C5AR2 — 88 ClinVar variants
All ClinVar germline C5AR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Conflicting · 4 Benign · 10 Likely benign · 73 Uncertain significance
Full C5AR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- C5AR2 p.Ala136Thr Uncertain significance Single submitter
- C5AR2 p.Ala199Thr Uncertain significance Single submitter
- C5AR2 p.Ala199Val Uncertain significance Single submitter
- C5AR2 p.Ala264Ser Uncertain significance Single submitter
- C5AR2 p.Ala27Thr Uncertain significance Single submitter
- C5AR2 p.Ala282Ser Uncertain significance Single submitter
- C5AR2 p.Ala282Thr Uncertain significance Single submitter
- C5AR2 p.Ala44Val Uncertain significance Single submitter
- C5AR2 p.Ala57Asp Uncertain significance Single submitter
- C5AR2 p.Arg108Gln Uncertain significance Single submitter
- C5AR2 p.Arg174Gln Uncertain significance Single submitter
- C5AR2 p.Arg183Gln Uncertain significance Single submitter
- C5AR2 p.Arg19His Uncertain significance Single submitter
- C5AR2 p.Arg204Pro Uncertain significance Single submitter
- C5AR2 p.Arg232Gln Uncertain significance Single submitter
- C5AR2 p.Arg271Gln Uncertain significance Single submitter
- C5AR2 p.Asp15Asn Uncertain significance Single submitter
- C5AR2 p.Gln315Arg Uncertain significance Single submitter
- C5AR2 p.Glu197Lys Uncertain significance Single submitter
- C5AR2 p.Ile171Thr Uncertain significance Single submitter
- C5AR2 p.Ile203Leu Uncertain significance Single submitter
- C5AR2 p.Leu184Val Uncertain significance Single submitter
- C5AR2 p.Leu281Phe Uncertain significance Single submitter
- C5AR2 p.Met118Ile Uncertain significance Single submitter
- C5AR2 p.Pro168Leu Uncertain significance Single submitter
- C5AR2 p.Pro288Leu Uncertain significance Single submitter
- C5AR2 p.Pro33Leu Uncertain significance Single submitter
- C5AR2 p.Ser195Arg Uncertain significance Single submitter
- C5AR2 p.Val167Leu Uncertain significance Single submitter
- C5AR2 p.Val21Gly Uncertain significance Single submitter
- C5AR2 p.Val255Ala Uncertain significance Single submitter
- C5AR2 p.Val332Ala Uncertain significance Single submitter
- C5AR2 p.Val337Ala Uncertain significance Single submitter
- C5AR2 p.Val48Leu Uncertain significance Single submitter
- C5AR2 p.Val59Ala Uncertain significance Single submitter
- C5AR2 p.Val68Leu Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- C5AR2 p.Leu299Val Benign Multiple submitters
- C5AR2 p.Ala170Thr Uncertain significance Single submitter
- C5AR2 p.Ala222Thr Conflicting Single submitter
- C5AR2 p.Ala259Val Uncertain significance Single submitter
- C5AR2 p.Ala37Asp Uncertain significance Single submitter
- C5AR2 p.Ala70Val Uncertain significance Single submitter
- C5AR2 p.Ala95Ser Uncertain significance Single submitter
- C5AR2 p.Arg147Gln Uncertain significance Single submitter
- C5AR2 p.Arg147Trp Uncertain significance Single submitter
- C5AR2 p.Arg174Trp Uncertain significance Single submitter
- C5AR2 p.Arg183Trp Uncertain significance Single submitter
- C5AR2 p.Arg204Gln Uncertain significance Single submitter
- C5AR2 p.Arg229Gln Uncertain significance Single submitter
- C5AR2 p.Arg230Cys Uncertain significance Single submitter
- C5AR2 p.Arg300Cys Uncertain significance Single submitter
- C5AR2 p.Arg35His Uncertain significance Single submitter
- C5AR2 p.Arg65Cys Uncertain significance Single submitter
- C5AR2 p.Arg96Cys Uncertain significance Single submitter
- C5AR2 p.Cys219Ser Uncertain significance Single submitter
- C5AR2 p.Cys307Gly Uncertain significance Single submitter
- C5AR2 p.Glu9Lys Uncertain significance Single submitter
