CADPS — 176 ClinVar variants
All ClinVar germline CADPS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →
5 Benign · 29 Likely benign · 142 Uncertain significance
Full CADPS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 140
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CADPS p.Ala1047Thr Uncertain significance Single submitter
- CADPS p.Ala1057Val Uncertain significance Single submitter
- CADPS p.Ala1114Thr Uncertain significance Single submitter
- CADPS p.Ala43Val Uncertain significance Single submitter
- CADPS p.Ala640Thr Uncertain significance Single submitter
- CADPS p.Ala650Val Uncertain significance Single submitter
- CADPS p.Ala846Val Uncertain significance Single submitter
- CADPS p.Arg1002Gln Uncertain significance Single submitter
- CADPS p.Arg1079Gln Uncertain significance Single submitter
- CADPS p.Arg1129Gln Uncertain significance Single submitter
- CADPS p.Arg1321His Uncertain significance Single submitter
- CADPS p.Arg159Gln Uncertain significance Single submitter
- CADPS p.Arg195Cys Uncertain significance Single submitter
- CADPS p.Arg208Trp Uncertain significance Single submitter
- CADPS p.Arg220Cys Uncertain significance Single submitter
- CADPS p.Arg372Cys Uncertain significance Single submitter
- CADPS p.Arg722Gly Uncertain significance Single submitter
- CADPS p.Arg785Ser Uncertain significance Single submitter
- CADPS p.Arg884His Uncertain significance Single submitter
- CADPS p.Arg959Pro Uncertain significance Single submitter
- CADPS p.Asn675Thr Uncertain significance Single submitter
- CADPS p.Asn849Ser Uncertain significance Single submitter
- CADPS p.Asp191Asn Uncertain significance Single submitter
- CADPS p.Asp191Tyr Uncertain significance Single submitter
- CADPS p.Asp393Asn Uncertain significance Single submitter
- CADPS p.Asp906His Uncertain significance Single submitter
- CADPS p.Cys841Ser Uncertain significance Single submitter
- CADPS p.Gln255Arg Uncertain significance Single submitter
- CADPS p.Gln863Arg Uncertain significance Single submitter
- CADPS p.Gln863His Uncertain significance Single submitter
- CADPS p.Glu103Ala Uncertain significance Single submitter
- CADPS p.Glu1333Asp Uncertain significance Single submitter
- CADPS p.Glu401Gln Uncertain significance Single submitter
- CADPS p.Gly227Ser Uncertain significance Single submitter
- CADPS p.Gly30Asp Uncertain significance Single submitter
- CADPS p.Gly30Ser Uncertain significance Single submitter
- CADPS p.Gly44Ser Uncertain significance Single submitter
- CADPS p.Gly532Ser Uncertain significance Single submitter
- CADPS p.Gly66Ser Uncertain significance Single submitter
- CADPS p.Gly741Asp Uncertain significance Single submitter
- CADPS p.His1282Arg Uncertain significance Single submitter
- CADPS p.His214Gln Uncertain significance Single submitter
- CADPS p.Ile378Phe Uncertain significance Single submitter
- CADPS p.Ile873Thr Uncertain significance Single submitter
- CADPS p.Leu1071Ile Uncertain significance Single submitter
- CADPS p.Leu48Arg Uncertain significance Single submitter
- CADPS p.Leu528Ser Uncertain significance Single submitter
- CADPS p.Leu814Arg Uncertain significance Single submitter
- CADPS p.Leu893Ile Uncertain significance Single submitter
- CADPS p.Lys1175Glu Uncertain significance Single submitter
- CADPS p.Lys1218Arg Uncertain significance Single submitter
- CADPS p.Lys285Asn Uncertain significance Single submitter
- CADPS p.Met317Val Uncertain significance Single submitter
- CADPS p.Pro1029Arg Uncertain significance Single submitter
- CADPS p.Pro28Gln Uncertain significance Single submitter
- CADPS p.Pro358Leu Uncertain significance Single submitter
- CADPS p.Pro765Ser Uncertain significance Single submitter
- CADPS p.Ser1332Arg Uncertain significance Single submitter
- CADPS p.Ser19Arg Uncertain significance Single submitter
- CADPS p.Ser19Asn Uncertain significance Single submitter
- CADPS p.Ser221Thr Uncertain significance Single submitter
- CADPS p.Ser42Ala Uncertain significance Single submitter
- CADPS p.Ser670Ala Uncertain significance Single submitter
- CADPS p.Thr155Ile Uncertain significance Single submitter
- CADPS p.Thr433Ile Uncertain significance Single submitter
- CADPS p.Trp945Leu Uncertain significance Single submitter
- CADPS p.Val1140Ile Uncertain significance Single submitter
- CADPS p.Val1186Ile Uncertain significance Single submitter
- CADPS p.Val1229Leu Uncertain significance Single submitter
- CADPS p.Val1248Phe Uncertain significance Single submitter
- CADPS p.Val1268Met Uncertain significance Single submitter
- CADPS p.Val193Met Uncertain significance Single submitter
- CADPS p.Val219Met Uncertain significance Single submitter
- CADPS p.Val395Met Uncertain significance Single submitter
- CADPS p.Val596Leu Uncertain significance Single submitter
- CADPS p.Val848Leu Uncertain significance Single submitter
-
CADPS p.Gly1335Arg
Uncertain significance
No assertion criteria
CADPS-related disorder
Predictors split 63
The independent predictors disagree with each other — read with care.
