CACNG6 — 59 ClinVar variants
All ClinVar germline CACNG6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
1 Likely benign · 58 Uncertain significance
Full CACNG6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CACNG6 p.Ala198Val Uncertain significance Single submitter
- CACNG6 p.Ala259Thr Uncertain significance Single submitter
- CACNG6 p.Ala50Gly Uncertain significance Single submitter
- CACNG6 p.Ala94Thr Uncertain significance Single submitter
- CACNG6 p.Arg193Leu Uncertain significance Single submitter
- CACNG6 p.Arg90Leu Uncertain significance Single submitter
- CACNG6 p.Asp101Asn Uncertain significance Single submitter
- CACNG6 p.Cys158Arg Uncertain significance Single submitter
- CACNG6 p.Cys158Tyr Uncertain significance Single submitter
- CACNG6 p.Cys177Ser Uncertain significance Single submitter
- CACNG6 p.Cys237Ser Uncertain significance Single submitter
- CACNG6 p.Cys237Tyr Uncertain significance Single submitter
- CACNG6 p.Cys76Tyr Uncertain significance Single submitter
- CACNG6 p.Glu216Lys Uncertain significance Single submitter
- CACNG6 p.Glu36Lys Uncertain significance Single submitter
- CACNG6 p.Glu60Asp Uncertain significance Single submitter
- CACNG6 p.Gly25Arg Uncertain significance Single submitter
- CACNG6 p.Gly82Arg Uncertain significance Single submitter
- CACNG6 p.Leu149Val Uncertain significance Single submitter
- CACNG6 p.Leu163Val Uncertain significance Single submitter
- CACNG6 p.Leu184Gln Uncertain significance Single submitter
- CACNG6 p.Leu185Val Uncertain significance Single submitter
- CACNG6 p.Lys134Glu Uncertain significance Single submitter
- CACNG6 p.Met2Leu Uncertain significance Single submitter
- CACNG6 p.Pro208Thr Uncertain significance Single submitter
- CACNG6 p.Ser204Thr Uncertain significance Single submitter
- CACNG6 p.Thr122Met Uncertain significance Single submitter
- CACNG6 p.Thr260Asn Uncertain significance Single submitter
- CACNG6 p.Thr88Ala Uncertain significance Single submitter
- CACNG6 p.Thr88Ile Uncertain significance Single submitter
- CACNG6 p.Val173Ala Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CACNG6 p.Ala142Val Uncertain significance Single submitter
- CACNG6 p.Ala17Val Uncertain significance Single submitter
- CACNG6 p.Ala18Val Uncertain significance Single submitter
- CACNG6 p.Ala227Thr Uncertain significance Single submitter
- CACNG6 p.Ala47Thr Uncertain significance Single submitter
- CACNG6 p.Arg13Gln Uncertain significance Single submitter
- CACNG6 p.Arg202Ile Uncertain significance Single submitter
- CACNG6 p.Arg22Leu Uncertain significance Single submitter
- CACNG6 p.Arg90Trp Uncertain significance Single submitter
- CACNG6 p.Asn113Asp Uncertain significance Single submitter
- CACNG6 p.Gln9His Uncertain significance Single submitter
- CACNG6 p.Glu64Lys Uncertain significance Single submitter
- CACNG6 p.Glu77Lys Uncertain significance Single submitter
- CACNG6 p.Gly236Ser Uncertain significance Single submitter
- CACNG6 p.Leu157Phe Uncertain significance Single submitter
- CACNG6 p.Leu240Gln Uncertain significance Single submitter
- CACNG6 p.Leu243Arg Uncertain significance Single submitter
- CACNG6 p.Lys69Glu Uncertain significance Single submitter
- CACNG6 p.Met2Thr Uncertain significance Single submitter
- CACNG6 p.Phe6Ser Uncertain significance Single submitter
- CACNG6 p.Pro105Leu Uncertain significance Single submitter
- CACNG6 p.Pro105Ser Uncertain significance Single submitter
- CACNG6 p.Pro209Leu Uncertain significance Single submitter
- CACNG6 p.Thr242Ile Uncertain significance Single submitter
- CACNG6 p.Trp3Ser Uncertain significance Single submitter
- CACNG6 p.Tyr116Cys Uncertain significance Single submitter
- CACNG6 p.Val57Ala Uncertain significance Single submitter
All CACNG6 variants
Likely benign 1
- p.Arg127His Single submitter
Uncertain significance 58
- p.Ala142Val Single submitter ⚠
- p.Ala17Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala198Val Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Ala50Gly Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg193Leu Single submitter ⚠
- p.Arg202Ile Single submitter ⚠
- p.Arg22Leu Single submitter ⚠
- p.Arg90Leu Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asp101Asn Single submitter ⚠
- p.Cys158Arg Single submitter ⚠
- p.Cys158Tyr Single submitter ⚠
- p.Cys177Ser Single submitter ⚠
- p.Cys237Ser Single submitter ⚠
- p.Cys237Tyr Single submitter ⚠
- p.Cys76Tyr Single submitter ⚠
- p.Gln9His Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Glu60Asp Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Gly236Ser Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly82Arg Single submitter ⚠
- p.Leu149Val Single submitter ⚠
- p.Leu157Phe Single submitter ⚠
- p.Leu163Val Single submitter ⚠
- p.Leu184Gln Single submitter ⚠
- p.Leu185Val Single submitter ⚠
- p.Leu240Gln Single submitter ⚠
- p.Leu243Arg Single submitter ⚠
- p.Lys134Glu Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met2Leu Single submitter ⚠
- p.Met2Thr Single submitter ⚠
- p.Phe6Ser Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Pro105Ser Single submitter ⚠
- p.Pro208Thr Single submitter ⚠
- p.Pro209Leu Single submitter ⚠
- p.Ser204Thr Single submitter ⚠
- p.Thr122Met Single submitter ⚠
- p.Thr242Ile Single submitter ⚠
- p.Thr260Asn Single submitter ⚠
- p.Thr88Ala Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Trp3Ser Single submitter ⚠
- p.Tyr116Cys Single submitter ⚠
- p.Val173Ala Single submitter ⚠
- p.Val57Ala Single submitter ⚠