BTNL9 — 118 ClinVar variants

All ClinVar germline BTNL9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →

6 Benign · 5 Likely benign · 107 Uncertain significance

Full BTNL9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 109

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 50

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 59

The independent predictors disagree with each other — read with care.

All BTNL9 variants

Benign 6

c.853+10C>T Single submitter
p.Asp492= Single submitter
p.Asp519= Single submitter
p.Leu208fs Single submitter
p.Ser126= Single submitter
p.Tyr326= Single submitter

Likely benign 5

p.Arg218Gln Single submitter
p.Ser368= Single submitter
p.Val202Ile Single submitter
p.Val216Ile Single submitter ⚠
p.Val451Ile Single submitter ⚠

Uncertain significance 107

p.Ala144Pro Single submitter ⚠
p.Ala200Val Single submitter ⚠
p.Ala252Val Single submitter ⚠
p.Ala261Thr Single submitter ⚠
p.Ala273Thr Single submitter ⚠
p.Ala291Glu Single submitter ⚠
p.Ala314Thr Single submitter ⚠
p.Ala335Thr Single submitter ⚠
p.Ala360Val Single submitter ⚠
p.Ala404Val Single submitter ⚠
p.Ala439Val Single submitter ⚠
p.Ala481Val Single submitter ⚠
p.Ala531Thr Single submitter ⚠
p.Ala99Pro Single submitter ⚠
p.Ala99Val Single submitter ⚠
p.Arg101Trp Single submitter ⚠
p.Arg134Cys Single submitter ⚠
p.Arg134His Single submitter ⚠
p.Arg313Trp Single submitter ⚠
p.Arg378Gln Single submitter ⚠
p.Arg378Trp Single submitter ⚠
p.Arg393His Single submitter ⚠
p.Arg437Pro Single submitter ⚠
p.Arg447Gly Single submitter ⚠
p.Arg448Cys Single submitter ⚠
p.Arg448His Single submitter ⚠
p.Arg73Cys Single submitter ⚠
p.Arg95Gly Single submitter ⚠
p.Asp110Asn Single submitter ⚠
p.Asp138Asn Single submitter ⚠
p.Asp467Glu Single submitter ⚠
p.Asp533Ala Single submitter ⚠
p.Cys401Ser Single submitter ⚠
p.Cys401Tyr Single submitter ⚠
p.Glu143Lys Single submitter ⚠
p.Glu377Lys Single submitter ⚠
p.Glu456Asp Single submitter ⚠
p.Glu459Asp Single submitter ⚠
p.Glu71Ala Single submitter ⚠
p.Gly129Ser Single submitter ⚠
p.Gly142Ala Single submitter ⚠
p.Gly251Arg Single submitter ⚠
p.Gly316Ala Single submitter ⚠
p.Gly32Glu Single submitter ⚠
p.Gly358Ser Single submitter ⚠
p.Gly450Asp Single submitter ⚠
p.Gly458Glu Single submitter ⚠
p.Gly468Ser Single submitter ⚠
p.Gly493Ser Single submitter ⚠
p.His25Arg Single submitter ⚠
p.His384Arg Single submitter ⚠
p.Ile244Thr Single submitter ⚠
p.Ile47Met Single submitter ⚠
p.Leu277Pro Single submitter ⚠
p.Leu332Pro Single submitter ⚠
p.Leu376Val Single submitter ⚠
p.Leu433Pro Single submitter ⚠
p.Leu442Val Single submitter ⚠
p.Leu500Val Single submitter ⚠
p.Leu65Val Single submitter ⚠
p.Leu85Pro Single submitter ⚠
p.Lys325Thr Single submitter ⚠
p.Met24Ile Single submitter ⚠
p.Pro13Ala Single submitter ⚠
p.Pro264Arg Single submitter ⚠
p.Pro334Gln Single submitter ⚠
p.Pro34Ser Single submitter ⚠
p.Pro356Leu Single submitter ⚠
p.Pro357Arg Single submitter ⚠
p.Pro364Gln Single submitter ⚠
p.Pro364Leu Single submitter ⚠
p.Pro406Leu Single submitter ⚠
p.Pro410Ser Single submitter ⚠
p.Pro415Ser Single submitter ⚠
p.Pro46Ala Single submitter ⚠
p.Pro504Leu Single submitter ⚠
p.Pro524Leu Single submitter ⚠
p.Pro530Leu Single submitter ⚠
p.Pro58Leu Single submitter ⚠
p.Pro98Arg Single submitter ⚠
p.Pro98Leu Single submitter ⚠
p.Ser15Leu Single submitter ⚠
p.Ser340Arg Single submitter ⚠
p.Ser344Leu Single submitter ⚠
p.Ser344Trp Single submitter ⚠
p.Ser352Cys Single submitter ⚠
p.Ser352Phe Single submitter ⚠
p.Ser35Gly Single submitter ⚠
p.Ser35Thr Single submitter ⚠
p.Ser368Trp Single submitter ⚠
p.Ser375Ile Single submitter ⚠
p.Ser414Gly Single submitter ⚠
p.Ser479Leu Single submitter ⚠
p.Ser518Asn Single submitter ⚠
p.Thr17Asn Single submitter ⚠
p.Thr477Ala Single submitter ⚠
p.Thr520Ala Single submitter ⚠
p.Thr520Ser Single submitter ⚠
p.Trp420Arg Single submitter ⚠
p.Val116Met Single submitter ⚠
p.Val184Ile Single submitter ⚠
p.Val21Ala Single submitter ⚠
p.Val227Ile Single submitter ⚠
p.Val276Ile Single submitter ⚠
p.Val350Met Single submitter ⚠
p.Val38Gly Single submitter ⚠
p.Val444Met Single submitter ⚠