CALCOCO1 — 99 ClinVar variants
All ClinVar germline CALCOCO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
7 Likely benign · 92 Uncertain significance
Full CALCOCO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALCOCO1 p.Gln112Lys Uncertain significance Multiple submitters
- CALCOCO1 p.Ala303Thr Uncertain significance Single submitter
- CALCOCO1 p.Ala303Val Uncertain significance Single submitter
- CALCOCO1 p.Ala322Val Uncertain significance Single submitter
- CALCOCO1 p.Ala369Thr Uncertain significance Single submitter
- CALCOCO1 p.Ala395Thr Uncertain significance Single submitter
- CALCOCO1 p.Ala519Thr Uncertain significance Single submitter
- CALCOCO1 p.Ala565Val Uncertain significance Single submitter
- CALCOCO1 p.Arg105His Uncertain significance Single submitter
- CALCOCO1 p.Arg12Cys Uncertain significance Single submitter
- CALCOCO1 p.Arg180Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg192Met Uncertain significance Single submitter
- CALCOCO1 p.Arg22Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg316Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg334Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg346Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg373Lys Uncertain significance Single submitter
- CALCOCO1 p.Arg375Cys Uncertain significance Single submitter
- CALCOCO1 p.Arg375His Uncertain significance Single submitter
- CALCOCO1 p.Arg382Cys Uncertain significance Single submitter
- CALCOCO1 p.Arg382His Uncertain significance Single submitter
- CALCOCO1 p.Arg382Leu Uncertain significance Single submitter
- CALCOCO1 p.Arg384His Uncertain significance Single submitter
- CALCOCO1 p.Arg456Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg456Trp Uncertain significance Single submitter
- CALCOCO1 p.Arg470Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg506His Uncertain significance Single submitter
- CALCOCO1 p.Arg568Gln Uncertain significance Single submitter
- CALCOCO1 p.Arg8Gln Uncertain significance Single submitter
- CALCOCO1 p.Asn161Ser Uncertain significance Single submitter
- CALCOCO1 p.Asp134Glu Uncertain significance Single submitter
- CALCOCO1 p.Asp319Val Uncertain significance Single submitter
- CALCOCO1 p.Asp523Asn Uncertain significance Single submitter
- CALCOCO1 p.Asp559Asn Uncertain significance Single submitter
- CALCOCO1 p.Asp559Glu Uncertain significance Single submitter
- CALCOCO1 p.Asp677Gly Uncertain significance Single submitter
- CALCOCO1 p.Cys110Tyr Uncertain significance Single submitter
- CALCOCO1 p.Cys532Phe Uncertain significance Single submitter
- CALCOCO1 p.Glu183Asp Uncertain significance Single submitter
- CALCOCO1 p.Glu194Lys Uncertain significance Single submitter
- CALCOCO1 p.Glu308Gln Uncertain significance Single submitter
- CALCOCO1 p.Glu453Lys Uncertain significance Single submitter
- CALCOCO1 p.Glu491Val Uncertain significance Single submitter
- CALCOCO1 p.Glu642Gly Uncertain significance Single submitter
- CALCOCO1 p.Glu691Gln Uncertain significance Single submitter
- CALCOCO1 p.Gly329Asp Uncertain significance Single submitter
- CALCOCO1 p.Gly329Val Uncertain significance Single submitter
- CALCOCO1 p.Gly398Cys Uncertain significance Single submitter
- CALCOCO1 p.Gly553Asp Uncertain significance Single submitter
- CALCOCO1 p.Gly613Arg Uncertain significance Single submitter
- CALCOCO1 p.Gly646Arg Uncertain significance Single submitter
- CALCOCO1 p.His294Gln Uncertain significance Single submitter
- CALCOCO1 p.His295Gln Uncertain significance Single submitter
- CALCOCO1 p.His400Arg Uncertain significance Single submitter
- CALCOCO1 p.His585Arg Uncertain significance Single submitter
- CALCOCO1 p.Ile212Thr Uncertain significance Single submitter
- CALCOCO1 p.Lys243Glu Uncertain significance Single submitter
- CALCOCO1 p.Met324Ile Uncertain significance Single submitter
- CALCOCO1 p.Met500Ile Uncertain significance Single submitter
- CALCOCO1 p.Pro115Ser Uncertain significance Single submitter
- CALCOCO1 p.Pro589Ser Uncertain significance Single submitter
- CALCOCO1 p.Pro70Ser Uncertain significance Single submitter
- CALCOCO1 p.Pro78Arg Uncertain significance Single submitter
- CALCOCO1 p.Pro91Ser Uncertain significance Single submitter
- CALCOCO1 p.Ser311Arg Uncertain significance Single submitter
- CALCOCO1 p.Ser562Phe Uncertain significance Single submitter
- CALCOCO1 p.Ser612Asn Uncertain significance Single submitter
- CALCOCO1 p.Thr196Met Uncertain significance Single submitter
- CALCOCO1 p.Thr23Ile Uncertain significance Single submitter
- CALCOCO1 p.Thr650Asn Uncertain significance Single submitter
