C3AR1 — 78 ClinVar variants
All ClinVar germline C3AR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely pathogenic · 2 Benign · 6 Likely benign · 69 Uncertain significance
Full C3AR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C3AR1 p.Ala150Asp Uncertain significance Single submitter
- C3AR1 p.Ala288Asp Uncertain significance Single submitter
- C3AR1 p.Ala6Thr Uncertain significance Single submitter
- C3AR1 p.Arg134Leu Uncertain significance Single submitter
- C3AR1 p.Arg210Lys Uncertain significance Single submitter
- C3AR1 p.Arg340Ser Uncertain significance Single submitter
- C3AR1 p.Asp183Glu Uncertain significance Single submitter
- C3AR1 p.Asp240Gly Uncertain significance Single submitter
- C3AR1 p.Asp263Glu Uncertain significance Single submitter
- C3AR1 p.Asp325Asn Uncertain significance Single submitter
- C3AR1 p.Asp326Glu Uncertain significance Single submitter
- C3AR1 p.Cys145Arg Uncertain significance Single submitter
- C3AR1 p.Cys172Arg Uncertain significance Single submitter
-
C3AR1 p.Cys389Trp
Uncertain significance
Single submitter
C3AR1-related disorder
- C3AR1 p.Gln232Arg Uncertain significance Single submitter
- C3AR1 p.Gly91Arg Uncertain significance Single submitter
- C3AR1 p.His293Tyr Uncertain significance Single submitter
- C3AR1 p.Ile474Val Uncertain significance Single submitter
- C3AR1 p.Leu192Pro Uncertain significance Single submitter
- C3AR1 p.Leu64Phe Uncertain significance Single submitter
- C3AR1 p.Met52Ile Uncertain significance Single submitter
-
C3AR1 p.Phe187Leu
Uncertain significance
Single submitter
C3AR1-related disorder
- C3AR1 p.Phe187Ser Uncertain significance Single submitter
- C3AR1 p.Pro231Thr Uncertain significance Single submitter
- C3AR1 p.Pro237Ser Uncertain significance Single submitter
- C3AR1 p.Pro267His Uncertain significance Single submitter
- C3AR1 p.Pro267Ser Uncertain significance Single submitter
- C3AR1 p.Pro76Ala Uncertain significance Single submitter
- C3AR1 p.Pro89Ser Uncertain significance Single submitter
- C3AR1 p.Ser196Phe Uncertain significance Single submitter
- C3AR1 p.Ser373Arg Uncertain significance Single submitter
- C3AR1 p.Thr227Ser Uncertain significance Single submitter
- C3AR1 p.Thr292Ala Uncertain significance Single submitter
- C3AR1 p.Thr412Ile Uncertain significance Single submitter
- C3AR1 p.Trp129Gly Uncertain significance Single submitter
- C3AR1 p.Tyr393His Uncertain significance Single submitter
- C3AR1 p.Val124Ile Uncertain significance Single submitter
- C3AR1 p.Val201Asp Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- C3AR1 p.Val136Ala Benign Multiple submitters
- C3AR1 p.Val47Gly Benign Multiple submitters
- C3AR1 p.Ala2Val Uncertain significance Single submitter
- C3AR1 p.Ala335Glu Uncertain significance Single submitter
- C3AR1 p.Arg134His Uncertain significance Single submitter
- C3AR1 p.Arg161Trp Uncertain significance Single submitter
- C3AR1 p.Arg54Trp Uncertain significance Single submitter
- C3AR1 p.Asn427Ser Uncertain significance Single submitter
-
C3AR1 p.Glu307Lys
Uncertain significance
Single submitter
C3AR1-related disorder
- C3AR1 p.Glu455Asp Uncertain significance Single submitter
- C3AR1 p.Gly410Val Uncertain significance Single submitter
- C3AR1 p.Leu413Arg Uncertain significance Single submitter
- C3AR1 p.Leu82Phe Uncertain significance Single submitter
- C3AR1 p.Phe111Leu Uncertain significance Single submitter
- C3AR1 p.Phe158Leu Uncertain significance Single submitter
- C3AR1 p.Phe234Cys Uncertain significance Single submitter
- C3AR1 p.Pro332Leu Uncertain significance Single submitter