- CADPS p.Ala256Val Uncertain significance Single submitter
- CADPS p.Ala263Thr Uncertain significance Single submitter
- CADPS p.Ala46Thr Uncertain significance Single submitter
- CADPS p.Ala55Thr Uncertain significance Single submitter
-
CADPS p.Ala564Val
Uncertain significance
Single submitter
CADPS-related disorder
-
CADPS p.Arg1198Ile
Uncertain significance
Single submitter
CADPS-related disorder
- CADPS p.Arg309Gln Uncertain significance Single submitter
- CADPS p.Arg314His Uncertain significance Single submitter
- CADPS p.Arg323Thr Uncertain significance Single submitter
- CADPS p.Arg479Gln Uncertain significance Single submitter
- CADPS p.Arg778His Uncertain significance Single submitter
- CADPS p.Arg787Gln Uncertain significance Single submitter
- CADPS p.Arg871Trp Uncertain significance Single submitter
- CADPS p.Arg959His Uncertain significance Single submitter
- CADPS p.Asn165Asp Uncertain significance Single submitter
- CADPS p.Asn165Ser Uncertain significance Single submitter
- CADPS p.Asn955Ser Uncertain significance Single submitter
- CADPS p.Asp1228Glu Uncertain significance Single submitter
- CADPS p.Asp1353Asn Uncertain significance Single submitter
- CADPS p.Asp380Asn Uncertain significance Single submitter
- CADPS p.Gln169Pro Uncertain significance Single submitter
- CADPS p.Gln844His Uncertain significance Single submitter
- CADPS p.Glu1255Gln Uncertain significance Single submitter
- CADPS p.Glu275Asp Uncertain significance Single submitter
- CADPS p.Glu683Asp Uncertain significance Single submitter
- CADPS p.Gly50Asp Uncertain significance Single submitter
- CADPS p.Gly50Cys Uncertain significance Single submitter
- CADPS p.Gly54Val Uncertain significance Single submitter
- CADPS p.Gly65Arg Uncertain significance Single submitter
- CADPS p.Gly77Glu Uncertain significance Single submitter
- CADPS p.His761Tyr Uncertain significance Single submitter
- CADPS p.His796Tyr Uncertain significance Single submitter
- CADPS p.Leu1020Ile Uncertain significance Single submitter
- CADPS p.Lys1090Glu Uncertain significance Single submitter
- CADPS p.Met141Leu Uncertain significance Single submitter
- CADPS p.Met335Thr Uncertain significance Single submitter
- CADPS p.Phe655Leu Uncertain significance Single submitter
- CADPS p.Pro1032Gln Uncertain significance Single submitter
- CADPS p.Pro1036Thr Uncertain significance Single submitter
- CADPS p.Pro486Leu Uncertain significance Single submitter
- CADPS p.Pro4Leu Uncertain significance Single submitter
- CADPS p.Pro632Ala Uncertain significance Single submitter
- CADPS p.Pro941Leu Uncertain significance Single submitter
- CADPS p.Ser1046Leu Uncertain significance Single submitter
- CADPS p.Ser221Asn Uncertain significance Single submitter
- CADPS p.Ser373Arg Uncertain significance Single submitter
- CADPS p.Ser67Arg Uncertain significance Single submitter
- CADPS p.Ser67Asn Uncertain significance Single submitter
- CADPS p.Ser7Arg Uncertain significance Single submitter
- CADPS p.Ser947Thr Uncertain significance Single submitter
- CADPS p.Thr1122Asn Uncertain significance Single submitter
- CADPS p.Thr1288Ile Uncertain significance Single submitter
- CADPS p.Tyr184His Uncertain significance Single submitter
- CADPS p.Val1018Met Uncertain significance Single submitter
- CADPS p.Val419Ile Uncertain significance Single submitter
- CADPS p.Val419Leu Uncertain significance Single submitter
