CABLES1 — 118 ClinVar variants
All ClinVar germline CABLES1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
1 Conflicting · 6 Likely benign · 111 Uncertain significance
Full CABLES1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CABLES1 p.Ala104Val Uncertain significance Single submitter
- CABLES1 p.Ala114Val Uncertain significance Single submitter
- CABLES1 p.Ala12Pro Uncertain significance Single submitter
- CABLES1 p.Ala12Ser Uncertain significance Single submitter
- CABLES1 p.Ala155Ser Uncertain significance Single submitter
- CABLES1 p.Ala155Val Uncertain significance Single submitter
- CABLES1 p.Ala172Thr Uncertain significance Single submitter
- CABLES1 p.Ala203Ser Uncertain significance Single submitter
- CABLES1 p.Ala213Ser Uncertain significance Single submitter
- CABLES1 p.Ala22Val Uncertain significance Single submitter
- CABLES1 p.Ala25Val Uncertain significance Single submitter
- CABLES1 p.Ala376Gly Uncertain significance Single submitter
- CABLES1 p.Ala549Pro Uncertain significance Single submitter
- CABLES1 p.Ala549Thr Uncertain significance Single submitter
- CABLES1 p.Ala8Thr Uncertain significance Single submitter
- CABLES1 p.Arg116Leu Uncertain significance Single submitter
- CABLES1 p.Arg116Pro Uncertain significance Single submitter
- CABLES1 p.Arg164Pro Uncertain significance Single submitter
- CABLES1 p.Arg254Lys Uncertain significance Single submitter
- CABLES1 p.Arg357Cys Uncertain significance Single submitter
- CABLES1 p.Arg412Gln Uncertain significance Single submitter
- CABLES1 p.Arg431His Uncertain significance Single submitter
- CABLES1 p.Arg437Gln Uncertain significance Single submitter
- CABLES1 p.Arg53Trp Uncertain significance Single submitter
- CABLES1 p.Arg56Leu Uncertain significance Single submitter
- CABLES1 p.Arg60Gln Uncertain significance Single submitter
- CABLES1 p.Arg628Gln Uncertain significance Single submitter
- CABLES1 p.Arg628Trp Uncertain significance Single submitter
- CABLES1 p.Arg77Gly Uncertain significance Single submitter
- CABLES1 p.Asp198Tyr Uncertain significance Single submitter
- CABLES1 p.Asp211Asn Uncertain significance Single submitter
- CABLES1 p.Asp211Gly Uncertain significance Single submitter
- CABLES1 p.Asp368Asn Uncertain significance Single submitter
- CABLES1 p.Asp450Glu Uncertain significance Single submitter
- CABLES1 p.Cys102Trp Uncertain significance Single submitter
- CABLES1 p.Cys13Arg Uncertain significance Single submitter
- CABLES1 p.Cys13Tyr Uncertain significance Single submitter
- CABLES1 p.Gln142Arg Uncertain significance Single submitter
- CABLES1 p.Gln179Arg Uncertain significance Single submitter
- CABLES1 p.Gln181Leu Uncertain significance Single submitter
- CABLES1 p.Gln631Leu Uncertain significance Single submitter
- CABLES1 p.Glu504Ala Uncertain significance Single submitter
- CABLES1 p.Glu619Lys Uncertain significance Single submitter
- CABLES1 p.Glu89Lys Uncertain significance Single submitter
- CABLES1 p.Gly171Asp Uncertain significance Single submitter
- CABLES1 p.Gly19Ser Uncertain significance Single submitter
- CABLES1 p.Gly27Arg Uncertain significance Single submitter
- CABLES1 p.Gly369Arg Uncertain significance Single submitter
- CABLES1 p.Gly88Asp Uncertain significance Single submitter
- CABLES1 p.Gly97Ser Uncertain significance Single submitter
- CABLES1 p.Gly99Ser Uncertain significance Single submitter
- CABLES1 p.Ile120Leu Uncertain significance Single submitter
- CABLES1 p.Ile341Met Uncertain significance Single submitter
- CABLES1 p.Ile383Thr Uncertain significance Single submitter
