BUD31 — 8 ClinVar variants
All ClinVar germline BUD31 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full BUD31 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BUD31 p.Arg58Cys Uncertain significance Single submitter
- BUD31 p.Arg58His Uncertain significance Single submitter
- BUD31 p.Arg8Trp Uncertain significance Single submitter
- BUD31 p.Glu35Gly Uncertain significance Single submitter
- BUD31 p.Ile52Asn Uncertain significance Single submitter
- BUD31 p.Met29Thr Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All BUD31 variants
Uncertain significance 8
- p.Arg58Cys Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Glu35Gly Single submitter ⚠
- p.Ile52Asn Single submitter ⚠
- p.Met29Thr Single submitter ⚠
- p.Tyr65Cys Single submitter ⚠