CALCA — 33 ClinVar variants
All ClinVar germline CALCA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Benign · 1 Likely benign · 29 Uncertain significance
Full CALCA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALCA p.Ala11Thr Uncertain significance Single submitter
- CALCA p.Ala31Ser Uncertain significance Single submitter
- CALCA p.Arg84Pro Uncertain significance Single submitter
- CALCA p.Gln108Lys Uncertain significance Single submitter
- CALCA p.Gln138His Uncertain significance Single submitter
- CALCA p.His133Pro Uncertain significance Single submitter
- CALCA p.Met136Thr Uncertain significance Single submitter
- CALCA p.Met92Ile Uncertain significance Single submitter
- CALCA p.Pro137Ser Uncertain significance Single submitter
- CALCA p.Pro137Thr Uncertain significance Single submitter
- CALCA p.Pro36Thr Uncertain significance Single submitter
- CALCA p.Val16Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CALCA p.Ala47Pro Uncertain significance Single submitter
- CALCA p.Ala47Val Uncertain significance Single submitter
- CALCA p.Arg84Gln Uncertain significance Single submitter
- CALCA p.Gly112Trp Uncertain significance Single submitter
- CALCA p.Gly21Asp Uncertain significance Single submitter
- CALCA p.Leu17Pro Uncertain significance Single submitter
- CALCA p.Leu18Met Uncertain significance Single submitter
- CALCA p.Ser30Cys Uncertain significance Single submitter
- CALCA p.Thr41Met Uncertain significance Single submitter
All CALCA variants
Benign 3
- p.Phe106= Multiple submitters
- p.Leu126= Single submitter
- c.228-215= No assertion criteria Calcitonin polymorphism
Likely benign 1
- p.Asp45Glu Single submitter
Uncertain significance 29
- p.Ala118Val Single submitter
- p.Ala11Thr Single submitter ⚠
- p.Ala31Ser Single submitter ⚠
- p.Ala47Pro Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Arg123Cys Single submitter
- p.Arg84Gln Single submitter ⚠
- p.Arg84Pro Single submitter ⚠
- p.Arg93Gln Single submitter
- p.Arg93Trp Single submitter
- p.Asp125Glu Single submitter
- p.Gln108Lys Single submitter ⚠
- p.Gln138His Single submitter ⚠
- p.Gly112Trp Single submitter ⚠
- p.Gly115Asp Single submitter
- p.Gly21Asp Single submitter ⚠
- p.His133Pro Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Leu18Met Single submitter ⚠
- p.Met136Thr Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Pro111Thr Single submitter
- p.Pro137Ser Single submitter ⚠
- p.Pro137Thr Single submitter ⚠
- p.Pro36Thr Single submitter ⚠
- p.Ser30Cys Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Thr91Asn Single submitter
- p.Val16Ile Single submitter ⚠