CA11 — 31 ClinVar variants
All ClinVar germline CA11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
31 Uncertain significance
Full CA11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA11 p.Ala139Asp Uncertain significance Single submitter
- CA11 p.Ala143Pro Uncertain significance Single submitter
- CA11 p.Ala191Thr Uncertain significance Single submitter
- CA11 p.Arg289Trp Uncertain significance Single submitter
- CA11 p.Arg318His Uncertain significance Single submitter
- CA11 p.Arg318Leu Uncertain significance Single submitter
- CA11 p.Arg6Pro Uncertain significance Single submitter
- CA11 p.Asp30Glu Uncertain significance Single submitter
- CA11 p.Asp322Glu Uncertain significance Single submitter
- CA11 p.Asp33Asn Uncertain significance Single submitter
- CA11 p.Gly233Ser Uncertain significance Single submitter
- CA11 p.Gly286Ser Uncertain significance Single submitter
- CA11 p.Ile183Val Uncertain significance Single submitter
- CA11 p.Lys213Glu Uncertain significance Single submitter
- CA11 p.Lys76Glu Uncertain significance Single submitter
- CA11 p.Pro123Ser Uncertain significance Single submitter
- CA11 p.Pro325Arg Uncertain significance Single submitter
- CA11 p.Pro325Leu Uncertain significance Single submitter
- CA11 p.Ser185Arg Uncertain significance Single submitter
- CA11 p.Ser8Gly Uncertain significance Single submitter
- CA11 p.Trp252Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CA11 p.Ala63Thr Uncertain significance Single submitter
- CA11 p.Arg209His Uncertain significance Single submitter
- CA11 p.Arg6Cys Uncertain significance Single submitter
- CA11 p.Asp205Asn Uncertain significance Single submitter
- CA11 p.Ile253Val Uncertain significance Single submitter
- CA11 p.Ile255Thr Uncertain significance Single submitter
- CA11 p.Leu269Val Uncertain significance Single submitter
- CA11 p.Ser90Arg Uncertain significance Single submitter
- CA11 p.Thr99Ile Uncertain significance Single submitter
- CA11 p.Val190Ala Uncertain significance Single submitter
All CA11 variants
Uncertain significance 31
- p.Ala139Asp Single submitter ⚠
- p.Ala143Pro Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg289Trp Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg318Leu Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Asp205Asn Single submitter ⚠
- p.Asp30Glu Single submitter ⚠
- p.Asp322Glu Single submitter ⚠
- p.Asp33Asn Single submitter ⚠
- p.Gly233Ser Single submitter ⚠
- p.Gly286Ser Single submitter ⚠
- p.Ile183Val Single submitter ⚠
- p.Ile253Val Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Leu269Val Single submitter ⚠
- p.Lys213Glu Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Pro123Ser Single submitter ⚠
- p.Pro325Arg Single submitter ⚠
- p.Pro325Leu Single submitter ⚠
- p.Ser185Arg Single submitter ⚠
- p.Ser8Gly Single submitter ⚠
- p.Ser90Arg Single submitter ⚠
- p.Thr99Ile Single submitter ⚠
- p.Trp252Cys Single submitter ⚠
- p.Val190Ala Single submitter ⚠