- CABLES1 p.Ile435Leu Uncertain significance Single submitter
- CABLES1 p.Ile477Val Uncertain significance Single submitter
- CABLES1 p.Leu208Trp Uncertain significance Single submitter
- CABLES1 p.Lys54Gln Uncertain significance Single submitter
- CABLES1 p.Lys95Arg Uncertain significance Single submitter
- CABLES1 p.Lys95Glu Uncertain significance Single submitter
- CABLES1 p.Met455Thr Uncertain significance Single submitter
- CABLES1 p.Phe166Leu Uncertain significance Single submitter
- CABLES1 p.Phe422Leu Uncertain significance Single submitter
- CABLES1 p.Pro125Arg Uncertain significance Single submitter
- CABLES1 p.Pro147Leu Uncertain significance Single submitter
- CABLES1 p.Pro147Ser Uncertain significance Single submitter
- CABLES1 p.Pro151Leu Uncertain significance Single submitter
- CABLES1 p.Pro160Ser Uncertain significance Single submitter
- CABLES1 p.Pro31Gln Uncertain significance Single submitter
- CABLES1 p.Pro35Ser Uncertain significance Single submitter
- CABLES1 p.Pro39Arg Uncertain significance Single submitter
- CABLES1 p.Pro44Arg Uncertain significance Single submitter
- CABLES1 p.Pro507Leu Uncertain significance Single submitter
- CABLES1 p.Pro51Thr Uncertain significance Single submitter
- CABLES1 p.Pro52Arg Uncertain significance Single submitter
- CABLES1 p.Pro52Ser Uncertain significance Single submitter
- CABLES1 p.Pro55Arg Uncertain significance Single submitter
- CABLES1 p.Ser15Gly Uncertain significance Single submitter
- CABLES1 p.Ser168Thr Uncertain significance Single submitter
- CABLES1 p.Ser176Leu Uncertain significance Single submitter
- CABLES1 p.Ser262Phe Uncertain significance Single submitter
- CABLES1 p.Thr272Ser Uncertain significance Single submitter
- CABLES1 p.Tyr626Cys Uncertain significance Single submitter
- CABLES1 p.Val217Met Uncertain significance Single submitter
- CABLES1 p.Val339Ile Uncertain significance Single submitter
- CABLES1 p.Val362Ile Uncertain significance Single submitter
- CABLES1 p.Val489Leu Uncertain significance Single submitter
- CABLES1 p.Val489Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CABLES1 p.Ala527Val Uncertain significance Single submitter
- CABLES1 p.Arg254Met Uncertain significance Single submitter
- CABLES1 p.Arg280Thr Uncertain significance Single submitter
- CABLES1 p.Arg283Trp Uncertain significance Single submitter
- CABLES1 p.Arg524Gln Uncertain significance Single submitter
- CABLES1 p.Arg524Trp Uncertain significance Single submitter
-
CABLES1 p.Arg56Cys
Conflicting
Single submitter
Hereditary cancer
- CABLES1 p.Asp58Asn Uncertain significance Single submitter
- CABLES1 p.Glu210Lys Uncertain significance Single submitter
- CABLES1 p.Glu621Lys Uncertain significance Single submitter
- CABLES1 p.Gly384Arg Uncertain significance Single submitter
- CABLES1 p.Gly387Asp Uncertain significance Single submitter
- CABLES1 p.Ile486Val Uncertain significance Single submitter
- CABLES1 p.Leu615Val Uncertain significance Single submitter
- CABLES1 p.Lys503Arg Uncertain significance Single submitter
- CABLES1 p.Pro37His Uncertain significance Single submitter
- CABLES1 p.Ser492Leu Uncertain significance Single submitter
- CABLES1 p.Ser67Phe Uncertain significance Single submitter
- CABLES1 p.Thr294Ala Uncertain significance Single submitter
- CABLES1 p.Thr501Asn Uncertain significance Single submitter
- CABLES1 p.Val475Ile Uncertain significance Single submitter
All CABLES1 variants
Conflicting classifications of pathogenicity 1
- p.Arg56Cys Single submitter Hereditary cancer ⚠
Likely benign 6
- p.Asp75= Multiple submitters
