CA10 — 37 ClinVar variants
All ClinVar germline CA10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
37 Uncertain significance
Full CA10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA10 p.Trp250Leu Uncertain significance Multiple submitters
- CA10 p.Ala21Val Uncertain significance Single submitter
- CA10 p.Arg198Gln Uncertain significance Single submitter
- CA10 p.Arg298Cys Uncertain significance Single submitter
- CA10 p.Arg65Gln Uncertain significance Single submitter
- CA10 p.Asn14Ser Uncertain significance Single submitter
- CA10 p.Asp203His Uncertain significance Single submitter
- CA10 p.Cys18Phe Uncertain significance Single submitter
- CA10 p.Gln274Lys Uncertain significance Single submitter
- CA10 p.Glu129Lys Uncertain significance Single submitter
- CA10 p.Glu37Asp Uncertain significance Single submitter
- CA10 p.Gly119Glu Uncertain significance Single submitter
- CA10 p.Gly120Arg Uncertain significance Single submitter
- CA10 p.Gly307Arg Uncertain significance Single submitter
- CA10 p.Gly31Ala Uncertain significance Single submitter
- CA10 p.Gly91Ser Uncertain significance Single submitter
- CA10 p.His104Gln Uncertain significance Single submitter
- CA10 p.His75Tyr Uncertain significance Single submitter
- CA10 p.Ile71Thr Uncertain significance Single submitter
- CA10 p.Leu179Trp Uncertain significance Single submitter
- CA10 p.Ser143Thr Uncertain significance Single submitter
- CA10 p.Thr240Ser Uncertain significance Single submitter
- CA10 p.Thr260Ile Uncertain significance Single submitter
- CA10 p.Thr299Asn Uncertain significance Single submitter
- CA10 p.Val38Glu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CA10 p.Arg127Gln Uncertain significance Single submitter
- CA10 p.Asn116Ser Uncertain significance Single submitter
- CA10 p.Asn201Asp Uncertain significance Single submitter
- CA10 p.Gln277His Uncertain significance Single submitter
- CA10 p.Gly90Glu Uncertain significance Single submitter
- CA10 p.Ile252Val Uncertain significance Single submitter
- CA10 p.Ser281Arg Uncertain significance Single submitter
- CA10 p.Thr167Met Uncertain significance Single submitter
- CA10 p.Thr89Met Uncertain significance Single submitter
- CA10 p.Tyr245Cys Uncertain significance Single submitter
- CA10 p.Val188Ala Uncertain significance Single submitter
- CA10 p.Asp236Asn Uncertain significance No assertion criteria
All CA10 variants
Uncertain significance 37
- p.Trp250Leu Multiple submitters ⚠
- p.Ala21Val Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg298Cys Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Asn116Ser Single submitter ⚠
- p.Asn14Ser Single submitter ⚠
- p.Asn201Asp Single submitter ⚠
- p.Asp203His Single submitter ⚠
- p.Cys18Phe Single submitter ⚠
- p.Gln274Lys Single submitter ⚠
- p.Gln277His Single submitter ⚠
- p.Glu129Lys Single submitter ⚠
- p.Glu37Asp Single submitter ⚠
- p.Gly119Glu Single submitter ⚠
- p.Gly120Arg Single submitter ⚠
- p.Gly307Arg Single submitter ⚠
- p.Gly31Ala Single submitter ⚠
- p.Gly90Glu Single submitter ⚠
- p.Gly91Ser Single submitter ⚠
- p.His104Gln Single submitter ⚠
- p.His75Tyr Single submitter ⚠
- p.Ile252Val Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Leu179Trp Single submitter ⚠
- p.Ser143Thr Single submitter ⚠
- p.Ser281Arg Single submitter ⚠
- p.Thr167Met Single submitter ⚠
- p.Thr240Ser Single submitter ⚠
- p.Thr260Ile Single submitter ⚠
- p.Thr299Asn Single submitter ⚠
- p.Thr89Met Single submitter ⚠
- p.Tyr245Cys Single submitter ⚠
- p.Val188Ala Single submitter ⚠
- p.Val38Glu Single submitter ⚠
- p.Asp236Asn No assertion criteria ⚠