CABS1 — 57 ClinVar variants
All ClinVar germline CABS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Benign · 5 Likely benign · 51 Uncertain significance
Full CABS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CABS1 p.Ala204Ser Uncertain significance Single submitter
- CABS1 p.Ala295Asp Uncertain significance Single submitter
- CABS1 p.Ala327Glu Uncertain significance Single submitter
- CABS1 p.Ala330Thr Uncertain significance Single submitter
- CABS1 p.Arg181Gly Uncertain significance Single submitter
- CABS1 p.Asn348Asp Uncertain significance Single submitter
- CABS1 p.Asp288Gly Uncertain significance Single submitter
- CABS1 p.Asp342Tyr Uncertain significance Single submitter
- CABS1 p.Glu113Lys Uncertain significance Single submitter
- CABS1 p.Glu142Lys Uncertain significance Single submitter
- CABS1 p.Glu203Lys Uncertain significance Single submitter
- CABS1 p.Glu388Asp Uncertain significance Single submitter
- CABS1 p.Gly172Arg Uncertain significance Single submitter
- CABS1 p.His310Tyr Uncertain significance Single submitter
- CABS1 p.Ile106Leu Uncertain significance Single submitter
- CABS1 p.Ile144Thr Uncertain significance Single submitter
- CABS1 p.Leu132Val Uncertain significance Single submitter
- CABS1 p.Lys167Glu Uncertain significance Single submitter
- CABS1 p.Lys276Thr Uncertain significance Single submitter
- CABS1 p.Lys67Thr Uncertain significance Single submitter
- CABS1 p.Met116Thr Uncertain significance Single submitter
- CABS1 p.Met116Val Uncertain significance Single submitter
- CABS1 p.Pro126Ser Uncertain significance Single submitter
- CABS1 p.Pro353His Uncertain significance Single submitter
- CABS1 p.Pro358Leu Uncertain significance Single submitter
- CABS1 p.Ser193Phe Uncertain significance Single submitter
- CABS1 p.Ser194Ala Uncertain significance Single submitter
- CABS1 p.Ser252Thr Uncertain significance Single submitter
- CABS1 p.Ser77Leu Uncertain significance Single submitter
- CABS1 p.Thr159Ile Uncertain significance Single submitter
- CABS1 p.Thr165Pro Uncertain significance Single submitter
- CABS1 p.Thr303Ala Uncertain significance Single submitter
- CABS1 p.Thr309Ile Uncertain significance Single submitter
- CABS1 p.Thr39Lys Uncertain significance Single submitter
- CABS1 p.Thr40Ser Uncertain significance Single submitter
- CABS1 p.Val207Ala Uncertain significance Single submitter
- CABS1 p.Val324Ile Uncertain significance Single submitter
- CABS1 p.Val365Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CABS1 p.Ala2Val Uncertain significance Single submitter
- CABS1 p.Asp370His Uncertain significance Single submitter
- CABS1 p.Asp374Gly Uncertain significance Single submitter
- CABS1 p.Glu388Gln Uncertain significance Single submitter
- CABS1 p.Gly5Asp Uncertain significance Single submitter
- CABS1 p.Gly5Val Uncertain significance Single submitter
- CABS1 p.Leu244Pro Uncertain significance Single submitter
- CABS1 p.Leu99Arg Uncertain significance Single submitter
- CABS1 p.Lys76Arg Likely benign Single submitter
- CABS1 p.Pro326His Uncertain significance Single submitter
- CABS1 p.Thr148Ile Uncertain significance Single submitter
- CABS1 p.Thr22Ile Uncertain significance Single submitter
- CABS1 p.Thr25Ile Uncertain significance Single submitter
- CABS1 p.Thr272Asn Uncertain significance Single submitter
All CABS1 variants
Benign 1
- p.Thr15Ala Multiple submitters
Likely benign 5
- p.Arg281Gln Single submitter
- p.Asp381Gly Single submitter
- p.Ile297Val Single submitter
- p.Lys76Arg Single submitter ⚠
- p.Thr351Ser Single submitter
Uncertain significance 51
- p.Ala204Ser Single submitter ⚠
- p.Ala295Asp Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala327Glu Single submitter ⚠
- p.Ala330Thr Single submitter ⚠
- p.Arg181Gly Single submitter ⚠
- p.Asn348Asp Single submitter ⚠
- p.Asp288Gly Single submitter ⚠
- p.Asp342Tyr Single submitter ⚠
- p.Asp370His Single submitter ⚠
- p.Asp374Gly Single submitter ⚠
- p.Glu113Lys Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu388Asp Single submitter ⚠
- p.Glu388Gln Single submitter ⚠
- p.Gly172Arg Single submitter ⚠
- p.Gly5Asp Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.His310Tyr Single submitter ⚠
- p.Ile106Leu Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Leu132Val Single submitter ⚠
- p.Leu244Pro Single submitter ⚠
- p.Leu99Arg Single submitter ⚠
- p.Lys167Glu Single submitter ⚠
- p.Lys276Thr Single submitter ⚠
- p.Lys67Thr Single submitter ⚠
- p.Met116Thr Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Pro126Ser Single submitter ⚠
- p.Pro326His Single submitter ⚠
- p.Pro353His Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Ser193Phe Single submitter ⚠
- p.Ser194Ala Single submitter ⚠
- p.Ser252Thr Single submitter ⚠
- p.Ser77Leu Single submitter ⚠
- p.Thr148Ile Single submitter ⚠
- p.Thr159Ile Single submitter ⚠
- p.Thr165Pro Single submitter ⚠
- p.Thr22Ile Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Thr272Asn Single submitter ⚠
- p.Thr303Ala Single submitter ⚠
- p.Thr309Ile Single submitter ⚠
- p.Thr39Lys Single submitter ⚠
- p.Thr40Ser Single submitter ⚠
- p.Val207Ala Single submitter ⚠
- p.Val324Ile Single submitter ⚠
- p.Val365Leu Single submitter ⚠