- C5AR2 p.Gly192Asp Uncertain significance Single submitter
- C5AR2 p.His75Gln Uncertain significance Single submitter
- C5AR2 p.His75Tyr Uncertain significance Single submitter
- C5AR2 p.Leu124Phe Uncertain significance Single submitter
- C5AR2 p.Leu251Met Uncertain significance Single submitter
- C5AR2 p.Leu290Phe Uncertain significance Single submitter
- C5AR2 p.Phe291Cys Uncertain significance Single submitter
- C5AR2 p.Pro101Gln Uncertain significance Single submitter
- C5AR2 p.Pro168Thr Uncertain significance Single submitter
- C5AR2 p.Pro261Leu Uncertain significance Single submitter
- C5AR2 p.Pro38Leu Uncertain significance Single submitter
- C5AR2 p.Ser320Cys Uncertain significance Single submitter
- C5AR2 p.Ser5Cys Uncertain significance Single submitter
- C5AR2 p.Thr144Met Uncertain significance Single submitter
- C5AR2 p.Thr160Lys Uncertain significance Single submitter
- C5AR2 p.Tyr8His Uncertain significance Single submitter
- C5AR2 p.Val122Ile Uncertain significance Single submitter
- C5AR2 p.Val78Met Uncertain significance Single submitter
All C5AR2 variants
Conflicting classifications of pathogenicity 1
- p.Ala222Thr Single submitter ⚠
Benign 4
- p.His329Arg Multiple submitters
- p.Leu281= Multiple submitters
- p.Leu299Val Multiple submitters ⚠
- p.Ser17= Multiple submitters
Likely benign 10
- p.Ala109Val Single submitter
- p.Ala182Pro Single submitter
- p.Arg19Leu Single submitter
- p.Arg204= Single submitter
- p.Arg232Trp Single submitter
- p.Arg66Gln Single submitter
- p.Gly138Arg Single submitter
- p.Gly150Arg Single submitter
- p.Gly191= Single submitter
- p.Pro38= Single submitter
Uncertain significance 73
- p.Ala136Thr Single submitter ⚠
- p.Ala170Thr Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Ala199Val Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Ala264Ser Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala282Ser Single submitter ⚠
- p.Ala282Thr Single submitter ⚠
- p.Ala37Asp Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala57Asp Single submitter ⚠
- p.Ala70Val Single submitter ⚠
- p.Ala95Ser Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg183Trp Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg204Pro Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg230Cys Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg65Cys Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Cys219Ser Single submitter ⚠
- p.Cys307Gly Single submitter ⚠
- p.Gln315Arg Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly192Asp Single submitter ⚠
- p.His75Gln Single submitter ⚠
- p.His75Tyr Single submitter ⚠
- p.Ile171Thr Single submitter ⚠
- p.Ile203Leu Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Leu184Val Single submitter ⚠
- p.Leu251Met Single submitter ⚠
- p.Leu281Phe Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Met118Ile Single submitter ⚠
- p.Phe291Cys Single submitter ⚠
- p.Pro101Gln Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro168Thr Single submitter ⚠
- p.Pro261Leu Single submitter ⚠
- p.Pro288Leu Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Ser195Arg Single submitter ⚠
- p.Ser320Cys Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Thr144Met Single submitter ⚠
- p.Thr160Lys Single submitter ⚠
- p.Tyr8His Single submitter ⚠
- p.Val122Ile Single submitter ⚠
- p.Val167Leu Single submitter ⚠
- p.Val21Gly Single submitter ⚠
- p.Val255Ala Single submitter ⚠
- p.Val332Ala Single submitter ⚠
- p.Val337Ala Single submitter ⚠
- p.Val48Leu Single submitter ⚠
- p.Val59Ala Single submitter ⚠
- p.Val68Leu Single submitter ⚠
- p.Val78Met Single submitter ⚠