncertain significance Single submitter
- BSPRY p.Trp325Ser Uncertain significance Single submitter
- BSPRY p.Tyr330Phe Uncertain significance Single submitter
- BSPRY p.Val110Ile Uncertain significance Single submitter
- BSPRY p.Val290Ala Uncertain significance Single submitter
- BSPRY p.Val401Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- BSPRY p.Ala287Val Uncertain significance Single submitter
- BSPRY p.Arg113Trp Uncertain significance Single submitter
- BSPRY p.Arg127Trp Uncertain significance Single submitter
- BSPRY p.Arg138Trp Uncertain significance Single submitter
- BSPRY p.Arg161Cys Uncertain significance Single submitter
- BSPRY p.Arg233Trp Uncertain significance Single submitter
- BSPRY p.Arg268Cys Uncertain significance Single submitter
- BSPRY p.Arg329Cys Uncertain significance Single submitter
- BSPRY p.Arg329His Uncertain significance Single submitter
- BSPRY p.Arg349Trp Uncertain significance Single submitter
- BSPRY p.Arg52Trp Uncertain significance Single submitter
- BSPRY p.Asn274Ser Uncertain significance Single submitter
- BSPRY p.Asp231Val Uncertain significance Single submitter
- BSPRY p.Asp235Asn Uncertain significance Single submitter
- BSPRY p.Asp72Glu Uncertain significance Single submitter
- BSPRY p.Gln363Lys Uncertain significance Single submitter
- BSPRY p.Glu137Lys Uncertain significance Single submitter
- BSPRY p.Glu180Gly Uncertain significance Single submitter
- BSPRY p.Glu24Asp Uncertain significance Single submitter
- BSPRY p.Gly13Arg Uncertain significance Single submitter
- BSPRY p.Gly15Trp Uncertain significance Single submitter
- BSPRY p.Gly17Glu Likely benign Single submitter
- BSPRY p.Gly340Arg Uncertain significance Single submitter
- BSPRY p.Gly385Arg Uncertain significance Single submitter
- BSPRY p.Gly385Glu Uncertain significance Single submitter
- BSPRY p.Gly49Arg Uncertain significance Single submitter
- BSPRY p.His140Pro Uncertain significance Single submitter
- BSPRY p.His338Tyr Uncertain significance Single submitter
- BSPRY p.Leu21Phe Uncertain significance Single submitter
- BSPRY p.Leu29Arg Uncertain significance Single submitter
- BSPRY p.Leu29Val Uncertain significance Single submitter
- BSPRY p.Leu376Phe Uncertain significance Single submitter
- BSPRY p.Lys310Gln Uncertain significance Single submitter
- BSPRY p.Pro10Leu Uncertain significance Single submitter
- BSPRY p.Pro18Leu Uncertain significance Single submitter
- BSPRY p.Pro344Thr Uncertain significance Single submitter
- BSPRY p.Pro93Leu Uncertain significance Single submitter
- BSPRY p.Ser199Leu Uncertain significance Single submitter
- BSPRY p.Ser295Thr Uncertain significance Single submitter
- BSPRY p.Ser312Phe Uncertain significance Single submitter
- BSPRY p.Thr145Ile Uncertain significance Single submitter
- BSPRY p.Thr256Ile Uncertain significance Single submitter
- BSPRY p.Tyr298Cys Uncertain significance Single submitter
- BSPRY p.Val381Met Uncertain significance Single submitter
- BSPRY p.Val401Ala Uncertain significance Single submitter
All BSPRY variants
Likely benign 5
- p.Ala261Thr Single submitter
- p.Gly17Glu Single submitter ⚠
- p.Met102Thr Single submitter
- p.Phe204= Single submitter
- p.Val357Leu Single submitter
Uncertain significance 83
- p.Gly373Ser Multiple submitters ⚠
- p.Ala261Pro Single submitter ⚠
- p.Ala287Gly Single submitter ⚠
- p.Ala287Ser Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala45Gly Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg113Trp Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg138Pro Single submitter ⚠
- p.Arg138Trp Single submitter ⚠
- p.Arg161Cys Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg233Gln Single submitter ⚠
- p.Arg233Trp Single submitter ⚠
- p.Arg237Lys Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg309His Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg329His Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Arg55Gly Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg58Leu Single submitter ⚠
- p.Arg58Pro Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asn339Ser Single submitter ⚠
- p.Asp231Val Single submitter ⚠
- p.Asp235Asn Single submitter ⚠
- p.Asp72Glu Single submitter ⚠
- p.Cys262Phe Single submitter ⚠
- p.Cys44Phe Single submitter ⚠
- p.Gln27Arg Single submitter ⚠
- p.Gln363Lys Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Glu180Gly Single submitter ⚠
- p.Glu191Lys Single submitter ⚠
- p.Glu24Asp Single submitter ⚠
- p.Glu343Gln Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly15Trp Single submitter ⚠
- p.Gly311Asp Single submitter ⚠
- p.Gly340Arg Single submitter ⚠
- p.Gly355Arg Single submitter ⚠
- p.Gly355Asp Single submitter ⚠
- p.Gly385Arg Single submitter ⚠
- p.Gly385Glu Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.Gly94Ala Single submitter ⚠
- p.His140Pro Single submitter ⚠
- p.His338Tyr Single submitter ⚠
- p.Leu217Val Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Leu29Arg Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Leu376Phe Single submitter ⚠
- p.Lys310Gln Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met102Ile Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro344Thr Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser101Asn Single submitter ⚠
- p.Ser119Arg Single submitter ⚠
- p.Ser199Leu Single submitter ⚠
- p.Ser295Thr Single submitter ⚠
- p.Ser312Phe Single submitter ⚠
- p.Thr145Ile Single submitter ⚠
- p.Thr220Met Single submitter ⚠
- p.Thr256Ile Single submitter ⚠
- p.Thr85Asn Single submitter ⚠
- p.Trp325Ser Single submitter ⚠
- p.Tyr298Cys Single submitter ⚠
- p.Tyr330Phe Single submitter ⚠
- p.Val110Ile Single submitter ⚠
- p.Val290Ala Single submitter ⚠
- p.Val381Met Single submitter ⚠
- p.Val401Ala Single submitter ⚠
- p.Val401Ile Single submitter ⚠