- CALCOCO1 p.Thr684Asn Uncertain significance Single submitter
- CALCOCO1 p.Tyr552Ser Uncertain significance Single submitter
- CALCOCO1 p.Tyr629Cys Uncertain significance Single submitter
- CALCOCO1 p.Val148Leu Uncertain significance Single submitter
- CALCOCO1 p.Val69Met Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CALCOCO1 p.Ala478Asp Uncertain significance Single submitter
- CALCOCO1 p.Arg160Trp Uncertain significance Single submitter
- CALCOCO1 p.Arg22Trp Uncertain significance Single submitter
- CALCOCO1 p.Arg384Ser Uncertain significance Single submitter
- CALCOCO1 p.Arg506Cys Uncertain significance Single submitter
- CALCOCO1 p.Arg506Leu Uncertain significance Single submitter
- CALCOCO1 p.Asp319Tyr Uncertain significance Single submitter
- CALCOCO1 p.Asp538Glu Uncertain significance Single submitter
- CALCOCO1 p.Gln315Pro Uncertain significance Single submitter
- CALCOCO1 p.Glu655Lys Uncertain significance Single submitter
- CALCOCO1 p.Gly625Arg Uncertain significance Single submitter
- CALCOCO1 p.Leu300Met Uncertain significance Single submitter
- CALCOCO1 p.Met164Ile Uncertain significance Single submitter
- CALCOCO1 p.Pro115Arg Uncertain significance Single submitter
- CALCOCO1 p.Ser45Arg Uncertain significance Single submitter
- CALCOCO1 p.Ser595Phe Uncertain significance Single submitter
- CALCOCO1 p.Val605Gly Uncertain significance Single submitter
-
CALCOCO1 p.Arg334Trp
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All CALCOCO1 variants
Likely benign 7
- p.Ala371Thr Single submitter
- p.Arg557His Single submitter
- p.Gly398Ser Single submitter
- p.Leu153= Single submitter
- p.Phe450Leu Single submitter
- p.Thr520Ala Single submitter
- p.Arg334Trp No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 92
- p.Gln112Lys Multiple submitters ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala303Val Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Ala369Thr Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala478Asp Single submitter ⚠
- p.Ala519Thr Single submitter ⚠
- p.Ala565Val Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg12Cys Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg180Gln Single submitter ⚠
- p.Arg192Met Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg22Trp Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg373Lys Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg382Cys Single submitter ⚠
- p.Arg382His Single submitter ⚠
- p.Arg382Leu Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg384Ser Single submitter ⚠
- p.Arg456Gln Single submitter ⚠
- p.Arg456Trp Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg506Cys Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Arg506Leu Single submitter ⚠
- p.Arg568Gln Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asp134Glu Single submitter ⚠
- p.Asp319Tyr Single submitter ⚠
- p.Asp319Val Single submitter ⚠
- p.Asp523Asn Single submitter ⚠
- p.Asp538Glu Single submitter ⚠
- p.Asp559Asn Single submitter ⚠
- p.Asp559Glu Single submitter ⚠
- p.Asp677Gly Single submitter ⚠
- p.Cys110Tyr Single submitter ⚠
- p.Cys532Phe Single submitter ⚠
- p.Gln315Pro Single submitter ⚠
- p.Glu183Asp Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu308Gln Single submitter ⚠
- p.Glu453Lys Single submitter ⚠
- p.Glu491Val Single submitter ⚠
- p.Glu642Gly Single submitter ⚠
- p.Glu655Lys Single submitter ⚠
- p.Glu691Gln Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Gly329Val Single submitter ⚠
- p.Gly398Cys Single submitter ⚠
- p.Gly553Asp Single submitter ⚠
- p.Gly613Arg Single submitter ⚠
- p.Gly625Arg Single submitter ⚠
- p.Gly646Arg Single submitter ⚠
- p.His294Gln Single submitter ⚠
- p.His295Gln Single submitter ⚠
- p.His400Arg Single submitter ⚠
- p.His585Arg Single submitter ⚠
- p.Ile212Thr Single submitter ⚠
- p.Leu300Met Single submitter ⚠
- p.Lys243Glu Single submitter ⚠
- p.Met164Ile Single submitter ⚠
- p.Met324Ile Single submitter ⚠
- p.Met500Ile Single submitter ⚠
- p.Pro115Arg Single submitter ⚠
- p.Pro115Ser Single submitter ⚠
- p.Pro589Ser Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Pro78Arg Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser311Arg Single submitter ⚠
- p.Ser45Arg Single submitter ⚠
- p.Ser562Phe Single submitter ⚠
- p.Ser595Phe Single submitter ⚠
- p.Ser612Asn Single submitter ⚠
- p.Thr196Met Single submitter ⚠
- p.Thr23Ile Single submitter ⚠
- p.Thr650Asn Single submitter ⚠
- p.Thr684Asn Single submitter ⚠
- p.Tyr552Ser Single submitter ⚠
- p.Tyr629Cys Single submitter ⚠
- p.Val148Leu Single submitter ⚠
- p.Val605Gly Single submitter ⚠
- p.Val69Met Single submitter ⚠