CALB2 — 41 ClinVar variants
All ClinVar germline CALB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 39 Uncertain significance
Full CALB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALB2 p.Ala115Val Uncertain significance Single submitter
- CALB2 p.Arg145Gln Uncertain significance Single submitter
- CALB2 p.Arg161Gln Uncertain significance Single submitter
- CALB2 p.Arg258Cys Uncertain significance Single submitter
- CALB2 p.Asn231Ser Uncertain significance Single submitter
- CALB2 p.Asn236Ser Uncertain significance Single submitter
- CALB2 p.Asp138His Uncertain significance Single submitter
- CALB2 p.Glu184Lys Uncertain significance Single submitter
- CALB2 p.Glu198Lys Uncertain significance Single submitter
- CALB2 p.Glu229Lys Uncertain significance Single submitter
- CALB2 p.Glu40Gly Uncertain significance Single submitter
- CALB2 p.Gly107Val Uncertain significance Single submitter
- CALB2 p.Gly167Arg Uncertain significance Single submitter
- CALB2 p.Gly192Asp Uncertain significance Single submitter
- CALB2 p.Gly34Arg Uncertain significance Single submitter
- CALB2 p.Ile159Thr Uncertain significance Single submitter
- CALB2 p.Ile215Thr Uncertain significance Single submitter
- CALB2 p.Ile263Thr Uncertain significance Single submitter
- CALB2 p.Leu100Pro Uncertain significance Single submitter
- CALB2 p.Leu140Pro Uncertain significance Single submitter
- CALB2 p.Leu250Ser Uncertain significance Single submitter
- CALB2 p.Leu250Val Uncertain significance Single submitter
- CALB2 p.Lys259Arg Uncertain significance Single submitter
- CALB2 p.Met57Thr Uncertain significance Single submitter
- CALB2 p.Ser246Arg Uncertain significance Single submitter
- CALB2 p.Thr158Ala Uncertain significance Single submitter
- CALB2 p.Tyr228Cys Uncertain significance Single submitter
- CALB2 p.Val247Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CALB2 p.Ala129Val Uncertain significance Single submitter
- CALB2 p.Arg145Leu Uncertain significance Single submitter
- CALB2 p.Gln157His Uncertain significance Single submitter
- CALB2 p.Gln183Arg Uncertain significance Single submitter
- CALB2 p.Glu217Lys Uncertain significance Single submitter
- CALB2 p.Glu95Gln Uncertain significance Single submitter
- CALB2 p.Glu96Asp Uncertain significance Single submitter
- CALB2 p.Leu188Phe Uncertain significance Single submitter
- CALB2 p.Pro146Arg Uncertain significance Single submitter
- CALB2 p.Tyr257Cys Uncertain significance Single submitter
- CALB2 p.Val106Ala Uncertain significance Single submitter
All CALB2 variants
Uncertain significance 39
- p.Ala115Val Single submitter ⚠
- p.Ala129Val Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg145Leu Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg258Cys Single submitter ⚠
- p.Asn231Ser Single submitter ⚠
- p.Asn236Ser Single submitter ⚠
- p.Asp138His Single submitter ⚠
- p.Gln157His Single submitter ⚠
- p.Gln183Arg Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Glu198Lys Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Glu40Gly Single submitter ⚠
- p.Glu95Gln Single submitter ⚠
- p.Glu96Asp Single submitter ⚠
- p.Gly107Val Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly192Asp Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Ile159Thr Single submitter ⚠
- p.Ile215Thr Single submitter ⚠
- p.Ile263Thr Single submitter ⚠
- p.Leu100Pro Single submitter ⚠
- p.Leu140Pro Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu250Ser Single submitter ⚠
- p.Leu250Val Single submitter ⚠
- p.Lys259Arg Single submitter ⚠
- p.Met57Thr Single submitter ⚠
- p.Pro146Arg Single submitter ⚠
- p.Ser246Arg Single submitter ⚠
- p.Thr158Ala Single submitter ⚠
- p.Tyr228Cys Single submitter ⚠
- p.Tyr257Cys Single submitter ⚠
- p.Val106Ala Single submitter ⚠
- p.Val247Ile Single submitter ⚠