CACNG5 — 51 ClinVar variants
All ClinVar germline CACNG5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 50 Uncertain significance
Full CACNG5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CACNG5 p.Ala167Thr Uncertain significance Single submitter
- CACNG5 p.Ala206Glu Uncertain significance Single submitter
- CACNG5 p.Ala250Ser Uncertain significance Single submitter
- CACNG5 p.Ala260Pro Uncertain significance Single submitter
- CACNG5 p.Ala65Thr Uncertain significance Single submitter
- CACNG5 p.Arg218His Uncertain significance Single submitter
- CACNG5 p.Arg60Gln Uncertain significance Single submitter
- CACNG5 p.Arg69Gln Uncertain significance Single submitter
- CACNG5 p.Arg98Cys Uncertain significance Single submitter
- CACNG5 p.Asp226Asn Uncertain significance Single submitter
- CACNG5 p.Asp266Gly Uncertain significance Single submitter
- CACNG5 p.Asp31Asn Uncertain significance Single submitter
- CACNG5 p.Gly121Arg Uncertain significance Single submitter
- CACNG5 p.Gly193Arg Uncertain significance Single submitter
- CACNG5 p.Ile113Val Uncertain significance Single submitter
- CACNG5 p.Ile153Asn Uncertain significance Single submitter
- CACNG5 p.Leu64Pro Uncertain significance Single submitter
- CACNG5 p.Met270Ile Uncertain significance Single submitter
- CACNG5 p.Met270Val Uncertain significance Single submitter
- CACNG5 p.Met52Leu Uncertain significance Single submitter
- CACNG5 p.Met52Thr Uncertain significance Single submitter
- CACNG5 p.Phe186Cys Uncertain significance Single submitter
- CACNG5 p.Pro212Ser Uncertain significance Single submitter
- CACNG5 p.Ser178Leu Uncertain significance Single submitter
- CACNG5 p.Ser251Cys Uncertain significance Single submitter
- CACNG5 p.Ser271Phe Uncertain significance Single submitter
- CACNG5 p.Thr48Ile Uncertain significance Single submitter
- CACNG5 p.Tyr217Cys Uncertain significance Single submitter
- CACNG5 p.Tyr217Ser Uncertain significance Single submitter
- CACNG5 p.Val40Met Uncertain significance Single submitter
- CACNG5 p.Val93Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CACNG5 p.Arg124Cys Uncertain significance Single submitter
- CACNG5 p.Arg124His Uncertain significance Single submitter
- CACNG5 p.Arg220Gln Uncertain significance Single submitter
- CACNG5 p.Arg220Trp Uncertain significance Single submitter
- CACNG5 p.Arg69Pro Uncertain significance Single submitter
- CACNG5 p.Arg69Trp Uncertain significance Single submitter
- CACNG5 p.Asp158Glu Uncertain significance Single submitter
- CACNG5 p.His55Asn Uncertain significance Single submitter
- CACNG5 p.Leu34Met Uncertain significance Single submitter
- CACNG5 p.Lys7Asn Uncertain significance Single submitter
- CACNG5 p.Met201Ile Uncertain significance Single submitter
- CACNG5 p.Met96Val Uncertain significance Single submitter
- CACNG5 p.Phe231Cys Uncertain significance Single submitter
- CACNG5 p.Phe63Val Uncertain significance Single submitter
- CACNG5 p.Thr128Met Uncertain significance Single submitter
- CACNG5 p.Val146Met Uncertain significance Single submitter
- CACNG5 p.Val61Phe Uncertain significance Single submitter
All CACNG5 variants
Benign 1
- p.Cys19= Single submitter
Uncertain significance 50
- p.Ala167Thr Single submitter ⚠
- p.Ala206Glu Single submitter ⚠
- p.Ala250Ser Single submitter ⚠
- p.Ala260Pro Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg69Pro Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Asp158Glu Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Asp266Gly Single submitter ⚠
- p.Asp31Asn Single submitter ⚠
- p.Gly121Arg Single submitter ⚠
- p.Gly193Arg Single submitter ⚠
- p.His55Asn Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile153Asn Single submitter ⚠
- p.Leu140Val Single submitter
- p.Leu34Met Single submitter ⚠
- p.Leu64Pro Single submitter ⚠
- p.Lys7Asn Single submitter ⚠
- p.Met201Ile Single submitter ⚠
- p.Met270Ile Single submitter ⚠
- p.Met270Val Single submitter ⚠
- p.Met52Leu Single submitter ⚠
- p.Met52Thr Single submitter ⚠
- p.Met96Val Single submitter ⚠
- p.Phe186Cys Single submitter ⚠
- p.Phe231Cys Single submitter ⚠
- p.Phe63Val Single submitter ⚠
- p.Pro212Ser Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Ser251Cys Single submitter ⚠
- p.Ser271Phe Single submitter ⚠
- p.Thr128Met Single submitter ⚠
- p.Thr48Ile Single submitter ⚠
- p.Thr90Met Single submitter
- p.Tyr217Cys Single submitter ⚠
- p.Tyr217Ser Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val61Phe Single submitter ⚠
- p.Val93Ile Single submitter ⚠