C1QTNF6 — 57 ClinVar variants
All ClinVar germline C1QTNF6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 3 Likely benign · 52 Uncertain significance
Full C1QTNF6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C1QTNF6 p.Ala137Thr Uncertain significance Single submitter
- C1QTNF6 p.Ala239Val Uncertain significance Single submitter
- C1QTNF6 p.Ala53Thr Uncertain significance Single submitter
- C1QTNF6 p.Arg150Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg150His Uncertain significance Single submitter
- C1QTNF6 p.Arg226Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg253Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg253His Uncertain significance Single submitter
- C1QTNF6 p.Asn196His Uncertain significance Single submitter
- C1QTNF6 p.Asp278Asn Uncertain significance Single submitter
- C1QTNF6 p.Asp64Glu Uncertain significance Single submitter
- C1QTNF6 p.Gly55Ser Uncertain significance Single submitter
- C1QTNF6 p.His70Arg Uncertain significance Single submitter
- C1QTNF6 p.Ile273Val Uncertain significance Single submitter
- C1QTNF6 p.Ile90Val Uncertain significance Single submitter
- C1QTNF6 p.Leu163Pro Uncertain significance Single submitter
- C1QTNF6 p.Leu36Val Uncertain significance Single submitter
- C1QTNF6 p.Lys274Glu Uncertain significance Single submitter
- C1QTNF6 p.Met229Arg Uncertain significance Single submitter
- C1QTNF6 p.Met38Ile Uncertain significance Single submitter
- C1QTNF6 p.Met43Val Uncertain significance Single submitter
- C1QTNF6 p.Phe48Leu Uncertain significance Single submitter
- C1QTNF6 p.Pro42Thr Uncertain significance Single submitter
- C1QTNF6 p.Pro84Ser Uncertain significance Single submitter
- C1QTNF6 p.Ser194Ile Uncertain significance Single submitter
- C1QTNF6 p.Ser233Asn Uncertain significance Single submitter
- C1QTNF6 p.Tyr110Phe Uncertain significance Single submitter
- C1QTNF6 p.Val197Met Uncertain significance Single submitter
- C1QTNF6 p.Val207Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- C1QTNF6 p.Ala145Thr Uncertain significance Single submitter
- C1QTNF6 p.Ala179Pro Uncertain significance Single submitter
- C1QTNF6 p.Ala216Thr Uncertain significance Single submitter
- C1QTNF6 p.Arg142His Uncertain significance Single submitter
- C1QTNF6 p.Arg167Trp Uncertain significance Single submitter
- C1QTNF6 p.Arg188Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg188His Uncertain significance Single submitter
- C1QTNF6 p.Arg243His Uncertain significance Single submitter
- C1QTNF6 p.Arg243Ser Uncertain significance Single submitter
- C1QTNF6 p.Arg251Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg251His Uncertain significance Single submitter
- C1QTNF6 p.Arg7Cys Uncertain significance Single submitter
- C1QTNF6 p.Arg7His Uncertain significance Single submitter
- C1QTNF6 p.Cys59Trp Uncertain significance Single submitter
- C1QTNF6 p.Glu158Lys Uncertain significance Single submitter
- C1QTNF6 p.Glu166Gly Uncertain significance Single submitter
- C1QTNF6 p.Glu225Lys Uncertain significance Single submitter
- C1QTNF6 p.Gly136Ser Likely benign Single submitter
- C1QTNF6 p.Gly181Ser Uncertain significance Single submitter
- C1QTNF6 p.Met229Val Uncertain significance Single submitter
- C1QTNF6 p.Ser199Asn Uncertain significance Single submitter
- C1QTNF6 p.Thr152Met Uncertain significance Single submitter
- C1QTNF6 p.Thr162Met Uncertain significance Single submitter
- C1QTNF6 p.Val28Ile Uncertain significance Single submitter
All C1QTNF6 variants
Likely benign 3
- p.Ala31Val Single submitter
- p.Arg113Lys Single submitter
- p.Gly136Ser Single submitter ⚠
Uncertain significance 52
- p.Ala137Thr Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala179Pro Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala239Val Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg188Cys Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg243Ser Single submitter ⚠
- p.Arg251Cys Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Arg7His Single submitter ⚠
- p.Asn196His Single submitter ⚠
- p.Asp278Asn Single submitter ⚠
- p.Asp64Glu Single submitter ⚠
- p.Cys59Trp Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Gly181Ser Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.His70Arg Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Ile90Val Single submitter ⚠
- p.Leu163Pro Single submitter ⚠
- p.Leu36Val Single submitter ⚠
- p.Lys274Glu Single submitter ⚠
- p.Met229Arg Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met38Ile Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Phe48Leu Single submitter ⚠
- p.Pro42Thr Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Ser194Ile Single submitter ⚠
- p.Ser199Asn Single submitter ⚠
- p.Ser233Asn Single submitter ⚠
- p.Thr152Met Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Tyr110Phe Single submitter ⚠
- p.Val197Met Single submitter ⚠
- p.Val207Met Single submitter ⚠
- p.Val28Ile Single submitter ⚠