CABLES2 — 102 ClinVar variants
All ClinVar germline CABLES2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
1 Benign · 3 Likely benign · 98 Uncertain significance
Full CABLES2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CABLES2 p.Arg128His Uncertain significance Multiple submitters
- CABLES2 p.Ala287Val Uncertain significance Single submitter
- CABLES2 p.Ala384Val Uncertain significance Single submitter
- CABLES2 p.Ala76Ser Uncertain significance Single submitter
- CABLES2 p.Ala9Ser Uncertain significance Single submitter
- CABLES2 p.Arg184Trp Uncertain significance Single submitter
- CABLES2 p.Arg278Lys Uncertain significance Single submitter
- CABLES2 p.Arg37Gly Uncertain significance Single submitter
- CABLES2 p.Arg404Cys Uncertain significance Single submitter
- CABLES2 p.Arg439Pro Uncertain significance Single submitter
- CABLES2 p.Asp136Glu Uncertain significance Single submitter
- CABLES2 p.Gln101His Uncertain significance Single submitter
- CABLES2 p.Gln108Arg Uncertain significance Single submitter
- CABLES2 p.Gln127His Uncertain significance Single submitter
- CABLES2 p.Gln211Glu Uncertain significance Single submitter
- CABLES2 p.Glu88Lys Uncertain significance Single submitter
- CABLES2 p.Gly316Ser Uncertain significance Single submitter
- CABLES2 p.Gly426Ala Uncertain significance Single submitter
- CABLES2 p.Gly65Ser Uncertain significance Single submitter
- CABLES2 p.Gly7Ser Uncertain significance Single submitter
- CABLES2 p.Gly8Arg Uncertain significance Single submitter
- CABLES2 p.Leu301Pro Uncertain significance Single submitter
- CABLES2 p.Leu460Pro Uncertain significance Single submitter
- CABLES2 p.Leu474Pro Uncertain significance Single submitter
- CABLES2 p.Leu93Val Uncertain significance Single submitter
- CABLES2 p.Lys342Asn Uncertain significance Single submitter
- CABLES2 p.Met167Leu Uncertain significance Single submitter
- CABLES2 p.Met369Thr Uncertain significance Single submitter
- CABLES2 p.Phe352Leu Uncertain significance Single submitter
- CABLES2 p.Phe448Ser Uncertain significance Single submitter
- CABLES2 p.Pro10Ala Uncertain significance Single submitter
- CABLES2 p.Pro19Ala Uncertain significance Single submitter
- CABLES2 p.Pro214Leu Uncertain significance Single submitter
- CABLES2 p.Pro283Leu Uncertain significance Single submitter
- CABLES2 p.Pro311Leu Uncertain significance Single submitter
- CABLES2 p.Pro90Ser Uncertain significance Single submitter
- CABLES2 p.Thr161Ile Uncertain significance Single submitter
- CABLES2 p.Thr265Ile Uncertain significance Single submitter
- CABLES2 p.Thr291Lys Uncertain significance Single submitter
- CABLES2 p.Thr382Met Uncertain significance Single submitter
- CABLES2 p.Tyr327Cys Uncertain significance Single submitter
- CABLES2 p.Val240Met Uncertain significance Single submitter
- CABLES2 p.Val321Ala Uncertain significance Single submitter
- CABLES2 p.Val412Gly Uncertain significance Single submitter
- CABLES2 p.Val452Ala Uncertain significance Single submitter
Predictors split 55
The independent predictors disagree with each other — read with care.
- CABLES2 p.Ala13Asp Uncertain significance Single submitter
- CABLES2 p.Ala17Thr Uncertain significance Single submitter
- CABLES2 p.Ala23Asp Uncertain significance Single submitter
- CABLES2 p.Ala23Thr Uncertain significance Single submitter
- CABLES2 p.Ala35Val Uncertain significance Single submitter
- CABLES2 p.Ala410Thr Uncertain significance Single submitter
- CABLES2 p.Ala4Val Uncertain significance Single submitter
- CABLES2 p.Ala9Thr Uncertain significance Single submitter
- CABLES2 p.Ala9Val Uncertain significance Single submitter
- CABLES2 p.Arg123Gln Uncertain significance Single submitter
- CABLES2 p.Arg200Trp Uncertain significance Single submitter
- CABLES2 p.Arg272Trp Uncertain significance Single submitter
- CABLES2 p.Arg320His Uncertain significance Single submitter
- CABLES2 p.Arg370Gln Uncertain significance Single submitter
- CABLES2 p.Arg370Trp Uncertain significance Single submitter
- CABLES2 p.Arg442Lys Uncertain significance Single submitter
- CABLES2 p.Arg44Leu Uncertain significance Single submitter
- CABLES2 p.Arg45Leu Uncertain significance Single submitter
- CABLES2 p.Asp299His Uncertain significance Single submitter
- CABLES2 p.Asp41Glu Uncertain significance Single submitter
- CABLES2 p.Asp444Asn Uncertain significance Single submitter
- CABLES2 p.Cys187Arg Uncertain significance Single submitter
- CABLES2 p.Gln169His Uncertain significance Single submitter
- CABLES2 p.Glu346Lys Uncertain significance Single submitter
- CABLES2 p.Gly426Ser Uncertain significance Single submitter
- CABLES2 p.His279Tyr Likely benign Single submitter
