BTG1 — 16 ClinVar variants

All ClinVar germline BTG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →

1 Likely benign · 15 Uncertain significance

Full BTG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 15

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 11

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 4

The independent predictors disagree with each other — read with care.

All BTG1 variants

Likely benign 1

p.Gln36= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 15

p.Ala18Ser Single submitter ⚠
p.Arg157Lys Single submitter ⚠
p.Arg35Gln Single submitter ⚠
p.Arg35Leu Single submitter ⚠
p.Gln141Glu Single submitter ⚠
p.Ile12Met Single submitter ⚠
p.Ile72Val Single submitter ⚠
p.Pro160Ser Single submitter ⚠
p.Ser133Gly Single submitter ⚠
p.Ser145Asn Single submitter ⚠
p.Ser159Thr Single submitter ⚠
p.Ser23Ala Single submitter ⚠
p.Thr32Met Single submitter ⚠
p.Thr6Pro Single submitter ⚠
p.Val143Leu Single submitter ⚠