CALD1 — 119 ClinVar variants
All ClinVar germline CALD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
6 Benign · 10 Likely benign · 103 Uncertain significance
Full CALD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALD1 p.Ala373Thr Uncertain significance Single submitter
- CALD1 p.Ala37Glu Uncertain significance Single submitter
- CALD1 p.Ala446Thr Uncertain significance Single submitter
- CALD1 p.Ala517Gly Uncertain significance Single submitter
- CALD1 p.Ala517Thr Uncertain significance Single submitter
- CALD1 p.Ala561Val Uncertain significance Single submitter
- CALD1 p.Ala613Gly Uncertain significance Single submitter
- CALD1 p.Ala692Thr Uncertain significance Single submitter
- CALD1 p.Arg107His Uncertain significance Single submitter
- CALD1 p.Arg117Trp Uncertain significance Single submitter
- CALD1 p.Arg12Ser Uncertain significance Single submitter
- CALD1 p.Arg159Lys Uncertain significance Single submitter
- CALD1 p.Arg178Thr Uncertain significance Single submitter
- CALD1 p.Arg42His Uncertain significance Single submitter
- CALD1 p.Arg49Gln Uncertain significance Single submitter
- CALD1 p.Arg49Trp Uncertain significance Single submitter
- CALD1 p.Arg745Cys Uncertain significance Single submitter
- CALD1 p.Arg776Trp Uncertain significance Single submitter
- CALD1 p.Arg7Cys Uncertain significance Single submitter
- CALD1 p.Arg7His Uncertain significance Single submitter
- CALD1 p.Arg99Leu Uncertain significance Single submitter
- CALD1 p.Asp127Asn Uncertain significance Single submitter
- CALD1 p.Gln87Glu Uncertain significance Single submitter
- CALD1 p.Glu105Lys Uncertain significance Single submitter
- CALD1 p.Glu150Lys Uncertain significance Single submitter
- CALD1 p.Glu158Lys Uncertain significance Single submitter
- CALD1 p.Glu161Lys Uncertain significance Single submitter
- CALD1 p.Glu245Gln Uncertain significance Single submitter
- CALD1 p.Glu407Lys Uncertain significance Single submitter
- CALD1 p.Glu477Asp Uncertain significance Single submitter
- CALD1 p.Glu573Lys Uncertain significance Single submitter
- CALD1 p.Glu707Asp Uncertain significance Single submitter
- CALD1 p.Glu780Lys Uncertain significance Single submitter
- CALD1 p.Gly406Ala Uncertain significance Single submitter
- CALD1 p.Gly487Glu Uncertain significance Single submitter
- CALD1 p.Gly514Glu Uncertain significance Single submitter
- CALD1 p.Gly719Arg Uncertain significance Single submitter
- CALD1 p.His501Asn Uncertain significance Single submitter
- CALD1 p.His501Gln Uncertain significance Single submitter
- CALD1 p.Ile468Met Uncertain significance Single submitter
- CALD1 p.Ile675Thr Uncertain significance Single submitter
- CALD1 p.Leu132Phe Uncertain significance Single submitter
- CALD1 p.Lys287Gln Uncertain significance Single submitter
- CALD1 p.Lys450Asn Uncertain significance Single submitter
- CALD1 p.Met226Thr Uncertain significance Single submitter
- CALD1 p.Pro198Arg Uncertain significance Single submitter
- CALD1 p.Pro474Ser Uncertain significance Single submitter
- CALD1 p.Pro764His Uncertain significance Single submitter
- CALD1 p.Ser131Leu Uncertain significance Single submitter
- CALD1 p.Ser665Leu Uncertain significance Single submitter
- CALD1 p.Ser677Asn Uncertain significance Single submitter
- CALD1 p.Tyr160His Uncertain significance Single submitter
- CALD1 p.Tyr682His Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- CALD1 p.Ala324Glu Benign Multiple submitters
- CALD1 p.Asp122Asn Likely benign Multiple submitters
