BTG2 — 18 ClinVar variants
All ClinVar germline BTG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
3 Likely benign · 15 Uncertain significance
Full BTG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BTG2 p.Arg145Gly Uncertain significance Single submitter
- BTG2 p.Asp8Asn Uncertain significance Single submitter
- BTG2 p.Gly4Arg Uncertain significance Single submitter
- BTG2 p.His3Asp Uncertain significance Single submitter
- BTG2 p.His53Asp Uncertain significance Single submitter
- BTG2 p.Leu134Phe Uncertain significance Single submitter
- BTG2 p.Lys5Asn Uncertain significance Single submitter
- BTG2 p.Val141Met Uncertain significance No assertion criteria
Predictors split 8
The independent predictors disagree with each other — read with care.
- BTG2 p.Gln89Arg Uncertain significance Single submitter
- BTG2 p.Glu125Val Uncertain significance Single submitter
- BTG2 p.Glu32Gln Uncertain significance Single submitter
- BTG2 p.Ile85Asn Uncertain significance Single submitter
- BTG2 p.Pro148Leu Uncertain significance Single submitter
- BTG2 p.Thr26Ile Uncertain significance Single submitter
- BTG2 p.Val121Ile Uncertain significance Single submitter
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BTG2 p.Gln43Pro
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All BTG2 variants
Likely benign 3
- c.142+3G>A No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Gln43Pro No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
- p.Glu44= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 15
- p.Arg145Gly Single submitter ⚠
- p.Asp8Asn Single submitter ⚠
- p.Gln89Arg Single submitter ⚠
- p.Glu125Val Single submitter ⚠
- p.Glu32Gln Single submitter ⚠
- p.Gly4Arg Single submitter ⚠
- p.His3Asp Single submitter ⚠
- p.His53Asp Single submitter ⚠
- p.Ile85Asn Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Lys5Asn Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Thr26Ile Single submitter ⚠
- p.Val121Ile Single submitter ⚠
- p.Val141Met No assertion criteria ⚠