C1QTNF4 — 80 ClinVar variants
All ClinVar germline C1QTNF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Likely benign · 79 Uncertain significance
Full C1QTNF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C1QTNF4 p.Ala103Glu Uncertain significance Single submitter
- C1QTNF4 p.Ala118Val Uncertain significance Single submitter
- C1QTNF4 p.Ala146Thr Uncertain significance Single submitter
- C1QTNF4 p.Ala158Pro Uncertain significance Single submitter
- C1QTNF4 p.Ala166Gly Uncertain significance Single submitter
- C1QTNF4 p.Ala296Thr Uncertain significance Single submitter
- C1QTNF4 p.Arg110Gln Uncertain significance Single submitter
- C1QTNF4 p.Arg115Gln Uncertain significance Single submitter
- C1QTNF4 p.Arg176Cys Uncertain significance Single submitter
- C1QTNF4 p.Arg185Gly Uncertain significance Single submitter
- C1QTNF4 p.Arg224Cys Uncertain significance Single submitter
- C1QTNF4 p.Glu174Val Uncertain significance Single submitter
- C1QTNF4 p.Gly113Ala Uncertain significance Single submitter
- C1QTNF4 p.Gly138Ser Uncertain significance Single submitter
- C1QTNF4 p.Gly145Ser Uncertain significance Single submitter
- C1QTNF4 p.Gly262Arg Uncertain significance Single submitter
- C1QTNF4 p.Gly58Arg Uncertain significance Single submitter
- C1QTNF4 p.Leu144Ile Uncertain significance Single submitter
- C1QTNF4 p.Leu40Val Uncertain significance Single submitter
- C1QTNF4 p.Lys246Asn Uncertain significance Single submitter
- C1QTNF4 p.Met248Ile Uncertain significance Single submitter
- C1QTNF4 p.Phe230Leu Uncertain significance Single submitter
- C1QTNF4 p.Phe231Val Uncertain significance Single submitter
- C1QTNF4 p.Phe50Leu Uncertain significance Single submitter
- C1QTNF4 p.Pro172Ala Uncertain significance Single submitter
- C1QTNF4 p.Pro200Leu Uncertain significance Single submitter
- C1QTNF4 p.Pro239Leu Uncertain significance Single submitter
- C1QTNF4 p.Ser119Arg Uncertain significance Single submitter
- C1QTNF4 p.Ser186Cys Uncertain significance Single submitter
- C1QTNF4 p.Ser44Leu Uncertain significance Single submitter
- C1QTNF4 p.Ser79Phe Uncertain significance Single submitter
- C1QTNF4 p.Thr131Ala Uncertain significance Single submitter
- C1QTNF4 p.Thr150Ile Uncertain significance Single submitter
- C1QTNF4 p.Tyr157Asp Uncertain significance Single submitter
- C1QTNF4 p.Val208Phe Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- C1QTNF4 p.Ala118Gly Uncertain significance Single submitter
- C1QTNF4 p.Ala12Val Uncertain significance Single submitter
- C1QTNF4 p.Ala13Thr Uncertain significance Single submitter
- C1QTNF4 p.Ala158Val Uncertain significance Single submitter
- C1QTNF4 p.Ala181Gly Uncertain significance Single submitter
- C1QTNF4 p.Ala85Thr Uncertain significance Single submitter
- C1QTNF4 p.Arg176Pro Uncertain significance Single submitter
- C1QTNF4 p.Arg197Trp Uncertain significance Single submitter
- C1QTNF4 p.Arg224His Uncertain significance Single submitter
- C1QTNF4 p.Arg265Trp Uncertain significance Single submitter
- C1QTNF4 p.Asp107Asn Uncertain significance Single submitter
- C1QTNF4 p.Asp159Asn Uncertain significance Single submitter
- C1QTNF4 p.Asp215Ala Uncertain significance Single submitter
- C1QTNF4 p.Asp215Asn Uncertain significance Single submitter
- C1QTNF4 p.Gln102His Uncertain significance Single submitter
- C1QTNF4 p.Glu268Lys Uncertain significance Single submitter
- C1QTNF4 p.Gly129Ser Uncertain significance Single submitter
- C1QTNF4 p.Gly138Asp Uncertain significance Single submitter
- C1QTNF4 p.Gly168Trp Uncertain significance Single submitter
- C1QTNF4 p.Gly193Ser Uncertain significance Single submitter
- C1QTNF4 p.Gly195Val Uncertain significance Single submitter
- C1QTNF4 p.Gly24Arg Uncertain significance Single submitter