- CALD1 p.Glu77Lys Benign Multiple submitters
- CALD1 p.Ser171Phe Benign Multiple submitters
- CALD1 p.Ala265Thr Uncertain significance Single submitter
- CALD1 p.Ala282Val Uncertain significance Single submitter
- CALD1 p.Ala303Ser Uncertain significance Single submitter
- CALD1 p.Ala562Val Likely benign Single submitter
- CALD1 p.Ala698Glu Uncertain significance Single submitter
- CALD1 p.Arg156Cys Uncertain significance Single submitter
- CALD1 p.Arg316Ser Uncertain significance Single submitter
- CALD1 p.Arg330Lys Uncertain significance Single submitter
- CALD1 p.Arg351Trp Uncertain significance Single submitter
- CALD1 p.Arg388His Uncertain significance Single submitter
- CALD1 p.Arg540His Uncertain significance Single submitter
- CALD1 p.Arg99His Uncertain significance Single submitter
- CALD1 p.Asp92His Uncertain significance Single submitter
- CALD1 p.Asp92Val Uncertain significance Single submitter
- CALD1 p.Glu120Ala Uncertain significance Single submitter
- CALD1 p.Glu242Lys Uncertain significance Single submitter
- CALD1 p.Glu362Lys Uncertain significance Single submitter
- CALD1 p.Glu363Asp Uncertain significance Single submitter
- CALD1 p.Glu384Gly Uncertain significance Single submitter
- CALD1 p.Glu385Lys Uncertain significance Single submitter
- CALD1 p.Glu394Lys Uncertain significance Single submitter
- CALD1 p.Glu439Gln Uncertain significance Single submitter
- CALD1 p.Glu477Val Uncertain significance Single submitter
- CALD1 p.Glu552Gln Uncertain significance Single submitter
- CALD1 p.Glu55Lys Uncertain significance Single submitter
- CALD1 p.Glu56Lys Uncertain significance Single submitter
- CALD1 p.Glu648Lys Uncertain significance Single submitter
- CALD1 p.Gly406Arg Uncertain significance Single submitter
- CALD1 p.Gly544Arg Uncertain significance Single submitter
- CALD1 p.Gly662Arg Uncertain significance Single submitter
- CALD1 p.Ile288Thr Uncertain significance Single submitter
- CALD1 p.Lys119Arg Uncertain significance Single submitter
- CALD1 p.Lys14Asn Uncertain significance Single submitter
- CALD1 p.Lys346Arg Uncertain significance Single submitter
- CALD1 p.Lys360Ile Uncertain significance Single submitter
- CALD1 p.Lys459Ile Uncertain significance Single submitter
- CALD1 p.Lys464Arg Uncertain significance Single submitter
- CALD1 p.Lys467Thr Uncertain significance Single submitter
- CALD1 p.Lys475Arg Uncertain significance Single submitter
- CALD1 p.Lys775Arg Uncertain significance Single submitter
- CALD1 p.Phe634Leu Uncertain significance Single submitter
- CALD1 p.Pro697Leu Uncertain significance Single submitter
- CALD1 p.Pro762Leu Uncertain significance Single submitter
- CALD1 p.Ser511Arg Uncertain significance Single submitter
- CALD1 p.Ser684Thr Uncertain significance Single submitter
- CALD1 p.Ser765Phe Uncertain significance Single submitter
- CALD1 p.Ser774Gly Likely benign Single submitter
- CALD1 p.Thr489Ile Uncertain significance Single submitter
- CALD1 p.Thr689Arg Uncertain significance Single submitter
- CALD1 p.Val432Phe Uncertain significance Single submitter
- CALD1 p.Val68Met Uncertain significance Single submitter
- CALD1 p.Val772Ile Uncertain significance Single submitter
All CALD1 variants
Benign 6
- p.Ala324Glu Multiple submitters ⚠
- p.Glu77Lys Multiple submitters ⚠
- p.Ile671Val Multiple submitters
- p.Ser171Phe Multiple submitters ⚠
- p.Arg136Lys Single submitter
- p.Met317Ile Single submitter
Likely benign 10
- p.Asp122Asn Multiple submitters ⚠
- p.Met257Ile Multiple submitters
- p.Ala562Val Single submitter ⚠
