CACNG3 — 19 ClinVar variants
All ClinVar germline CACNG3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
19 Uncertain significance
Full CACNG3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CACNG3 p.Ala161Thr Uncertain significance Single submitter
- CACNG3 p.Ala27Gly Uncertain significance Single submitter
- CACNG3 p.Ala287Thr Uncertain significance Single submitter
- CACNG3 p.Arg269Gln Uncertain significance Single submitter
- CACNG3 p.Arg284Trp Uncertain significance Single submitter
- CACNG3 p.Arg74Gln Uncertain significance Single submitter
- CACNG3 p.Asn133Ser Uncertain significance Single submitter
- CACNG3 p.Asp168Asn Uncertain significance Single submitter
- CACNG3 p.Asp270Asn Uncertain significance Single submitter
- CACNG3 p.Asp47Gly Uncertain significance Single submitter
- CACNG3 p.Cys121Ser Uncertain significance Single submitter
- CACNG3 p.Gln206Glu Uncertain significance Single submitter
- CACNG3 p.His204Tyr Uncertain significance Single submitter
- CACNG3 p.Met3Ile Uncertain significance Single submitter
- CACNG3 p.Pro271Ala Uncertain significance Single submitter
- CACNG3 p.Thr278Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CACNG3 variants
Uncertain significance 19
- c.295+1G>T Single submitter
- p.Ala161Thr Single submitter ⚠
- p.Ala27Gly Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asp168Asn Single submitter ⚠
- p.Asp270Asn Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Cys121Ser Single submitter ⚠
- p.Gln206Glu Single submitter ⚠
- p.His204Tyr Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Met3Ile Single submitter ⚠
- p.Pro271Ala Single submitter ⚠
- p.Ser237Phe Single submitter ⚠
- p.Thr278Ala Single submitter ⚠