C1QTNF8 — 70 ClinVar variants
All ClinVar germline C1QTNF8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely benign · 69 Uncertain significance
Full C1QTNF8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C1QTNF8 p.Ala110Thr Uncertain significance Single submitter
- C1QTNF8 p.Ala111Thr Uncertain significance Single submitter
- C1QTNF8 p.Ala194Glu Uncertain significance Single submitter
- C1QTNF8 p.Ala194Pro Uncertain significance Single submitter
- C1QTNF8 p.Ala249Asp Uncertain significance Single submitter
- C1QTNF8 p.Ala250Thr Uncertain significance Single submitter
- C1QTNF8 p.Arg186Gln Uncertain significance Single submitter
- C1QTNF8 p.Arg199Ser Uncertain significance Single submitter
- C1QTNF8 p.Arg41Gln Uncertain significance Single submitter
- C1QTNF8 p.Arg41Trp Uncertain significance Single submitter
- C1QTNF8 p.Arg60Gln Uncertain significance Single submitter
- C1QTNF8 p.Asn185Lys Uncertain significance Single submitter
- C1QTNF8 p.Asp227His Uncertain significance Single submitter
- C1QTNF8 p.Asp236Tyr Uncertain significance Single submitter
- C1QTNF8 p.Asp51His Uncertain significance Single submitter
- C1QTNF8 p.Gln101His Uncertain significance Single submitter
- C1QTNF8 p.Glu125Asp Uncertain significance Single submitter
- C1QTNF8 p.Glu87Gln Uncertain significance Single submitter
- C1QTNF8 p.Gly100Asp Uncertain significance Single submitter
- C1QTNF8 p.Gly103Trp Uncertain significance Single submitter
- C1QTNF8 p.Gly109Ala Uncertain significance Single submitter
- C1QTNF8 p.Gly20Arg Uncertain significance Single submitter
- C1QTNF8 p.Gly232Cys Uncertain significance Single submitter
- C1QTNF8 p.Gly232Ser Uncertain significance Single submitter
- C1QTNF8 p.Gly70Asp Uncertain significance Single submitter
- C1QTNF8 p.Gly73Cys Uncertain significance Single submitter
- C1QTNF8 p.His171Gln Uncertain significance Single submitter
- C1QTNF8 p.Ile239Val Uncertain significance Single submitter
- C1QTNF8 p.Ile63Met Uncertain significance Single submitter
- C1QTNF8 p.Leu207Pro Uncertain significance Single submitter
- C1QTNF8 p.Lys69Glu Uncertain significance Single submitter
- C1QTNF8 p.Phe138Leu Uncertain significance Single submitter
- C1QTNF8 p.Phe241Cys Uncertain significance Single submitter
- C1QTNF8 p.Pro22Arg Uncertain significance Single submitter
- C1QTNF8 p.Pro35Ser Uncertain significance Single submitter
- C1QTNF8 p.Tyr164Cys Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- C1QTNF8 p.Ala118Thr Uncertain significance Single submitter
- C1QTNF8 p.Ala118Val Uncertain significance Single submitter
- C1QTNF8 p.Ala189Ser Uncertain significance Single submitter
- C1QTNF8 p.Ala190Ser Uncertain significance Single submitter
- C1QTNF8 p.Arg123Gln Uncertain significance Single submitter
- C1QTNF8 p.Arg186Trp Uncertain significance Single submitter
- C1QTNF8 p.Arg187Leu Uncertain significance Single submitter
- C1QTNF8 p.Arg220Cys Uncertain significance Single submitter
- C1QTNF8 p.Arg60Trp Uncertain significance Single submitter
- C1QTNF8 p.Arg78Gln Uncertain significance Single submitter
- C1QTNF8 p.Arg93Trp Uncertain significance Single submitter
- C1QTNF8 p.Asp131Asn Uncertain significance Single submitter
- C1QTNF8 p.Gln195Arg Uncertain significance Single submitter