- p.Glu178Lys Single submitter
- p.Pro80Leu Single submitter
- p.Ser200Pro Single submitter
- p.Ser216Gly Single submitter
- p.Thr360Ala Single submitter
Uncertain significance 111
- p.Ala104Val Single submitter ⚠
- p.Ala114Val Single submitter ⚠
- p.Ala12Pro Single submitter ⚠
- p.Ala12Ser Single submitter ⚠
- p.Ala155Ser Single submitter ⚠
- p.Ala155Val Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala203Ser Single submitter ⚠
- p.Ala213Ser Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala376Gly Single submitter ⚠
- p.Ala527Val Single submitter ⚠
- p.Ala549Pro Single submitter ⚠
- p.Ala549Thr Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg116Leu Single submitter ⚠
- p.Arg116Pro Single submitter ⚠
- p.Arg164Pro Single submitter ⚠
- p.Arg254Lys Single submitter ⚠
- p.Arg254Met Single submitter ⚠
- p.Arg280Thr Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg357Cys Single submitter ⚠
- p.Arg412Gln Single submitter ⚠
- p.Arg431His Single submitter ⚠
- p.Arg437Gln Single submitter ⚠
- p.Arg524Gln Single submitter ⚠
- p.Arg524Trp Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg56Leu Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg628Gln Single submitter ⚠
- p.Arg628Trp Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Asp198Tyr Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Asp211Gly Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Asp393Tyr Single submitter
- p.Asp450Glu Single submitter ⚠
- p.Asp58Asn Single submitter ⚠
- p.Cys102Trp Single submitter ⚠
- p.Cys13Arg Single submitter ⚠
- p.Cys13Tyr Single submitter ⚠
- p.Gln142Arg Single submitter ⚠
- p.Gln179Arg Single submitter ⚠
- p.Gln181Leu Single submitter ⚠
- p.Gln631Leu Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Glu504Ala Single submitter ⚠
- p.Glu619Lys Single submitter ⚠
- p.Glu621Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly171Asp Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly343Val Single submitter
- p.Gly369Arg Single submitter ⚠
- p.Gly384Arg Single submitter ⚠
- p.Gly387Asp Single submitter ⚠
- p.Gly88Asp Single submitter ⚠
- p.Gly97Ser Single submitter ⚠
- p.Gly99Ser Single submitter ⚠
- p.Ile120Leu Single submitter ⚠
- p.Ile341Met Single submitter ⚠
- p.Ile383Thr Single submitter ⚠
- p.Ile435Leu Single submitter ⚠
- p.Ile477Val Single submitter ⚠
- p.Ile486Val Single submitter ⚠
- p.Leu208Trp Single submitter ⚠
- p.Leu615Val Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys54Gln Single submitter ⚠
- p.Lys95Arg Single submitter ⚠
- p.Lys95Glu Single submitter ⚠
- p.Met455Thr Single submitter ⚠
- p.Phe166Leu Single submitter ⚠
- p.Phe422Leu Single submitter ⚠
- p.Pro125Arg Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro31Gln Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro37His Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro44Arg Single submitter ⚠
- p.Pro507Leu Single submitter ⚠
- p.Pro51Thr Single submitter ⚠
- p.Pro52Arg Single submitter ⚠
- p.Pro52Ser Single submitter ⚠
- p.Pro55Arg Single submitter ⚠
- p.Ser15Gly Single submitter ⚠
- p.Ser168Thr Single submitter ⚠
- p.Ser176Leu Single submitter ⚠
- p.Ser262Phe Single submitter ⚠
- p.Ser492Leu Single submitter ⚠
- p.Ser67Phe Single submitter ⚠
- p.Thr272Ser Single submitter ⚠
- p.Thr294Ala Single submitter ⚠
- p.Thr501Asn Single submitter ⚠
- p.Tyr626Cys Single submitter ⚠
- p.Val217Met Single submitter ⚠
- p.Val339Ile Single submitter ⚠
- p.Val362Ile Single submitter ⚠
- p.Val475Ile Single submitter ⚠
- p.Val489Leu Single submitter ⚠
- p.Val489Met Single submitter ⚠
- p.Val543Ile Single submitter