C1QTNF9 — 54 ClinVar variants
All ClinVar germline C1QTNF9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Likely benign · 51 Uncertain significance
Full C1QTNF9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C1QTNF9 p.Ala106Ser Uncertain significance Single submitter
- C1QTNF9 p.Ala238Val Uncertain significance Single submitter
- C1QTNF9 p.Ala48Val Uncertain significance Single submitter
- C1QTNF9 p.Arg310Ser Uncertain significance Single submitter
- C1QTNF9 p.Arg94Ser Uncertain significance Single submitter
- C1QTNF9 p.Asn37Ser Uncertain significance Single submitter
- C1QTNF9 p.Asp317Tyr Uncertain significance Single submitter
- C1QTNF9 p.Asp54Asn Uncertain significance Single submitter
- C1QTNF9 p.Gln172His Uncertain significance Single submitter
- C1QTNF9 p.Glu230Lys Uncertain significance Single submitter
- C1QTNF9 p.Glu57Lys Uncertain significance Single submitter
- C1QTNF9 p.Gly119Arg Uncertain significance Single submitter
- C1QTNF9 p.Gly185Ala Uncertain significance Single submitter
- C1QTNF9 p.Gly290Ser Uncertain significance Single submitter
- C1QTNF9 p.Gly29Glu Uncertain significance Single submitter
- C1QTNF9 p.Gly47Arg Uncertain significance Single submitter
- C1QTNF9 p.Gly95Arg Uncertain significance Single submitter
- C1QTNF9 p.Gly95Glu Uncertain significance Single submitter
- C1QTNF9 p.His244Tyr Uncertain significance Single submitter
- C1QTNF9 p.His36Gln Uncertain significance Single submitter
- C1QTNF9 p.Ile226Val Uncertain significance Single submitter
- C1QTNF9 p.Lys277Glu Uncertain significance Single submitter
- C1QTNF9 p.Lys296Gln Uncertain significance Single submitter
- C1QTNF9 p.Pro102Ser Uncertain significance Single submitter
- C1QTNF9 p.Pro151Leu Uncertain significance Single submitter
- C1QTNF9 p.Pro58Arg Uncertain significance Single submitter
- C1QTNF9 p.Pro61Leu Uncertain significance Single submitter
- C1QTNF9 p.Ser331Gly Uncertain significance Single submitter
- C1QTNF9 p.Ser332Asn Uncertain significance Single submitter
- C1QTNF9 p.Thr22Asn Uncertain significance Single submitter
- C1QTNF9 p.Thr242Met Uncertain significance Single submitter
- C1QTNF9 p.Thr323Ala Uncertain significance Single submitter
- C1QTNF9 p.Val130Met Uncertain significance Single submitter
- C1QTNF9 p.Val262Leu Uncertain significance Single submitter
- C1QTNF9 p.Val267Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- C1QTNF9 p.Ala287Val Uncertain significance Single submitter
- C1QTNF9 p.Arg178Trp Uncertain significance Single submitter
- C1QTNF9 p.Arg42Ile Uncertain significance Single submitter
- C1QTNF9 p.Arg45Leu Uncertain significance Single submitter
- C1QTNF9 p.Glu75Lys Uncertain significance Single submitter
- C1QTNF9 p.Gly194Arg Uncertain significance Single submitter
- C1QTNF9 p.Gly194Ser Uncertain significance Single submitter
- C1QTNF9 p.Gly298Arg Uncertain significance Single submitter
- C1QTNF9 p.Gly308Arg Uncertain significance Single submitter
- C1QTNF9 p.Phe258Ser Uncertain significance Single submitter
- C1QTNF9 p.Tyr249Cys Uncertain significance Single submitter
All C1QTNF9 variants
Likely benign 3
- p.Ile273Val Single submitter
- p.Leu197Pro Single submitter
- p.Thr169Met Single submitter
Uncertain significance 51
- p.Ala106Ser Single submitter ⚠
- p.Ala238Val Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Arg178Trp Single submitter ⚠
- p.Arg310Ser Single submitter ⚠
- p.Arg42Ile Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Arg94Ser Single submitter ⚠
- p.Asn37Lys Single submitter
- p.Asn37Ser Single submitter ⚠
- p.Asp317Tyr Single submitter ⚠
- p.Asp54Asn Single submitter ⚠
- p.Gln172His Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Glu75Lys Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly185Ala Single submitter ⚠
- p.Gly194Arg Single submitter ⚠
- p.Gly194Ser Single submitter ⚠
- p.Gly290Ser Single submitter ⚠
- p.Gly290Val Single submitter
- p.Gly298Arg Single submitter ⚠
- p.Gly29Glu Single submitter ⚠
- p.Gly308Arg Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.Gly95Glu Single submitter ⚠
- p.His244Tyr Single submitter ⚠
- p.His36Gln Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Lys277Glu Single submitter ⚠
- p.Lys296Gln Single submitter ⚠
- p.Phe258Ser Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Ser331Gly Single submitter ⚠
- p.Ser332Asn Single submitter ⚠
- p.Thr22Asn Single submitter ⚠
- p.Thr242Met Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Tyr249Cys Single submitter ⚠
- p.Val130Met Single submitter ⚠
- p.Val206Leu Single submitter
- p.Val206Met Single submitter
- p.Val262Leu Single submitter ⚠
- p.Val264Leu Single submitter
- p.Val267Ile Single submitter ⚠