- CADPS p.Val469Ile Uncertain significance Single submitter
- CADPS p.Val545Ile Uncertain significance Single submitter
- CADPS p.Val834Ile Uncertain significance Single submitter
-
CADPS p.Ala162Thr
Uncertain significance
No assertion criteria
prostate cancer
-
CADPS p.Asn1017Ile
Likely benign
No assertion criteria
CADPS-related disorder
-
CADPS p.Leu1289Val
Uncertain significance
No assertion criteria
CADPS-related disorder
-
CADPS p.Ser1264Gly
Likely benign
No assertion criteria
CADPS-related disorder
All CADPS variants
Benign 5
- p.Ser203= Multiple submitters
- p.Tyr579= Multiple submitters
- c.1577+6T>C Single submitter
- c.2727+6T>C Single submitter
- p.Gly382= No assertion criteria CADPS-related disorder
Likely benign 29
- p.Ala69= Single submitter
- p.Asn178= Single submitter
- p.Gly20= Single submitter
- p.Leu572= Single submitter
- p.Phe286= Single submitter
- p.Pro1048= Single submitter
- c.1438-10T>C No assertion criteria CADPS-related disorder
- c.1754-6T>C No assertion criteria CADPS-related disorder
- c.3477+7A>G No assertion criteria CADPS-related disorder
- c.3883-9C>T No assertion criteria CADPS-related disorder
- p.Ala262= No assertion criteria CADPS-related disorder
- p.Ala912= No assertion criteria CADPS-related disorder
- p.Asn1017Ile No assertion criteria CADPS-related disorder ⚠
- p.Asn205= No assertion criteria CADPS-related disorder
- p.Asn740= No assertion criteria CADPS-related disorder
- p.Gly1339= No assertion criteria CADPS-related disorder
- p.Gly25= No assertion criteria CADPS-related disorder
- p.Gly47Ala No assertion criteria CADPS-related disorder
- p.Gly86= No assertion criteria CADPS-related disorder
- p.Ile129= No assertion criteria CADPS-related disorder
- p.Leu228= No assertion criteria CADPS-related disorder
- p.Lys117= No assertion criteria CADPS-related disorder
- p.Ser1264Gly No assertion criteria CADPS-related disorder ⚠
- p.Ser190= No assertion criteria CADPS-related disorder
- p.Thr1274= No assertion criteria CADPS-related disorder
- p.Thr445= No assertion criteria CADPS-related disorder
- p.Tyr656= No assertion criteria CADPS-related disorder
- p.Val394= No assertion criteria CADPS-related disorder
- p.Val685= No assertion criteria CADPS-related disorder
Uncertain significance 142
- c.3477+2T>G Single submitter CADPS-related disorder
- p.Ala1047Thr Single submitter ⚠
- p.Ala1057Val Single submitter ⚠
- p.Ala1114Thr Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala55Thr Single submitter ⚠
- p.Ala564Val Single submitter CADPS-related disorder ⚠
- p.Ala640Thr Single submitter ⚠
- p.Ala650Val Single submitter ⚠
- p.Ala846Val Single submitter ⚠
- p.Arg1002Gln Single submitter ⚠
- p.Arg1079Gln Single submitter ⚠
- p.Arg1129Gln Single submitter ⚠
- p.Arg1198Ile Single submitter CADPS-related disorder ⚠
- p.Arg1321His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg309Gln Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg323Thr Single submitter ⚠
- p.Arg372Cys Single submitter ⚠
- p.Arg479Gln Single submitter ⚠
- p.Arg722Gly Single submitter ⚠
- p.Arg778His Single submitter ⚠
- p.Arg785Ser Single submitter ⚠
- p.Arg787Gln Single submitter ⚠
- p.Arg871Trp Single submitter ⚠
- p.Arg884His Single submitter ⚠
- p.Arg959His Single submitter ⚠
- p.Arg959Pro Single submitter ⚠
- p.Asn165Asp Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asn675Thr Single submitter ⚠
- p.Asn849Ser Single submitter ⚠
- p.Asn955Ser Single submitter ⚠
