CADM2 — 38 ClinVar variants
All ClinVar germline CADM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
4 Benign · 34 Uncertain significance
Full CADM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CADM2 c.970+17585G>A Uncertain significance Single submitter
- CADM2 p.Ala69Ser Uncertain significance Single submitter
- CADM2 p.Arg90Cys Uncertain significance Single submitter
- CADM2 p.Cys257Gly Uncertain significance Single submitter
- CADM2 p.Gln248Lys Uncertain significance Single submitter
- CADM2 p.Glu266Gln Uncertain significance Single submitter
- CADM2 p.Glu276Lys Uncertain significance Single submitter
- CADM2 p.Glu306Asp Uncertain significance Single submitter
- CADM2 p.Glu87Lys Uncertain significance Single submitter
- CADM2 p.Gly358Arg Uncertain significance Single submitter
- CADM2 p.His233Tyr Uncertain significance Single submitter
- CADM2 p.Ile404Val Uncertain significance Single submitter
- CADM2 p.Leu115Ser Uncertain significance Single submitter
- CADM2 p.Lys173Arg Uncertain significance Single submitter
- CADM2 p.Met227Val Uncertain significance Single submitter
- CADM2 p.Pro267Leu Uncertain significance Single submitter
- CADM2 p.Pro325Ser Uncertain significance Single submitter
- CADM2 p.Pro68Leu Uncertain significance Single submitter
- CADM2 p.Thr235Lys Uncertain significance Single submitter
- CADM2 p.Thr308Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CADM2 c.970+17528A>T Uncertain significance Single submitter
- CADM2 c.970+17565C>A Uncertain significance Single submitter
- CADM2 c.970+17579A>G Uncertain significance Single submitter
- CADM2 p.Ala221Val Uncertain significance Single submitter
- CADM2 p.Ala316Val Uncertain significance Single submitter
- CADM2 p.Asn291Tyr Uncertain significance Single submitter
- CADM2 p.Gln228His Uncertain significance Single submitter
- CADM2 p.Glu398Gly Uncertain significance Single submitter
- CADM2 p.Gly275Arg Uncertain significance Single submitter
- CADM2 p.Ile138Phe Uncertain significance Single submitter
- CADM2 p.Leu51Phe Uncertain significance Single submitter
- CADM2 p.Ser142Leu Uncertain significance Single submitter
- CADM2 p.Val129Ile Uncertain significance Single submitter
- CADM2 p.Val43Ile Uncertain significance Single submitter
All CADM2 variants
Benign 4
- c.970+17639A>G Multiple submitters
- p.Cys155= Multiple submitters
- p.Ala327= Single submitter
- p.Thr350= Single submitter
Uncertain significance 34
- c.970+17528A>T Single submitter ⚠
- c.970+17565C>A Single submitter ⚠
- c.970+17579A>G Single submitter ⚠
- c.970+17585G>A Single submitter ⚠
- p.Ala221Val Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala69Ser Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Asn291Tyr Single submitter ⚠
- p.Cys257Gly Single submitter ⚠
- p.Gln228His Single submitter ⚠
- p.Gln248Lys Single submitter ⚠
- p.Glu266Gln Single submitter ⚠
- p.Glu276Lys Single submitter ⚠
- p.Glu306Asp Single submitter ⚠
- p.Glu398Gly Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly275Arg Single submitter ⚠
- p.Gly358Arg Single submitter ⚠
- p.His233Tyr Single submitter ⚠
- p.Ile138Phe Single submitter ⚠
- p.Ile404Val Single submitter ⚠
- p.Leu115Ser Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Lys173Arg Single submitter ⚠
- p.Met227Val Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro325Ser Single submitter ⚠
- p.Pro68Leu Single submitter ⚠
- p.Ser142Leu Single submitter ⚠
- p.Thr235Lys Single submitter ⚠
- p.Thr308Ala Single submitter ⚠
- p.Val129Ile Single submitter ⚠
- p.Val43Ile Single submitter ⚠