BTG3 — 34 ClinVar variants
All ClinVar germline BTG3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
4 Likely benign · 30 Uncertain significance
Full BTG3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BTG3 p.Arg240Trp Uncertain significance Single submitter
- BTG3 p.Gly200Ser Uncertain significance Single submitter
- BTG3 p.Ile178Thr Uncertain significance Single submitter
- BTG3 p.Lys21Arg Uncertain significance Single submitter
- BTG3 p.Met184Val Uncertain significance Single submitter
- BTG3 p.Phe179Ile Uncertain significance Single submitter
- BTG3 p.Pro170Ala Uncertain significance Single submitter
- BTG3 p.Ser163Leu Uncertain significance Single submitter
- BTG3 p.Val164Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- BTG3 p.Cys99Arg Uncertain significance Single submitter
- BTG3 p.Phe10Val Uncertain significance Single submitter
- BTG3 p.Pro187Ala Uncertain significance Single submitter
- BTG3 p.Pro233Leu Uncertain significance Single submitter
- BTG3 p.Ser116Thr Uncertain significance Single submitter
- BTG3 p.Ser146Ala Uncertain significance Single submitter
- BTG3 p.Thr13Ile Uncertain significance Single submitter
- BTG3 p.Tyr196Cys Uncertain significance Single submitter
All BTG3 variants
Likely benign 4
- c.311+613A>G Single submitter
- c.311+617C>G Single submitter
- c.311+694C>T Single submitter
- c.311+688T>C No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 30
- c.311+603T>C Single submitter
- c.311+622A>G Single submitter
- c.311+624A>G Single submitter
- c.311+632C>A Single submitter
- c.311+637T>C Single submitter
- c.311+646C>T Single submitter
- c.311+661A>G Single submitter
- c.311+679G>A Single submitter
- c.311+691G>A Single submitter
- c.311+696G>A Single submitter
- c.311+703C>T Single submitter
- c.311+706T>C Single submitter
- c.311+709T>C Single submitter
- p.Arg240Trp Single submitter ⚠
- p.Cys99Arg Single submitter ⚠
- p.Gly200Ser Single submitter ⚠
- p.Ile178Thr Single submitter ⚠
- p.Lys21Arg Single submitter ⚠
- p.Met184Val Single submitter ⚠
- p.Phe10Val Single submitter ⚠
- p.Phe179Ile Single submitter ⚠
- p.Pro170Ala Single submitter ⚠
- p.Pro187Ala Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Ser116Thr Single submitter ⚠
- p.Ser146Ala Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Thr13Ile Single submitter ⚠
- p.Tyr196Cys Single submitter ⚠
- p.Val164Ala Single submitter ⚠