- C3AR1 p.Pro332Ser Uncertain significance Single submitter
- C3AR1 p.Pro39Thr Uncertain significance Single submitter
- C3AR1 p.Ser10Ala Uncertain significance Single submitter
- C3AR1 p.Ser31Arg Uncertain significance Single submitter
- C3AR1 p.Ser357Asn Uncertain significance Single submitter
- C3AR1 p.Ser5Phe Uncertain significance Single submitter
- C3AR1 p.Ser78Leu Uncertain significance Single submitter
- C3AR1 p.Thr114Ile Uncertain significance Single submitter
- C3AR1 p.Trp416Gly Uncertain significance Single submitter
-
C3AR1 p.Tyr188Cys
Uncertain significance
Single submitter
C3AR1-related disorder
- C3AR1 p.Val159Ala Uncertain significance Single submitter
- C3AR1 p.Val264Met Uncertain significance Single submitter
- C3AR1 p.Val47Leu Uncertain significance Single submitter
-
C3AR1 p.Val383Ala
Uncertain significance
No assertion criteria
prostate cancer
All C3AR1 variants
Likely pathogenic 1
- p.Asp119fs No assertion criteria hemolytic uremic syndrome, atypical, susceptibility to, 1
Benign 2
- p.Val136Ala Multiple submitters ⚠
- p.Val47Gly Multiple submitters ⚠
Likely benign 6
- p.Asn319Ser Single submitter
- p.Asp190Asn Single submitter
- p.Gly42= Single submitter
- p.Ile59Val Single submitter
- p.Tyr90= Single submitter
- p.Leu409= No assertion criteria C3AR1-related disorder
Uncertain significance 69
- c.-8G>A Single submitter C3AR1-related disorder
- p.Ala150Asp Single submitter ⚠
- p.Ala288Asp Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala335Glu Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg134Leu Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg210Lys Single submitter ⚠
- p.Arg340Ser Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Asn427Ser Single submitter ⚠
- p.Asp183Glu Single submitter ⚠
- p.Asp240Gly Single submitter ⚠
- p.Asp263Glu Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Asp326Glu Single submitter ⚠
- p.Cys145Arg Single submitter ⚠
- p.Cys172Arg Single submitter ⚠
- p.Cys389Trp Single submitter C3AR1-related disorder ⚠
- p.Gln232Arg Single submitter ⚠
- p.Glu307Lys Single submitter C3AR1-related disorder ⚠
- p.Glu455Asp Single submitter ⚠
- p.Gly410Val Single submitter ⚠
- p.Gly91Arg Single submitter ⚠
- p.His293Tyr Single submitter ⚠
- p.Ile474Val Single submitter ⚠
- p.Leu192Pro Single submitter ⚠
- p.Leu413Arg Single submitter ⚠
- p.Leu64Phe Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Lys411fs Single submitter C3AR1-related disorder
- p.Met52Ile Single submitter ⚠
- p.Phe111Leu Single submitter ⚠
- p.Phe158Leu Single submitter ⚠
- p.Phe187Leu Single submitter C3AR1-related disorder ⚠
- p.Phe187Ser Single submitter ⚠
- p.Phe234Cys Single submitter ⚠
- p.Pro231Thr Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro267His Single submitter ⚠
- p.Pro267Ser Single submitter ⚠
- p.Pro332Leu Single submitter ⚠
- p.Pro332Ser Single submitter ⚠
- p.Pro39Thr Single submitter ⚠
- p.Pro76Ala Single submitter ⚠
- p.Pro89Ser Single submitter ⚠
- p.Ser10Ala Single submitter ⚠
- p.Ser196Phe Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser357Asn Single submitter ⚠
- p.Ser373Arg Single submitter ⚠
- p.Ser5Phe Single submitter ⚠
- p.Ser78Leu Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr292Ala Single submitter ⚠
- p.Thr412Ile Single submitter ⚠
- p.Trp129Gly Single submitter ⚠
- p.Trp416Gly Single submitter ⚠
- p.Tyr188Cys Single submitter C3AR1-related disorder ⚠
- p.Tyr393His Single submitter ⚠
- p.Val124Ile Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val201Asp Single submitter ⚠
- p.Val264Met Single submitter ⚠
- p.Val47Leu Single submitter ⚠
- p.Val383Ala No assertion criteria prostate cancer ⚠