CA9 — 83 ClinVar variants
All ClinVar germline CA9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Benign · 11 Likely benign · 71 Uncertain significance
Full CA9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA9 p.Ala155Thr Uncertain significance Single submitter
- CA9 p.Ala232Val Uncertain significance Single submitter
- CA9 p.Ala300Ser Uncertain significance Single submitter
- CA9 p.Ala377Glu Uncertain significance Single submitter
- CA9 p.Ala425Ser Uncertain significance Single submitter
- CA9 p.Ala430Val Uncertain significance Single submitter
- CA9 p.Ala459Val Uncertain significance Single submitter
- CA9 p.Arg178Leu Uncertain significance Single submitter
- CA9 p.Arg268Leu Uncertain significance Single submitter
- CA9 p.Arg399Gln Uncertain significance Single submitter
- CA9 p.Arg42Gly Uncertain significance Single submitter
- CA9 p.Cys336Trp Uncertain significance Single submitter
- CA9 p.Glu219Asp Uncertain significance Single submitter
- CA9 p.Gly230Arg Uncertain significance Single submitter
- CA9 p.Gly393Arg Uncertain significance Single submitter
- CA9 p.Gly421Arg Uncertain significance Single submitter
- CA9 p.Gly445Ala Uncertain significance Single submitter
- CA9 p.Leu110Ser Uncertain significance Single submitter
- CA9 p.Leu206Pro Uncertain significance Single submitter
- CA9 p.Leu292Ser Uncertain significance Single submitter
- CA9 p.Lys101Arg Uncertain significance Single submitter
- CA9 p.Lys133Gln Uncertain significance Single submitter
- CA9 p.Phe259Leu Uncertain significance Single submitter
- CA9 p.Phe375Leu Uncertain significance Single submitter
- CA9 p.Pro188Ser Uncertain significance Single submitter
- CA9 p.Pro3Leu Uncertain significance Single submitter
- CA9 p.Ser237Leu Uncertain significance Single submitter
- CA9 p.Ser314Thr Uncertain significance Single submitter
- CA9 p.Ser330Phe Uncertain significance Single submitter
- CA9 p.Thr348Ile Uncertain significance Single submitter
- CA9 p.Trp229Leu Uncertain significance Single submitter
- CA9 p.Trp9Arg Uncertain significance Single submitter
- CA9 p.Tyr327His Uncertain significance Single submitter
- CA9 p.Val262Gly Uncertain significance Single submitter
Predictors split 41
The independent predictors disagree with each other — read with care.
- CA9 p.Ala176Val Uncertain significance Single submitter
- CA9 p.Ala300Thr Likely benign Single submitter
- CA9 p.Ala353Thr Uncertain significance Single submitter
- CA9 p.Ala377Val Likely benign Single submitter
- CA9 p.Ala430Thr Uncertain significance Single submitter
- CA9 p.Arg221Gly Uncertain significance Single submitter
- CA9 p.Arg245Cys Uncertain significance Single submitter
- CA9 p.Arg295His Likely benign Single submitter
- CA9 p.Arg323His Uncertain significance Single submitter
- CA9 p.Arg370Gly Uncertain significance Single submitter
- CA9 p.Arg370Trp Uncertain significance Single submitter
- CA9 p.Asn382Ser Uncertain significance Single submitter
- CA9 p.Asp70Tyr Uncertain significance Single submitter
- CA9 p.Asp82Asn Uncertain significance Single submitter
- CA9 p.Asp82Tyr Uncertain significance Single submitter
- CA9 p.Gln161Glu Uncertain significance Single submitter
- CA9 p.Gln438Lys Uncertain significance Single submitter
- CA9 p.Glu105Ala Uncertain significance Single submitter
- CA9 p.Glu181Lys Uncertain significance Single submitter
- CA9 p.Glu456Lys Uncertain significance Single submitter
- CA9 p.Glu62Gln Uncertain significance Single submitter
- CA9 p.Glu62Lys Uncertain significance Single submitter
- CA9 p.Glu69Asp Uncertain significance Single submitter
