CADM4 — 42 ClinVar variants
All ClinVar germline CADM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
42 Uncertain significance
Full CADM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CADM4 p.Ala324Pro Uncertain significance Single submitter
- CADM4 p.Arg45Gly Uncertain significance Single submitter
- CADM4 p.Arg6Ser Uncertain significance Single submitter
- CADM4 p.Arg95Cys Uncertain significance Single submitter
- CADM4 p.Asn203Lys Uncertain significance Single submitter
- CADM4 p.Asn259His Uncertain significance Single submitter
- CADM4 p.Gln78Glu Uncertain significance Single submitter
- CADM4 p.Gln8Pro Uncertain significance Single submitter
- CADM4 p.Gly280Arg Uncertain significance Single submitter
- CADM4 p.Gly2Ser Uncertain significance Single submitter
- CADM4 p.Gly327Cys Uncertain significance Single submitter
- CADM4 p.His299Arg Uncertain significance Single submitter
- CADM4 p.His299Tyr Uncertain significance Single submitter
- CADM4 p.Leu118Val Uncertain significance Single submitter
- CADM4 p.Pro10Ser Uncertain significance Single submitter
- CADM4 p.Pro266Arg Uncertain significance Single submitter
- CADM4 p.Ser179Arg Uncertain significance Single submitter
- CADM4 p.Ser283Phe Uncertain significance Single submitter
- CADM4 p.Val282Ala Uncertain significance Single submitter
- CADM4 p.Val340Leu Uncertain significance Single submitter
- CADM4 p.Val39Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CADM4 p.Ala201Thr Uncertain significance Single submitter
- CADM4 p.Ala302Pro Uncertain significance Single submitter
- CADM4 p.Ala324Thr Uncertain significance Single submitter
- CADM4 p.Ala4Thr Uncertain significance Single submitter
- CADM4 p.Ala60Asp Uncertain significance Single submitter
- CADM4 p.Arg190His Uncertain significance Single submitter
- CADM4 p.Arg257Gly Uncertain significance Single submitter
- CADM4 p.Arg90Gln Uncertain significance Single submitter
- CADM4 p.Asp192Glu Uncertain significance Single submitter
- CADM4 p.Gln48Pro Uncertain significance Single submitter
- CADM4 p.Glu164Gln Uncertain significance Single submitter
- CADM4 p.Gly2Val Uncertain significance Single submitter
- CADM4 p.Phe7Tyr Uncertain significance Single submitter
- CADM4 p.Pro207Leu Uncertain significance Single submitter
- CADM4 p.Ser223Tyr Uncertain significance Single submitter
- CADM4 p.Thr225Ala Uncertain significance Single submitter
- CADM4 p.Thr225Met Uncertain significance Single submitter
- CADM4 p.Val120Ile Uncertain significance Single submitter
- CADM4 p.Val147Ile Uncertain significance Single submitter
- CADM4 p.Val168Met Uncertain significance Single submitter
- CADM4 p.Val87Leu Uncertain significance Single submitter
All CADM4 variants
Uncertain significance 42
- p.Ala201Thr Single submitter ⚠
- p.Ala302Pro Single submitter ⚠
- p.Ala324Pro Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala60Asp Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg257Gly Single submitter ⚠
- p.Arg45Gly Single submitter ⚠
- p.Arg6Ser Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Asn203Lys Single submitter ⚠
- p.Asn259His Single submitter ⚠
- p.Asp192Glu Single submitter ⚠
- p.Gln48Pro Single submitter ⚠
- p.Gln78Glu Single submitter ⚠
- p.Gln8Pro Single submitter ⚠
- p.Glu164Gln Single submitter ⚠
- p.Gly280Arg Single submitter ⚠
- p.Gly2Ser Single submitter ⚠
- p.Gly2Val Single submitter ⚠
- p.Gly327Cys Single submitter ⚠
- p.His299Arg Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Phe7Tyr Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro266Arg Single submitter ⚠
- p.Ser179Arg Single submitter ⚠
- p.Ser223Tyr Single submitter ⚠
- p.Ser283Phe Single submitter ⚠
- p.Thr225Ala Single submitter ⚠
- p.Thr225Met Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val147Ile Single submitter ⚠
- p.Val168Met Single submitter ⚠
- p.Val282Ala Single submitter ⚠
- p.Val340Leu Single submitter ⚠
- p.Val39Ala Single submitter ⚠
- p.Val87Leu Single submitter ⚠