- p.Arg586Lys Single submitter
- p.Asp249Glu Single submitter
- p.Glu321del Single submitter
- p.Lys360= Single submitter
- p.Ser660= Single submitter
- p.Ser665= Single submitter
- p.Ser774Gly Single submitter ⚠
Uncertain significance 103
- p.Ala265Thr Single submitter ⚠
- p.Ala282Val Single submitter ⚠
- p.Ala303Ser Single submitter ⚠
- p.Ala373Thr Single submitter ⚠
- p.Ala37Glu Single submitter ⚠
- p.Ala446Thr Single submitter ⚠
- p.Ala517Gly Single submitter ⚠
- p.Ala517Thr Single submitter ⚠
- p.Ala561Val Single submitter ⚠
- p.Ala613Gly Single submitter ⚠
- p.Ala692Thr Single submitter ⚠
- p.Ala698Glu Single submitter ⚠
- p.Arg107His Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Arg12Ser Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg159Lys Single submitter ⚠
- p.Arg178Thr Single submitter ⚠
- p.Arg316Ser Single submitter ⚠
- p.Arg330Lys Single submitter ⚠
- p.Arg351Trp Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg42His Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg540His Single submitter ⚠
- p.Arg745Cys Single submitter ⚠
- p.Arg776Trp Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Arg7His Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Arg99Leu Single submitter ⚠
- p.Asp127Asn Single submitter ⚠
- p.Asp92His Single submitter ⚠
- p.Asp92Val Single submitter ⚠
- p.Gln87Glu Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu120Ala Single submitter ⚠
- p.Glu150Lys Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Glu161Lys Single submitter ⚠
- p.Glu242Lys Single submitter ⚠
- p.Glu245Gln Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu363Asp Single submitter ⚠
- p.Glu384Gly Single submitter ⚠
- p.Glu385Lys Single submitter ⚠
- p.Glu394Lys Single submitter ⚠
- p.Glu407Lys Single submitter ⚠
- p.Glu439Gln Single submitter ⚠
- p.Glu477Asp Single submitter ⚠
- p.Glu477Val Single submitter ⚠
- p.Glu552Gln Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Glu56Lys Single submitter ⚠
- p.Glu573Lys Single submitter ⚠
- p.Glu648Lys Single submitter ⚠
- p.Glu707Asp Single submitter ⚠
- p.Glu780Lys Single submitter ⚠
- p.Gly406Ala Single submitter ⚠
- p.Gly406Arg Single submitter ⚠
- p.Gly487Glu Single submitter ⚠
- p.Gly514Glu Single submitter ⚠
- p.Gly544Arg Single submitter ⚠
- p.Gly662Arg Single submitter ⚠
- p.Gly719Arg Single submitter ⚠
- p.His501Asn Single submitter ⚠
- p.His501Gln Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile468Met Single submitter ⚠
- p.Ile675Thr Single submitter ⚠
- p.Leu132Phe Single submitter ⚠
- p.Lys119Arg Single submitter ⚠
- p.Lys14Asn Single submitter ⚠
- p.Lys287Gln Single submitter ⚠
- p.Lys346Arg Single submitter ⚠
- p.Lys360Ile Single submitter ⚠
- p.Lys450Asn Single submitter ⚠
- p.Lys459Ile Single submitter ⚠
- p.Lys464Arg Single submitter ⚠
- p.Lys467Thr Single submitter ⚠
- p.Lys475Arg Single submitter ⚠
- p.Lys775Arg Single submitter ⚠
- p.Met226Thr Single submitter ⚠
- p.Phe634Leu Single submitter ⚠
- p.Pro198Arg Single submitter ⚠
- p.Pro474Ser Single submitter ⚠
- p.Pro697Leu Single submitter ⚠
- p.Pro762Leu Single submitter ⚠
- p.Pro764His Single submitter ⚠
- p.Ser131Leu Single submitter ⚠
- p.Ser511Arg Single submitter ⚠
- p.Ser665Leu Single submitter ⚠
- p.Ser677Asn Single submitter ⚠
- p.Ser684Thr Single submitter ⚠
- p.Ser765Phe Single submitter ⚠
- p.Thr489Ile Single submitter ⚠
- p.Thr689Arg Single submitter ⚠
- p.Tyr160His Single submitter ⚠
- p.Tyr682His Single submitter ⚠
- p.Val432Phe Single submitter ⚠
- p.Val68Met Single submitter ⚠
- p.Val772Ile Single submitter ⚠