C1QL4 — 42 ClinVar variants
All ClinVar germline C1QL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
1 Likely benign · 41 Uncertain significance
Full C1QL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C1QL4 p.Ala114Gly Uncertain significance Single submitter
- C1QL4 p.Ala141Glu Uncertain significance Single submitter
- C1QL4 p.Ala182Asp Uncertain significance Single submitter
- C1QL4 p.Arg109Cys Uncertain significance Single submitter
- C1QL4 p.Arg38His Uncertain significance Single submitter
- C1QL4 p.Arg38Leu Uncertain significance Single submitter
- C1QL4 p.Asp33Glu Uncertain significance Single submitter
- C1QL4 p.Asp43Glu Uncertain significance Single submitter
- C1QL4 p.Glu121Asp Uncertain significance Single submitter
- C1QL4 p.Glu209Lys Uncertain significance Single submitter
- C1QL4 p.Gly122Ser Uncertain significance Single submitter
- C1QL4 p.Gly167Ala Uncertain significance Single submitter
- C1QL4 p.Gly85Arg Uncertain significance Single submitter
- C1QL4 p.Gly88Val Uncertain significance Single submitter
- C1QL4 p.His35Arg Uncertain significance Single submitter
- C1QL4 p.Ile212Val Uncertain significance Single submitter
- C1QL4 p.Leu3Val Uncertain significance Single submitter
- C1QL4 p.Pro10Arg Uncertain significance Single submitter
- C1QL4 p.Pro37Ser Uncertain significance Single submitter
- C1QL4 p.Pro53Ser Uncertain significance Single submitter
- C1QL4 p.Pro97Ser Uncertain significance Single submitter
- C1QL4 p.Ser199Arg Uncertain significance Single submitter
- C1QL4 p.Val100Leu Uncertain significance Single submitter
- C1QL4 p.Val132Gly Uncertain significance Single submitter
- C1QL4 p.Val13Ala Uncertain significance Single submitter
- C1QL4 p.Val153Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- C1QL4 p.Ala114Val Uncertain significance Single submitter
- C1QL4 p.Arg17His Uncertain significance Single submitter
- C1QL4 p.Arg78Lys Uncertain significance Single submitter
- C1QL4 p.Gly164Cys Uncertain significance Single submitter
- C1QL4 p.Gly164Ser Uncertain significance Single submitter
- C1QL4 p.Gly178Arg Uncertain significance Single submitter
- C1QL4 p.Gly99Arg Uncertain significance Single submitter
- C1QL4 p.Pro149Ser Uncertain significance Single submitter
- C1QL4 p.Pro53Arg Uncertain significance Single submitter
- C1QL4 p.Pro71Thr Uncertain significance Single submitter
- C1QL4 p.Pro75Arg Uncertain significance Single submitter
- C1QL4 p.Pro80His Uncertain significance Single submitter
- C1QL4 p.Pro89Ala Uncertain significance Single submitter
- C1QL4 p.Pro90Gln Uncertain significance Single submitter
- C1QL4 p.Ser143Gly Uncertain significance Single submitter
All C1QL4 variants
Likely benign 1
- p.Pro50Ser Single submitter
Uncertain significance 41
- p.Ala114Gly Single submitter ⚠
- p.Ala114Val Single submitter ⚠
- p.Ala141Glu Single submitter ⚠
- p.Ala182Asp Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg38His Single submitter ⚠
- p.Arg38Leu Single submitter ⚠
- p.Arg78Lys Single submitter ⚠
- p.Asp33Glu Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly164Cys Single submitter ⚠
- p.Gly164Ser Single submitter ⚠
- p.Gly167Ala Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly85Arg Single submitter ⚠
- p.Gly88Val Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His35Arg Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Leu3Val Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro53Arg Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Pro71Thr Single submitter ⚠
- p.Pro75Arg Single submitter ⚠
- p.Pro80His Single submitter ⚠
- p.Pro89Ala Single submitter ⚠
- p.Pro90Gln Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser143Gly Single submitter ⚠
- p.Ser199Arg Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val132Gly Single submitter ⚠
- p.Val13Ala Single submitter ⚠
- p.Val153Ile Single submitter ⚠