Sugi Variant

Sugi Variant/C1QC

C1QC — 175 ClinVar variants

All ClinVar germline C1QC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →

2 Pathogenic · 6 Conflicting · 10 Benign · 3 Benign/Likely benign · 75 Likely benign · 79 Uncertain significance

Full C1QC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 63

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 51

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 9

The independent predictors disagree with each other — read with care.

All C1QC variants

Pathogenic 2

Conflicting classifications of pathogenicity 6

Benign 10

Benign/Likely benign 3

Likely benign 75

Uncertain significance 79