- p.Asp1228Glu Single submitter ⚠
- p.Asp1353Asn Single submitter ⚠
- p.Asp191Asn Single submitter ⚠
- p.Asp191Tyr Single submitter ⚠
- p.Asp380Asn Single submitter ⚠
- p.Asp393Asn Single submitter ⚠
- p.Asp906His Single submitter ⚠
- p.Cys841Ser Single submitter ⚠
- p.Gln1260= Single submitter CADPS-related disorder
- p.Gln169Pro Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln844His Single submitter ⚠
- p.Gln863Arg Single submitter ⚠
- p.Gln863His Single submitter ⚠
- p.Glu103Ala Single submitter ⚠
- p.Glu1255Gln Single submitter ⚠
- p.Glu1333Asp Single submitter ⚠
- p.Glu275Asp Single submitter ⚠
- p.Glu401Gln Single submitter ⚠
- p.Glu683Asp Single submitter ⚠
- p.Gly227Ser Single submitter ⚠
- p.Gly30Asp Single submitter ⚠
- p.Gly30Ser Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.Gly50Asp Single submitter ⚠
- p.Gly50Cys Single submitter ⚠
- p.Gly532Ser Single submitter ⚠
- p.Gly54Val Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Gly741Asp Single submitter ⚠
- p.Gly77Glu Single submitter ⚠
- p.His1282Arg Single submitter ⚠
- p.His214Gln Single submitter ⚠
- p.His761Tyr Single submitter ⚠
- p.His796Tyr Single submitter ⚠
- p.Ile1269fs Single submitter CADPS-related disorder
- p.Ile378Phe Single submitter ⚠
- p.Ile873Thr Single submitter ⚠
- p.Leu1020Ile Single submitter ⚠
- p.Leu1071Ile Single submitter ⚠
- p.Leu48Arg Single submitter ⚠
- p.Leu528Ser Single submitter ⚠
- p.Leu814Arg Single submitter ⚠
- p.Leu893Ile Single submitter ⚠
- p.Lys1090Glu Single submitter ⚠
- p.Lys1165_Ile1166insTer Single submitter
- p.Lys1175Glu Single submitter ⚠
- p.Lys1218Arg Single submitter ⚠
- p.Lys285Asn Single submitter ⚠
- p.Met141Leu Single submitter ⚠
- p.Met317Val Single submitter ⚠
- p.Met335Thr Single submitter ⚠
- p.Phe655Leu Single submitter ⚠
- p.Pro1029Arg Single submitter ⚠
- p.Pro1032Gln Single submitter ⚠
- p.Pro1036Thr Single submitter ⚠
- p.Pro28Gln Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Pro486Leu Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Pro632Ala Single submitter ⚠
- p.Pro765Ser Single submitter ⚠
- p.Pro941Leu Single submitter ⚠
- p.Ser1046Leu Single submitter ⚠
- p.Ser1332Arg Single submitter ⚠
- p.Ser19Arg Single submitter ⚠
- p.Ser19Asn Single submitter ⚠
- p.Ser221Asn Single submitter ⚠
- p.Ser221Thr Single submitter ⚠
- p.Ser373Arg Single submitter ⚠
- p.Ser42Ala Single submitter ⚠
- p.Ser670Ala Single submitter ⚠
- p.Ser67Arg Single submitter ⚠
- p.Ser67Asn Single submitter ⚠
- p.Ser7Arg Single submitter ⚠
- p.Ser947Thr Single submitter ⚠
- p.Thr1122Asn Single submitter ⚠
- p.Thr1288Ile Single submitter ⚠
- p.Thr155Ile Single submitter ⚠
- p.Thr433Ile Single submitter ⚠
- p.Trp945Leu Single submitter ⚠
- p.Tyr184His Single submitter ⚠
- p.Val1018Met Single submitter ⚠
- p.Val1140Ile Single submitter ⚠
- p.Val1186Ile Single submitter ⚠
- p.Val1229Leu Single submitter ⚠
- p.Val1248Phe Single submitter ⚠
- p.Val1268Met Single submitter ⚠
- p.Val193Met Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val395Met Single submitter ⚠
- p.Val419Ile Single submitter ⚠
- p.Val419Leu Single submitter ⚠
- p.Val469Ile Single submitter ⚠
- p.Val545Ile Single submitter ⚠
- p.Val596Leu Single submitter ⚠
- p.Val834Ile Single submitter ⚠
- p.Val848Leu Single submitter ⚠
- p.Ala162Thr No assertion criteria prostate cancer ⚠
- p.Gly1335Arg No assertion criteria CADPS-related disorder ⚠
- p.Leu1289Val No assertion criteria CADPS-related disorder ⚠