Sugi Variant

Sugi Variant/CADM3

CADM3 — 82 ClinVar variants

All ClinVar germline CADM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →

1 Likely pathogenic · 2 Conflicting · 1 Benign · 11 Likely benign · 67 Uncertain significance

Full CADM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 66

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 36

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 28

The independent predictors disagree with each other — read with care.

All CADM3 variants

Likely pathogenic 1

  • p.Tyr138Cys Multiple submitters Charcot-Marie-Tooth disease, axonal, type 2FF ⚠

Conflicting classifications of pathogenicity 2

Benign 1

Likely benign 11

Uncertain significance 67