- CA9 p.Glu69Lys Uncertain significance Single submitter
- CA9 p.Glu75Asp Uncertain significance Single submitter
- CA9 p.Glu86Asp Uncertain significance Single submitter
- CA9 p.Glu87Lys Uncertain significance Single submitter
- CA9 p.Leu32Pro Uncertain significance Single submitter
- CA9 p.Leu418Pro Uncertain significance Single submitter
- CA9 p.Phe345Leu Uncertain significance Single submitter
- CA9 p.Pro179His Uncertain significance Single submitter
- CA9 p.Pro269Leu Uncertain significance Single submitter
- CA9 p.Pro283Leu Uncertain significance Single submitter
- CA9 p.Pro66Leu Uncertain significance Single submitter
- CA9 p.Pro96Ser Uncertain significance Single submitter
- CA9 p.Ser448Asn Uncertain significance Single submitter
- CA9 p.Thr205Ile Uncertain significance Single submitter
- CA9 p.Thr378Met Uncertain significance Single submitter
- CA9 p.Val152Met Uncertain significance Single submitter
- CA9 p.Val385Met Likely benign Single submitter
- CA9 p.Val433Ala Uncertain significance Single submitter
All CA9 variants
Benign 1
- p.Pro114= Multiple submitters
Likely benign 11
- p.Ala300Thr Single submitter ⚠
- p.Ala377Val Single submitter ⚠
- p.Arg295His Single submitter ⚠
- p.Arg42Trp Single submitter
- p.Arg450His Single submitter
- p.Gly120Arg Single submitter
- p.Ile313Val Single submitter
- p.Pro41Ser Single submitter
- p.Ser71Pro Single submitter
- p.Val385Met Single submitter ⚠
- p.Val429Ile Single submitter
Uncertain significance 71
- p.Ala155Thr Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala232Val Single submitter ⚠
- p.Ala300Ser Single submitter ⚠
- p.Ala353Thr Single submitter ⚠
- p.Ala377Glu Single submitter ⚠
- p.Ala425Ser Single submitter ⚠
- p.Ala430Thr Single submitter ⚠
- p.Ala430Val Single submitter ⚠
- p.Ala459Val Single submitter ⚠
- p.Arg178Leu Single submitter ⚠
- p.Arg221Gly Single submitter ⚠
- p.Arg245Cys Single submitter ⚠
- p.Arg268Leu Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg370Gly Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg42Gly Single submitter ⚠
- p.Asn382Ser Single submitter ⚠
- p.Asp70Tyr Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Asp82Tyr Single submitter ⚠
- p.Cys336Trp Single submitter ⚠
- p.Gln161Glu Single submitter ⚠
- p.Gln438Lys Single submitter ⚠
- p.Glu105Ala Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu219Asp Single submitter ⚠
- p.Glu456Lys Single submitter ⚠
- p.Glu62Gln Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Glu69Asp Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Glu75Asp Single submitter ⚠
- p.Glu86Asp Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.Gly393Arg Single submitter ⚠
- p.Gly421Arg Single submitter ⚠
- p.Gly445Ala Single submitter ⚠
- p.Leu110Ser Single submitter ⚠
- p.Leu206Pro Single submitter ⚠
- p.Leu292Ser Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Leu418Pro Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys133Gln Single submitter ⚠
- p.Phe259Leu Single submitter ⚠
- p.Phe345Leu Single submitter ⚠
- p.Phe375Leu Single submitter ⚠
- p.Pro179His Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro269Leu Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser237Leu Single submitter ⚠
- p.Ser314Thr Single submitter ⚠
- p.Ser330Phe Single submitter ⚠
- p.Ser448Asn Single submitter ⚠
- p.Thr205Ile Single submitter ⚠
- p.Thr348Ile Single submitter ⚠
- p.Thr378Met Single submitter ⚠
- p.Trp229Leu Single submitter ⚠
- p.Trp9Arg Single submitter ⚠
- p.Tyr327His Single submitter ⚠
- p.Val152Met Single submitter ⚠
- p.Val262Gly Single submitter ⚠
- p.Val433Ala Single submitter ⚠