- C1QTNF8 p.Gln195Lys Uncertain significance Single submitter
- C1QTNF8 p.Glu141Gln Uncertain significance Single submitter
- C1QTNF8 p.Glu177Asp Uncertain significance Single submitter
- C1QTNF8 p.Gly126Cys Uncertain significance Single submitter
- C1QTNF8 p.Gly91Ser Uncertain significance Single submitter
- C1QTNF8 p.Leu11Pro Uncertain significance Single submitter
- C1QTNF8 p.Leu168Val Uncertain significance Single submitter
- C1QTNF8 p.Met183Val Uncertain significance Single submitter
- C1QTNF8 p.Phe165Leu Uncertain significance Single submitter
- C1QTNF8 p.Pro107Ser Uncertain significance Single submitter
- C1QTNF8 p.Pro108Leu Uncertain significance Single submitter
- C1QTNF8 p.Pro19Ser Uncertain significance Single submitter
- C1QTNF8 p.Pro35Leu Uncertain significance Single submitter
- C1QTNF8 p.Pro90Ser Uncertain significance Single submitter
- C1QTNF8 p.Thr178Asn Uncertain significance Single submitter
- C1QTNF8 p.Tyr175Cys Uncertain significance Single submitter
- C1QTNF8 p.Tyr231Ser Uncertain significance Single submitter
- C1QTNF8 p.Val15Met Uncertain significance Single submitter
- C1QTNF8 p.Val163Ala Uncertain significance Single submitter
- C1QTNF8 p.Val77Ile Uncertain significance Single submitter
All C1QTNF8 variants
Likely benign 1
- p.Arg226Gln Single submitter
Uncertain significance 69
- p.Ala110Thr Single submitter ⚠
- p.Ala111Thr Single submitter ⚠
- p.Ala118Thr Single submitter ⚠
- p.Ala118Val Single submitter ⚠
- p.Ala189Ser Single submitter ⚠
- p.Ala190Ser Single submitter ⚠
- p.Ala194Glu Single submitter ⚠
- p.Ala194Pro Single submitter ⚠
- p.Ala249Asp Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg187Leu Single submitter ⚠
- p.Arg199Ser Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg60Trp Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn185Lys Single submitter ⚠
- p.Asp131Asn Single submitter ⚠
- p.Asp227His Single submitter ⚠
- p.Asp236Tyr Single submitter ⚠
- p.Asp51His Single submitter ⚠
- p.Gln101His Single submitter ⚠
- p.Gln195Arg Single submitter ⚠
- p.Gln195Lys Single submitter ⚠
- p.Glu125Asp Single submitter ⚠
- p.Glu141Gln Single submitter ⚠
- p.Glu177Asp Single submitter ⚠
- p.Glu87Gln Single submitter ⚠
- p.Gly100Asp Single submitter ⚠
- p.Gly103Trp Single submitter ⚠
- p.Gly109Ala Single submitter ⚠
- p.Gly126Cys Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly232Cys Single submitter ⚠
- p.Gly232Ser Single submitter ⚠
- p.Gly70Asp Single submitter ⚠
- p.Gly73Cys Single submitter ⚠
- p.Gly91Ser Single submitter ⚠
- p.His171Gln Single submitter ⚠
- p.Ile239Val Single submitter ⚠
- p.Ile63Met Single submitter ⚠
- p.Leu11Pro Single submitter ⚠
- p.Leu168Val Single submitter ⚠
- p.Leu207Pro Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met183Val Single submitter ⚠
- p.Phe138Leu Single submitter ⚠
- p.Phe165Leu Single submitter ⚠
- p.Phe241Cys Single submitter ⚠
- p.Pro107Ser Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro22Arg Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Thr178Asn Single submitter ⚠
- p.Tyr164Cys Single submitter ⚠
- p.Tyr175Cys Single submitter ⚠
- p.Tyr231Ser Single submitter ⚠
- p.Val15Met Single submitter ⚠
- p.Val163Ala Single submitter ⚠
- p.Val77Ile Single submitter ⚠