BTBD16 — 92 ClinVar variants
All ClinVar germline BTBD16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
12 Likely benign · 80 Uncertain significance
Full BTBD16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BTBD16 p.Ala113Val Uncertain significance Single submitter
- BTBD16 p.Ala161Thr Uncertain significance Single submitter
- BTBD16 p.Ala204Asp Uncertain significance Single submitter
- BTBD16 p.Ala362Thr Uncertain significance Single submitter
- BTBD16 p.Ala505Val Uncertain significance Single submitter
- BTBD16 p.Arg13Cys Uncertain significance Single submitter
- BTBD16 p.Arg197Ser Uncertain significance Single submitter
- BTBD16 p.Arg21Trp Uncertain significance Single submitter
- BTBD16 p.Arg321Lys Uncertain significance Single submitter
- BTBD16 p.Arg443Gln Uncertain significance Single submitter
- BTBD16 p.Asn151Asp Uncertain significance Single submitter
- BTBD16 p.Asp178Val Uncertain significance Single submitter
- BTBD16 p.Asp254Gly Uncertain significance Single submitter
- BTBD16 p.Asp368Asn Uncertain significance Single submitter
- BTBD16 p.Asp374Gly Uncertain significance Single submitter
- BTBD16 p.Cys309Gly Uncertain significance Single submitter
- BTBD16 p.Cys40Tyr Uncertain significance Single submitter
- BTBD16 p.Gln463Arg Uncertain significance Single submitter
- BTBD16 p.Gln95Glu Uncertain significance Single submitter
- BTBD16 p.Glu85Lys Uncertain significance Single submitter
- BTBD16 p.Gly218Ser Uncertain significance Single submitter
- BTBD16 p.Gly229Arg Uncertain significance Single submitter
- BTBD16 p.Gly229Asp Uncertain significance Single submitter
- BTBD16 p.Gly229Ser Uncertain significance Single submitter
- BTBD16 p.Gly242Arg Uncertain significance Single submitter
- BTBD16 p.Gly242Glu Uncertain significance Single submitter
- BTBD16 p.Gly367Asp Uncertain significance Single submitter
- BTBD16 p.Gly88Asp Uncertain significance Single submitter
- BTBD16 p.His411Tyr Uncertain significance Single submitter
- BTBD16 p.His439Asn Uncertain significance Single submitter
- BTBD16 p.His484Arg Uncertain significance Single submitter
- BTBD16 p.His7Pro Uncertain significance Single submitter
- BTBD16 p.His7Tyr Uncertain significance Single submitter
- BTBD16 p.Ile289Thr Uncertain significance Single submitter
- BTBD16 p.Ile332Leu Uncertain significance Single submitter
- BTBD16 p.Ile397Thr Uncertain significance Single submitter
- BTBD16 p.Leu226Pro Uncertain significance Single submitter
- BTBD16 p.Leu283Met Uncertain significance Single submitter
- BTBD16 p.Leu323His Uncertain significance Single submitter
- BTBD16 p.Leu384Met Uncertain significance Single submitter
- BTBD16 p.Leu43Pro Uncertain significance Single submitter
- BTBD16 p.Lys133Arg Uncertain significance Single submitter
- BTBD16 p.Lys136Arg Uncertain significance Single submitter
- BTBD16 p.Lys165Arg Uncertain significance Single submitter
- BTBD16 p.Lys26Glu Uncertain significance Single submitter
- BTBD16 p.Met420Val Uncertain significance Single submitter
- BTBD16 p.Phe160Cys Uncertain significance Single submitter
- BTBD16 p.Phe195Tyr Uncertain significance Single submitter
- BTBD16 p.Phe503Ser Uncertain significance Single submitter
- BTBD16 p.Phe66Ser Uncertain significance Single submitter
- BTBD16 p.Pro119Ser Uncertain significance Single submitter
- BTBD16 p.Pro431Arg Uncertain significance Single submitter
- BTBD16 p.Pro96Ser Uncertain significance Single submitter
- BTBD16 p.Ser170Asn Uncertain significance Single submitter
- BTBD16 p.Ser35Leu Uncertain significance Single submitter
- BTBD16 p.Thr103Ile Uncertain significance Single submitter
- BTBD16 p.Thr117Ala Uncertain significance Single submitter
- BTBD16 p.Thr117Pro Uncertain significance Single submitter
- BTBD16 p.Thr162Met Uncertain significance Single submitter
- BTBD16 p.Thr228Ala Uncertain significance Single submitter
- BTBD16 p.Thr267Ile Uncertain significance Single submitter
- BTBD16 p.Thr478Met Uncertain significance Single submitter
- BTBD16 p.Thr490Ser Uncertain significance Single submitter
- BTBD16 p.Val172Ala Uncertain significance Single submitter
- BTBD16 p.Val199Ala Uncertain significance Single submitter
- BTBD16 p.Val370Phe Uncertain significance Single submitter
-
BTBD16 p.Pro28Ser
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 10
The independent predictors disagree with each other — read with care.
