BTNL8 — 76 ClinVar variants
All ClinVar germline BTNL8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
11 Likely benign · 65 Uncertain significance
Full BTNL8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BTNL8 p.Ala211Val Uncertain significance Single submitter
- BTNL8 p.Ala475Thr Uncertain significance Single submitter
- BTNL8 p.Ala93Val Uncertain significance Single submitter
- BTNL8 p.Arg162Gly Uncertain significance Single submitter
- BTNL8 p.Arg220Ser Uncertain significance Single submitter
- BTNL8 p.Arg497Ser Uncertain significance Single submitter
- BTNL8 p.Asn383Ser Uncertain significance Single submitter
- BTNL8 p.Asp108Asn Uncertain significance Single submitter
- BTNL8 p.Cys415Gly Uncertain significance Single submitter
- BTNL8 p.Cys434Tyr Uncertain significance Single submitter
- BTNL8 p.Gln464Arg Uncertain significance Single submitter
- BTNL8 p.Glu367Gly Uncertain significance Single submitter
- BTNL8 p.Gly347Arg Uncertain significance Single submitter
- BTNL8 p.His234Gln Uncertain significance Single submitter
- BTNL8 p.Ile142Val Uncertain significance Single submitter
- BTNL8 p.Ile231Thr Uncertain significance Single submitter
- BTNL8 p.Leu243Ile Uncertain significance Single submitter
- BTNL8 p.Leu411Gln Uncertain significance Single submitter
- BTNL8 p.Met185Arg Uncertain significance Single submitter
- BTNL8 p.Met500Arg Uncertain significance Single submitter
- BTNL8 p.Met78Leu Uncertain significance Single submitter
- BTNL8 p.Phe60Ser Uncertain significance Single submitter
- BTNL8 p.Pro230Ser Uncertain significance Single submitter
- BTNL8 p.Pro496Thr Uncertain significance Single submitter
- BTNL8 p.Pro79Ser Uncertain significance Single submitter
- BTNL8 p.Ser179Phe Uncertain significance Single submitter
- BTNL8 p.Ser335Gly Uncertain significance Single submitter
- BTNL8 p.Thr463Ser Uncertain significance Single submitter
- BTNL8 p.Trp167Arg Uncertain significance Single submitter
- BTNL8 p.Val221Ile Uncertain significance Single submitter
- BTNL8 p.Val369Met Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- BTNL8 p.Ala283Thr Uncertain significance Single submitter
- BTNL8 p.Ala50Pro Uncertain significance Single submitter
- BTNL8 p.Arg162Trp Uncertain significance Single submitter
- BTNL8 p.Arg359Gln Uncertain significance Single submitter
- BTNL8 p.Arg435Trp Uncertain significance Single submitter
- BTNL8 p.Arg57Gly Uncertain significance Single submitter
- BTNL8 p.Arg96Cys Uncertain significance Single submitter
- BTNL8 p.Asn103Asp Uncertain significance Single submitter
- BTNL8 p.Asp174His Uncertain significance Single submitter
- BTNL8 p.Gln18Arg Uncertain significance Single submitter
- BTNL8 p.Gly158Val Uncertain significance Single submitter
- BTNL8 p.Gly202Arg Uncertain significance Single submitter
- BTNL8 p.Gly246Asp Uncertain significance Single submitter
- BTNL8 p.Gly70Arg Uncertain significance Single submitter
- BTNL8 p.Gly83Asp Uncertain significance Single submitter
- BTNL8 p.Ile407Thr Uncertain significance Single submitter
- BTNL8 p.Ile457Thr Uncertain significance Single submitter
- BTNL8 p.Leu153Phe Uncertain significance Single submitter
- BTNL8 p.Leu243Arg Uncertain significance Single submitter
- BTNL8 p.Leu5Phe Uncertain significance Single submitter
- BTNL8 p.Met208Thr Uncertain significance Single submitter
- BTNL8 p.Met51Val Uncertain significance Single submitter
- BTNL8 p.Phe189Val Uncertain significance Single submitter
- BTNL8 p.Pro456Ser Uncertain significance Single submitter
- BTNL8 p.Ser157Leu Uncertain significance Single submitter
- BTNL8 p.Ser62Gly Likely benign Single submitter
- BTNL8 p.Thr105Ile Uncertain significance Single submitter
- BTNL8 p.Thr296Met Uncertain significance Single submitter
- BTNL8 p.Thr417Ala Uncertain significance Single submitter
- BTNL8 p.Thr492Met Uncertain significance Single submitter
- BTNL8 p.Trp159Leu Uncertain significance Single submitter
- BTNL8 p.Val146Ile Likely benign Single submitter
- BTNL8 p.Val191Ala Uncertain significance Single submitter
- BTNL8 p.Val197Ile Uncertain significance Single submitter
- BTNL8 p.Val355Met Uncertain significance Single submitter
- BTNL8 p.Val63Met Uncertain significance Single submitter
All BTNL8 variants
Likely benign 11
- p.Ala267= Multiple submitters
- p.Arg209Gln Single submitter
- p.Arg394His Single submitter
- p.Arg96His Single submitter
- p.His286= Single submitter
- p.Ile97Leu Single submitter
- p.Pro299= Single submitter
- p.Ser62Gly Single submitter ⚠
- p.Thr296= Single submitter
- p.Tyr446Cys Single submitter
- p.Val146Ile Single submitter ⚠
Uncertain significance 65
- p.Ala211Val Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala475Thr Single submitter ⚠
- p.Ala50Pro Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg162Gly Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg220Ser Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg435Trp Single submitter ⚠
- p.Arg497Ser Single submitter ⚠
- p.Arg57Gly Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asn103Asp Single submitter ⚠
- p.Asn383Ser Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp174His Single submitter ⚠
- p.Cys415Gly Single submitter ⚠
- p.Cys434Tyr Single submitter ⚠
- p.Gln18Arg Single submitter ⚠
- p.Gln464Arg Single submitter ⚠
- p.Glu367Gly Single submitter ⚠
- p.Gly158Val Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly246Asp Single submitter ⚠
- p.Gly347Arg Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.Gly83Asp Single submitter ⚠
- p.His234Gln Single submitter ⚠
- p.Ile142Val Single submitter ⚠
- p.Ile231Thr Single submitter ⚠
- p.Ile407Thr Single submitter ⚠
- p.Ile457Thr Single submitter ⚠
- p.Leu153Phe Single submitter ⚠
- p.Leu243Arg Single submitter ⚠
- p.Leu243Ile Single submitter ⚠
- p.Leu411Gln Single submitter ⚠
- p.Leu5Phe Single submitter ⚠
- p.Met185Arg Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Met500Arg Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Met78Leu Single submitter ⚠
- p.Phe189Val Single submitter ⚠
- p.Phe60Ser Single submitter ⚠
- p.Pro230Ser Single submitter ⚠
- p.Pro456Ser Single submitter ⚠
- p.Pro496Thr Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Ser157Leu Single submitter ⚠
- p.Ser179Phe Single submitter ⚠
- p.Ser335Gly Single submitter ⚠
- p.Thr105Ile Single submitter ⚠
- p.Thr296Met Single submitter ⚠
- p.Thr417Ala Single submitter ⚠
- p.Thr463Ser Single submitter ⚠
- p.Thr492Met Single submitter ⚠
- p.Trp159Leu Single submitter ⚠
- p.Trp167Arg Single submitter ⚠
- p.Val191Ala Single submitter ⚠
- p.Val197Ile Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val355Met Single submitter ⚠
- p.Val369Met Single submitter ⚠
- p.Val63Met Single submitter ⚠