CACNG4 — 41 ClinVar variants
All ClinVar germline CACNG4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
41 Uncertain significance
Full CACNG4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CACNG4 p.Ala195Thr Uncertain significance Single submitter
- CACNG4 p.Ala224Val Uncertain significance Single submitter
- CACNG4 p.Ala268Asp Uncertain significance Single submitter
- CACNG4 p.Arg3Gln Uncertain significance Single submitter
- CACNG4 p.Arg58Gly Uncertain significance Single submitter
- CACNG4 p.Asn90Ser Uncertain significance Single submitter
- CACNG4 p.Asp174Glu Uncertain significance Single submitter
- CACNG4 p.Asp49Glu Uncertain significance Single submitter
- CACNG4 p.Asp93Asn Uncertain significance Single submitter
- CACNG4 p.Glu173Lys Uncertain significance Single submitter
- CACNG4 p.Glu297Gly Uncertain significance Single submitter
- CACNG4 p.Gly126Ala Uncertain significance Single submitter
- CACNG4 p.Gly142Ser Uncertain significance Single submitter
- CACNG4 p.Gly7Arg Uncertain significance Single submitter
- CACNG4 p.Ile207Thr Uncertain significance Single submitter
- CACNG4 p.Ile26Val Uncertain significance Single submitter
- CACNG4 p.Lys176Asn Uncertain significance Single submitter
- CACNG4 p.Met276Thr Uncertain significance Single submitter
- CACNG4 p.Met319Arg Uncertain significance Single submitter
- CACNG4 p.Met48Val Uncertain significance Single submitter
- CACNG4 p.Phe221Ile Uncertain significance Single submitter
- CACNG4 p.Pro167Leu Uncertain significance Single submitter
- CACNG4 p.Pro53Ala Uncertain significance Single submitter
- CACNG4 p.Ser227Pro Uncertain significance Single submitter
- CACNG4 p.Thr197Ile Uncertain significance Single submitter
- CACNG4 p.Tyr159Ser Uncertain significance Single submitter
- CACNG4 p.Val104Leu Uncertain significance Single submitter
- CACNG4 p.Val194Leu Uncertain significance Single submitter
- CACNG4 p.Val258Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CACNG4 p.Arg133His Uncertain significance Single submitter
- CACNG4 p.Arg219Trp Uncertain significance Single submitter
- CACNG4 p.Arg322Gln Uncertain significance Single submitter
- CACNG4 p.Arg323Gln Uncertain significance Single submitter
- CACNG4 p.Arg82Gln Uncertain significance Single submitter
- CACNG4 p.Arg82Trp Uncertain significance Single submitter
- CACNG4 p.Asn136His Uncertain significance Single submitter
- CACNG4 p.Asn84Ser Uncertain significance Single submitter
- CACNG4 p.Ile154Val Uncertain significance Single submitter
- CACNG4 p.Leu279Pro Uncertain significance Single submitter
- CACNG4 p.Tyr238Cys Uncertain significance Single submitter
- CACNG4 p.Val258Met Uncertain significance Single submitter
All CACNG4 variants
Uncertain significance 41
- p.Ala195Thr Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Ala268Asp Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg3Gln Single submitter ⚠
- p.Arg58Gly Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Asn136His Single submitter ⚠
- p.Asn84Ser Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp174Glu Single submitter ⚠
- p.Asp49Glu Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu297Gly Single submitter ⚠
- p.Gly126Ala Single submitter ⚠
- p.Gly142Ser Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.Ile154Val Single submitter ⚠
- p.Ile207Thr Single submitter ⚠
- p.Ile26Val Single submitter ⚠
- p.Leu279Pro Single submitter ⚠
- p.Lys176Asn Single submitter ⚠
- p.Met276Thr Single submitter ⚠
- p.Met319Arg Single submitter ⚠
- p.Met48Val Single submitter ⚠
- p.Phe221Ile Single submitter ⚠
- p.Pro167Leu Single submitter ⚠
- p.Pro53Ala Single submitter ⚠
- p.Ser227Pro Single submitter ⚠
- p.Thr197Ile Single submitter ⚠
- p.Tyr159Ser Single submitter ⚠
- p.Tyr238Cys Single submitter ⚠
- p.Val104Leu Single submitter ⚠
- p.Val194Leu Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val258Met Single submitter ⚠