- C1QTNF4 p.Gly281Ser Uncertain significance Single submitter
- C1QTNF4 p.Gly295Asp Uncertain significance Single submitter
- C1QTNF4 p.Gly322Cys Uncertain significance Single submitter
- C1QTNF4 p.Gly322Val Uncertain significance Single submitter
- C1QTNF4 p.His137Arg Uncertain significance Single submitter
- C1QTNF4 p.Leu328Val Uncertain significance Single submitter
- C1QTNF4 p.Lys88Gln Uncertain significance Single submitter
- C1QTNF4 p.Pro140Arg Uncertain significance Single submitter
- C1QTNF4 p.Pro165Ser Uncertain significance Single submitter
- C1QTNF4 p.Pro173His Uncertain significance Single submitter
- C1QTNF4 p.Pro175Ala Uncertain significance Single submitter
- C1QTNF4 p.Pro175Thr Uncertain significance Single submitter
- C1QTNF4 p.Pro23Leu Uncertain significance Single submitter
- C1QTNF4 p.Pro86Leu Uncertain significance Single submitter
- C1QTNF4 p.Pro86Ser Uncertain significance Single submitter
- C1QTNF4 p.Ser264Leu Uncertain significance Single submitter
- C1QTNF4 p.Thr38Asn Uncertain significance Single submitter
- C1QTNF4 p.Trp133Arg Uncertain significance Single submitter
- C1QTNF4 p.Tyr142His Uncertain significance Single submitter
- C1QTNF4 p.Val156Leu Uncertain significance Single submitter
- C1QTNF4 p.Val72Met Uncertain significance Single submitter
- C1QTNF4 p.Val92Leu Uncertain significance Single submitter
All C1QTNF4 variants
Likely benign 1
- p.Val63Ala Single submitter
Uncertain significance 79
- p.Ala103Glu Single submitter ⚠
- p.Ala118Gly Single submitter ⚠
- p.Ala118Val Single submitter ⚠
- p.Ala12Val Single submitter ⚠
- p.Ala13Thr Single submitter ⚠
- p.Ala146Thr Single submitter ⚠
- p.Ala158Pro Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala166Gly Single submitter ⚠
- p.Ala181Gly Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg110Gln Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg176Pro Single submitter ⚠
- p.Arg185Gly Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg224Cys Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp159Asn Single submitter ⚠
- p.Asp215Ala Single submitter ⚠
- p.Asp215Asn Single submitter ⚠
- p.Gln102His Single submitter ⚠
- p.Glu174Val Single submitter ⚠
- p.Glu268Lys Single submitter ⚠
- p.Gly113Ala Single submitter ⚠
- p.Gly129Ser Single submitter ⚠
- p.Gly138Asp Single submitter ⚠
- p.Gly138Ser Single submitter ⚠
- p.Gly145Ser Single submitter ⚠
- p.Gly168Trp Single submitter ⚠
- p.Gly193Ser Single submitter ⚠
- p.Gly195Val Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Gly262Arg Single submitter ⚠
- p.Gly281Ser Single submitter ⚠
- p.Gly295Asp Single submitter ⚠
- p.Gly322Cys Single submitter ⚠
- p.Gly322Val Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.Leu144Ile Single submitter ⚠
- p.Leu328Val Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Lys246Asn Single submitter ⚠
- p.Lys88Gln Single submitter ⚠
- p.Met248Ile Single submitter ⚠
- p.Phe230Leu Single submitter ⚠
- p.Phe231Val Single submitter ⚠
- p.Phe50Leu Single submitter ⚠
- p.Pro140Arg Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro172Ala Single submitter ⚠
- p.Pro173His Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro175Thr Single submitter ⚠
- p.Pro200Leu Single submitter ⚠
- p.Pro239Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser119Arg Single submitter ⚠
- p.Ser186Cys Single submitter ⚠
- p.Ser264Leu Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Ser79Phe Single submitter ⚠
- p.Thr131Ala Single submitter ⚠
- p.Thr150Ile Single submitter ⚠
- p.Thr38Asn Single submitter ⚠
- p.Trp133Arg Single submitter ⚠
- p.Tyr142His Single submitter ⚠
- p.Tyr157Asp Single submitter ⚠
- p.Val156Leu Single submitter ⚠
- p.Val208Phe Single submitter ⚠
- p.Val72Met Single submitter ⚠
- p.Val92Leu Single submitter ⚠