- BTBD16 p.Arg318Trp Uncertain significance Single submitter
- BTBD16 p.Arg446Cys Uncertain significance Single submitter
- BTBD16 p.Gly218Val Uncertain significance Single submitter
- BTBD16 p.Leu194Val Uncertain significance Single submitter
- BTBD16 p.Leu375Arg Uncertain significance Single submitter
- BTBD16 p.Met420Thr Uncertain significance Single submitter
- BTBD16 p.Pro293Leu Uncertain significance Single submitter
- BTBD16 p.Pro322Leu Uncertain significance Single submitter
- BTBD16 p.Ser417Arg Uncertain significance Single submitter
- BTBD16 p.Trp462Cys Uncertain significance Single submitter
All BTBD16 variants
Likely benign 12
- p.Ala433Val Single submitter
- p.Arg314Gln Single submitter
- p.Asp254Glu Single submitter
- p.Glu125Lys Single submitter
- p.Gly242Val Single submitter
- p.Met299Leu Single submitter
- p.Phe67Ser Single submitter
- p.Ser4Leu Single submitter
- p.Thr485Ile Single submitter
- p.Thr6Met Single submitter
- p.Tyr435Cys Single submitter
- p.Val440Ile Single submitter
Uncertain significance 80
- p.Ala113Val Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala204Asp Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala505Val Single submitter ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg197Ser Single submitter ⚠
- p.Arg21Trp Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Arg321Lys Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Asn151Asp Single submitter ⚠
- p.Asp178Val Single submitter ⚠
- p.Asp254Gly Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Asp374Gly Single submitter ⚠
- p.Cys309Gly Single submitter ⚠
- p.Cys40Tyr Single submitter ⚠
- p.Gln463Arg Single submitter ⚠
- p.Gln95Glu Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly218Ser Single submitter ⚠
- p.Gly218Val Single submitter ⚠
- p.Gly229Arg Single submitter ⚠
- p.Gly229Asp Single submitter ⚠
- p.Gly229Ser Single submitter ⚠
- p.Gly242Arg Single submitter ⚠
- p.Gly242Glu Single submitter ⚠
- p.Gly367Asp Single submitter ⚠
- p.Gly367Cys Single submitter
- p.Gly88Asp Single submitter ⚠
- p.His411Tyr Single submitter ⚠
- p.His439Asn Single submitter ⚠
- p.His484Arg Single submitter ⚠
- p.His7Pro Single submitter ⚠
- p.His7Tyr Single submitter ⚠
- p.Ile150Phe Single submitter
- p.Ile289Thr Single submitter ⚠
- p.Ile332Leu Single submitter ⚠
- p.Ile397Thr Single submitter ⚠
- p.Leu167Phe Single submitter
- p.Leu194Val Single submitter ⚠
- p.Leu226Pro Single submitter ⚠
- p.Leu283Met Single submitter ⚠
- p.Leu323His Single submitter ⚠
- p.Leu375Arg Single submitter ⚠
- p.Leu384Met Single submitter ⚠
- p.Leu43Pro Single submitter ⚠
- p.Lys133Arg Single submitter ⚠
- p.Lys136Arg Single submitter ⚠
- p.Lys165Arg Single submitter ⚠
- p.Lys26Glu Single submitter ⚠
- p.Met420Thr Single submitter ⚠
- p.Met420Val Single submitter ⚠
- p.Phe160Cys Single submitter ⚠
- p.Phe195Tyr Single submitter ⚠
- p.Phe503Ser Single submitter ⚠
- p.Phe66Ser Single submitter ⚠
- p.Pro119Ser Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Pro322Leu Single submitter ⚠
- p.Pro431Arg Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser35Leu Single submitter ⚠
- p.Ser417Arg Single submitter ⚠
- p.Thr103Ile Single submitter ⚠
- p.Thr117Ala Single submitter ⚠
- p.Thr117Pro Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr228Ala Single submitter ⚠
- p.Thr267Ile Single submitter ⚠
- p.Thr478Met Single submitter ⚠
- p.Thr490Ser Single submitter ⚠
- p.Trp462Cys Single submitter ⚠
- p.Val172Ala Single submitter ⚠
- p.Val199Ala Single submitter ⚠
- p.Val370Phe Single submitter ⚠
- p.Pro28Ser No assertion criteria prostate cancer ⚠