CADM1 — 53 ClinVar variants
All ClinVar germline CADM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
8 Benign · 9 Likely benign · 36 Uncertain significance
Full CADM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CADM1 p.Ala156Val Uncertain significance Single submitter
- CADM1 p.Ala262Thr Uncertain significance Single submitter
- CADM1 p.Ala404Val Uncertain significance Single submitter
- CADM1 p.Arg258Trp Uncertain significance Single submitter
- CADM1 p.Arg399Gly Uncertain significance Single submitter
- CADM1 p.Asn46Ser Uncertain significance Single submitter
- CADM1 p.Asn80Ser Uncertain significance Single submitter
- CADM1 p.Asp70His Uncertain significance Single submitter
- CADM1 p.Asp71Asn Uncertain significance Single submitter
- CADM1 p.Glu439Lys Uncertain significance Single submitter
- CADM1 p.Gly393Ala Uncertain significance Single submitter
- CADM1 p.Ile116Leu Uncertain significance Single submitter
- CADM1 p.Leu355Pro Uncertain significance Single submitter
- CADM1 p.Leu38Val Uncertain significance Single submitter
- CADM1 p.Lys108Thr Uncertain significance Single submitter
- CADM1 p.Met206Leu Uncertain significance Single submitter
- CADM1 p.Ser34Ala Uncertain significance Single submitter
- CADM1 p.Thr41Arg Uncertain significance Single submitter
- CADM1 p.Val410Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CADM1 p.Ala291Thr Uncertain significance Single submitter
- CADM1 p.Arg145His Uncertain significance Single submitter
- CADM1 p.Gln232His Uncertain significance Single submitter
- CADM1 p.Gly182Arg Uncertain significance Single submitter
- CADM1 p.Ile177Leu Uncertain significance Single submitter
- CADM1 p.Ile247Val Uncertain significance Single submitter
- CADM1 p.Ile300Phe Uncertain significance Single submitter
- CADM1 p.Ile39Met Uncertain significance Single submitter
- CADM1 p.Ile471Leu Uncertain significance Single submitter
- CADM1 p.Leu26Pro Uncertain significance Single submitter
- CADM1 p.Leu32Phe Uncertain significance Single submitter
- CADM1 p.Leu420Phe Uncertain significance Single submitter
- CADM1 p.Thr279Ile Uncertain significance Single submitter
- CADM1 p.Thr351Ile Uncertain significance Single submitter
- CADM1 p.Val409Ile Uncertain significance Single submitter
- CADM1 p.Val4Glu Uncertain significance Single submitter
- CADM1 p.Thr41Ile Uncertain significance No assertion criteria
All CADM1 variants
Benign 8
- p.Ala226= Multiple submitters
- p.Ala262= Multiple submitters
- p.Asn301= Multiple submitters
- p.Asp307= Multiple submitters
- p.Thr351_Thr353del Multiple submitters
- c.563-4C>T Single submitter
- c.722-6A>C Single submitter
- p.Val4= Single submitter
Likely benign 9
- p.Thr336Ile Multiple submitters
- c.995-5T>C Single submitter
- p.Gly425= Single submitter
- p.Ile270= Single submitter
- p.Thr250= Single submitter
- p.Thr257= Single submitter
- p.Thr353del Single submitter
- p.Thr353dup Single submitter
- p.Val409= Single submitter
Uncertain significance 36
- p.Ala156Val Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala404Val Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg258Trp Single submitter ⚠
- p.Arg399Gly Single submitter ⚠
- p.Asn46Ser Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asp70His Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Gln232His Single submitter ⚠
- p.Glu439Lys Single submitter ⚠
- p.Gly182Arg Single submitter ⚠
- p.Gly393Ala Single submitter ⚠
- p.Ile116Leu Single submitter ⚠
- p.Ile177Leu Single submitter ⚠
- p.Ile247Val Single submitter ⚠
- p.Ile300Phe Single submitter ⚠
- p.Ile39Met Single submitter ⚠
- p.Ile471Leu Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Leu355Pro Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Leu420Phe Single submitter ⚠
- p.Lys108Thr Single submitter ⚠
- p.Met206Leu Single submitter ⚠
- p.Ser34Ala Single submitter ⚠
- p.Thr279Ile Single submitter ⚠
- p.Thr351Ile Single submitter ⚠
- p.Thr41Arg Single submitter ⚠
- p.Val409Ile Single submitter ⚠
- p.Val410Met Single submitter ⚠
- p.Val4Glu Single submitter ⚠
- p.Thr41Ile No assertion criteria ⚠