CACNG8 — 67 ClinVar variants
All ClinVar germline CACNG8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Likely benign · 66 Uncertain significance
Full CACNG8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CACNG8 p.Ala183Ser Uncertain significance Single submitter
- CACNG8 p.Ala289Ser Uncertain significance Single submitter
- CACNG8 p.Ala362Ser Uncertain significance Single submitter
- CACNG8 p.Ala407Val Uncertain significance Single submitter
- CACNG8 p.Ala410Ser Uncertain significance Single submitter
- CACNG8 p.Ala73Pro Uncertain significance Single submitter
- CACNG8 p.Arg150Cys Uncertain significance Single submitter
- CACNG8 p.Asn8Lys Uncertain significance Single submitter
- CACNG8 p.Cys236Gly Uncertain significance Single submitter
- CACNG8 p.Glu187Lys Uncertain significance Single submitter
- CACNG8 p.Glu409Asp Uncertain significance Single submitter
- CACNG8 p.Gly186Asp Uncertain significance Single submitter
- CACNG8 p.Gly18Glu Uncertain significance Single submitter
- CACNG8 p.Gly296Ala Uncertain significance Single submitter
- CACNG8 p.Gly298Ala Uncertain significance Single submitter
- CACNG8 p.Gly360Ala Uncertain significance Single submitter
- CACNG8 p.Gly60Asp Uncertain significance Single submitter
- CACNG8 p.Gly72Ser Uncertain significance Single submitter
- CACNG8 p.Ile228Phe Uncertain significance Single submitter
- CACNG8 p.Leu243Val Uncertain significance Single submitter
- CACNG8 p.Leu366Ile Uncertain significance Single submitter
- CACNG8 p.Leu366Val Uncertain significance Single submitter
- CACNG8 p.Met35Val Uncertain significance Single submitter
- CACNG8 p.Pro391Ala Uncertain significance Single submitter
- CACNG8 p.Pro79Thr Uncertain significance Single submitter
- CACNG8 p.Ser252Thr Uncertain significance Single submitter
- CACNG8 p.Ser258Leu Uncertain significance Single submitter
- CACNG8 p.Thr405Pro Uncertain significance Single submitter
- CACNG8 p.Thr55Ser Uncertain significance Single submitter
- CACNG8 p.Val124Ala Uncertain significance Single submitter
- CACNG8 p.Val146Leu Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CACNG8 p.Ala323Val Uncertain significance Single submitter
- CACNG8 p.Ala325Thr Uncertain significance Single submitter
- CACNG8 p.Ala389Thr Uncertain significance Single submitter
- CACNG8 p.Ala392Thr Uncertain significance Single submitter
- CACNG8 p.Ala400Val Uncertain significance Single submitter
- CACNG8 p.Arg359His Uncertain significance Single submitter
- CACNG8 p.Asn105Ser Uncertain significance Single submitter
- CACNG8 p.Glu194Gly Uncertain significance Single submitter
- CACNG8 p.Glu233Lys Uncertain significance Single submitter
- CACNG8 p.Glu409Lys Uncertain significance Single submitter
- CACNG8 p.Gly246Ser Uncertain significance Single submitter
- CACNG8 p.Gly248Asp Uncertain significance Single submitter
- CACNG8 p.Gly292Cys Uncertain significance Single submitter
- CACNG8 p.Gly296Asp Uncertain significance Single submitter
- CACNG8 p.Gly342Asp Uncertain significance Single submitter
- CACNG8 p.Gly345Asp Uncertain significance Single submitter
- CACNG8 p.Gly346Val Uncertain significance Single submitter
- CACNG8 p.Gly350Arg Uncertain significance Single submitter
- CACNG8 p.Gly352Glu Uncertain significance Single submitter
- CACNG8 p.Gly386Arg Uncertain significance Single submitter
- CACNG8 p.Gly70Cys Uncertain significance Single submitter
- CACNG8 p.Leu418Ile Uncertain significance Single submitter
- CACNG8 p.Pro283Arg Uncertain significance Single submitter
- CACNG8 p.Pro283Leu Uncertain significance Single submitter
- CACNG8 p.Pro387Gln Uncertain significance Single submitter
- CACNG8 p.Pro395Leu Uncertain significance Single submitter
- CACNG8 p.Pro396Leu Uncertain significance Single submitter
- CACNG8 p.Ser201Thr Uncertain significance Single submitter
- CACNG8 p.Ser314Phe Uncertain significance Single submitter
- CACNG8 p.Thr367Met Uncertain significance Single submitter
- CACNG8 p.Thr422Pro Uncertain significance Single submitter
- CACNG8 p.Tyr152Ser Uncertain significance Single submitter
- CACNG8 p.Val146Met Uncertain significance Single submitter
- CACNG8 p.Val380Ile Uncertain significance Single submitter
- CACNG8 p.Val382Ile Uncertain significance Single submitter
All CACNG8 variants
Likely benign 1
- p.Ala73Ser Single submitter
Uncertain significance 66
- p.Ala183Ser Single submitter ⚠
- p.Ala289Ser Single submitter ⚠
- p.Ala323Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala362Ser Single submitter ⚠
- p.Ala389Thr Single submitter ⚠
- p.Ala392Thr Single submitter ⚠
- p.Ala400Val Single submitter ⚠
- p.Ala407Val Single submitter ⚠
- p.Ala410Ser Single submitter ⚠
- p.Ala73Pro Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg359His Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asn8Lys Single submitter ⚠
- p.Cys236Gly Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu194Gly Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu409Asp Single submitter ⚠
- p.Glu409Lys Single submitter ⚠
- p.Gly186Asp Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly246Ser Single submitter ⚠
- p.Gly248Asp Single submitter ⚠
- p.Gly292Cys Single submitter ⚠
- p.Gly296Ala Single submitter ⚠
- p.Gly296Asp Single submitter ⚠
- p.Gly298Ala Single submitter ⚠
- p.Gly342Asp Single submitter ⚠
- p.Gly345Asp Single submitter ⚠
- p.Gly346Val Single submitter ⚠
- p.Gly350Arg Single submitter ⚠
- p.Gly352Glu Single submitter ⚠
- p.Gly360Ala Single submitter ⚠
- p.Gly386Arg Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.Gly70Cys Single submitter ⚠
- p.Gly72Ser Single submitter ⚠
- p.Ile228Phe Single submitter ⚠
- p.Leu243Val Single submitter ⚠
- p.Leu366Ile Single submitter ⚠
- p.Leu366Val Single submitter ⚠
- p.Leu418Ile Single submitter ⚠
- p.Met35Val Single submitter ⚠
- p.Pro283Arg Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro387Gln Single submitter ⚠
- p.Pro391Ala Single submitter ⚠
- p.Pro395Leu Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Pro79Thr Single submitter ⚠
- p.Ser201Thr Single submitter ⚠
- p.Ser252Thr Single submitter ⚠
- p.Ser258Leu Single submitter ⚠
- p.Ser314Phe Single submitter ⚠
- p.Thr367Met Single submitter ⚠
- p.Thr405Pro Single submitter ⚠
- p.Thr422Pro Single submitter ⚠
- p.Thr55Ser Single submitter ⚠
- p.Tyr152Ser Single submitter ⚠
- p.Val124Ala Single submitter ⚠
- p.Val146Leu Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val380Ile Single submitter ⚠
- p.Val382Ile Single submitter ⚠