- CABLES2 p.Ile55Val Uncertain significance Single submitter
- CABLES2 p.Lys356Gln Uncertain significance Single submitter
- CABLES2 p.Phe51Val Uncertain significance Single submitter
- CABLES2 p.Pro10Arg Uncertain significance Single submitter
- CABLES2 p.Pro10Gln Uncertain significance Single submitter
- CABLES2 p.Pro10Leu Uncertain significance Single submitter
- CABLES2 p.Pro10Thr Uncertain significance Single submitter
- CABLES2 p.Pro12Arg Uncertain significance Single submitter
- CABLES2 p.Pro12Gln Uncertain significance Single submitter
- CABLES2 p.Pro12Leu Uncertain significance Single submitter
- CABLES2 p.Pro12Ser Uncertain significance Single submitter
- CABLES2 p.Pro14Thr Uncertain significance Single submitter
- CABLES2 p.Pro20Ser Uncertain significance Single submitter
- CABLES2 p.Pro21Thr Uncertain significance Single submitter
- CABLES2 p.Pro380His Uncertain significance Single submitter
- CABLES2 p.Pro66Arg Uncertain significance Single submitter
- CABLES2 p.Pro71Leu Uncertain significance Single submitter
- CABLES2 p.Pro71Thr Uncertain significance Single submitter
- CABLES2 p.Pro72Ser Uncertain significance Single submitter
- CABLES2 p.Pro74Leu Uncertain significance Single submitter
- CABLES2 p.Ser290Arg Uncertain significance Single submitter
- CABLES2 p.Ser290Asn Uncertain significance Single submitter
- CABLES2 p.Thr347Asn Uncertain significance Single submitter
- CABLES2 p.Thr97Ile Uncertain significance Single submitter
- CABLES2 p.Val178Met Uncertain significance Single submitter
- CABLES2 p.Val331Met Uncertain significance Single submitter
- CABLES2 p.Val335Met Uncertain significance Single submitter
- CABLES2 p.Val427Met Uncertain significance Single submitter
-
CABLES2 p.Val220Met
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All CABLES2 variants
Benign 1
- p.Leu103= Multiple submitters
Likely benign 3
- p.His279Tyr Single submitter ⚠
- p.Thr91Ala Single submitter
- p.Val220Met No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 98
- p.Arg128His Multiple submitters ⚠
- p.Ala13Asp Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala23Asp Single submitter ⚠
- p.Ala23Thr Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala384Val Single submitter ⚠
- p.Ala410Thr Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala76Ser Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg272Trp Single submitter ⚠
- p.Arg278Lys Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg37Gly Single submitter ⚠
- p.Arg404Cys Single submitter ⚠
- p.Arg439Pro Single submitter ⚠
- p.Arg442Lys Single submitter ⚠
- p.Arg44Leu Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Asp136Glu Single submitter ⚠
- p.Asp299His Single submitter ⚠
- p.Asp41Glu Single submitter ⚠
- p.Asp444Asn Single submitter ⚠
- p.Cys187Arg Single submitter ⚠
- p.Gln101His Single submitter ⚠
- p.Gln108Arg Single submitter ⚠
- p.Gln127His Single submitter ⚠
- p.Gln169His Single submitter ⚠
- p.Gln211Glu Single submitter ⚠
- p.Glu346Lys Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.Gly426Ala Single submitter ⚠
- p.Gly426Ser Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.Gly7Ser Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Leu301Pro Single submitter ⚠
- p.Leu460Pro Single submitter ⚠
- p.Leu474Pro Single submitter ⚠
- p.Leu93Val Single submitter ⚠
- p.Lys342Asn Single submitter ⚠
- p.Lys356Gln Single submitter ⚠
- p.Met167Leu Single submitter ⚠
- p.Met369Thr Single submitter ⚠
- p.Phe352Leu Single submitter ⚠
- p.Phe448Ser Single submitter ⚠
- p.Phe51Val Single submitter ⚠
- p.Pro10Ala Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro10Gln Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro10Thr Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro12Gln Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro14Thr Single submitter ⚠
- p.Pro19Ala Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro21Thr Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro311Leu Single submitter ⚠
- p.Pro380His Single submitter ⚠
- p.Pro66Arg Single submitter ⚠
- p.Pro71Leu Single submitter ⚠
- p.Pro71Thr Single submitter ⚠
- p.Pro72Ser Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Ser290Arg Single submitter ⚠
- p.Ser290Asn Single submitter ⚠
- p.Thr161Ile Single submitter ⚠
- p.Thr265Ile Single submitter ⚠
- p.Thr291Lys Single submitter ⚠
- p.Thr347Asn Single submitter ⚠
- p.Thr382Met Single submitter ⚠
- p.Thr97Ile Single submitter ⚠
- p.Tyr327Cys Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val321Ala Single submitter ⚠
- p.Val331Met Single submitter ⚠
- p.Val335Met Single submitter ⚠
- p.Val412Gly Single submitter ⚠
- p.Val427Met Single submitter ⚠
- p.Val452Ala Single submitter ⚠