CALHM2 — 62 ClinVar variants
All ClinVar germline CALHM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
62 Uncertain significance
Full CALHM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALHM2 p.Ala110Val Uncertain significance Single submitter
- CALHM2 p.Ala311Val Uncertain significance Single submitter
- CALHM2 p.Ala97Thr Uncertain significance Single submitter
- CALHM2 p.Arg224Cys Uncertain significance Single submitter
- CALHM2 p.Arg233His Uncertain significance Single submitter
- CALHM2 p.Arg288Cys Uncertain significance Single submitter
- CALHM2 p.Arg52Gln Uncertain significance Single submitter
- CALHM2 p.Asn257Ser Uncertain significance Single submitter
- CALHM2 p.Asp314Asn Uncertain significance Single submitter
- CALHM2 p.Cys130Tyr Uncertain significance Single submitter
- CALHM2 p.Gln277Arg Uncertain significance Single submitter
- CALHM2 p.Glu164Asp Uncertain significance Single submitter
- CALHM2 p.Glu85Gln Uncertain significance Single submitter
- CALHM2 p.Glu85Lys Uncertain significance Single submitter
- CALHM2 p.Gly271Ser Uncertain significance Single submitter
- CALHM2 p.Gly57Arg Uncertain significance Single submitter
- CALHM2 p.Gly62Arg Uncertain significance Single submitter
- CALHM2 p.Gly62Ser Uncertain significance Single submitter
- CALHM2 p.His78Asn Uncertain significance Single submitter
- CALHM2 p.Leu205Phe Uncertain significance Single submitter
- CALHM2 p.Leu212Phe Uncertain significance Single submitter
- CALHM2 p.Leu212Pro Uncertain significance Single submitter
- CALHM2 p.Leu299Arg Uncertain significance Single submitter
- CALHM2 p.Pro138Leu Uncertain significance Single submitter
- CALHM2 p.Pro50Leu Uncertain significance Single submitter
- CALHM2 p.Ser184Phe Uncertain significance Single submitter
- CALHM2 p.Thr142Met Uncertain significance Single submitter
- CALHM2 p.Thr272Met Uncertain significance Single submitter
- CALHM2 p.Trp117Cys Uncertain significance Single submitter
- CALHM2 p.Trp220Arg Uncertain significance Single submitter
- CALHM2 p.Tyr128His Uncertain significance Single submitter
- CALHM2 p.Val136Met Uncertain significance Single submitter
- CALHM2 p.Val194Leu Uncertain significance Single submitter
- CALHM2 p.Val237Glu Uncertain significance Single submitter
- CALHM2 p.Val269Ala Uncertain significance Single submitter
- CALHM2 p.Val284Ile Uncertain significance Single submitter
- CALHM2 p.Val316Leu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CALHM2 p.Ala243Thr Uncertain significance Single submitter
- CALHM2 p.Ala59Val Uncertain significance Single submitter
- CALHM2 p.Arg109Cys Uncertain significance Single submitter
- CALHM2 p.Arg109His Uncertain significance Single submitter
- CALHM2 p.Arg10His Uncertain significance Single submitter
- CALHM2 p.Arg173Pro Uncertain significance Single submitter
- CALHM2 p.Arg178Cys Uncertain significance Single submitter
- CALHM2 p.Arg178His Uncertain significance Single submitter
- CALHM2 p.Arg179Gly Uncertain significance Single submitter
- CALHM2 p.Arg215Cys Uncertain significance Single submitter
- CALHM2 p.Arg233Pro Uncertain significance Single submitter
- CALHM2 p.Glu236Lys Uncertain significance Single submitter
- CALHM2 p.Glu37Ala Uncertain significance Single submitter
- CALHM2 p.Gly26Ser Uncertain significance Single submitter
- CALHM2 p.Leu191Phe Uncertain significance Single submitter
- CALHM2 p.Leu198Pro Uncertain significance Single submitter
- CALHM2 p.Leu321Phe Uncertain significance Single submitter
- CALHM2 p.Phe100Leu Uncertain significance Single submitter
- CALHM2 p.Phe11Val Uncertain significance Single submitter
- CALHM2 p.Phe148Leu Uncertain significance Single submitter
- CALHM2 p.Phe172Leu Uncertain significance Single submitter
- CALHM2 p.Phe200Leu Uncertain significance Single submitter
- CALHM2 p.Phe267Leu Uncertain significance Single submitter
- CALHM2 p.Trp220Leu Uncertain significance Single submitter
- CALHM2 p.Val83Met Uncertain significance Single submitter
All CALHM2 variants
Uncertain significance 62
- p.Ala110Val Single submitter ⚠
- p.Ala243Thr Single submitter ⚠
- p.Ala311Val Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg173Pro Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg179Gly Single submitter ⚠
- p.Arg215Cys Single submitter ⚠
- p.Arg224Cys Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg233Pro Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Asn257Ser Single submitter ⚠
- p.Asp314Asn Single submitter ⚠
- p.Cys130Tyr Single submitter ⚠
- p.Gln277Arg Single submitter ⚠
- p.Glu164Asp Single submitter ⚠
- p.Glu236Lys Single submitter ⚠
- p.Glu37Ala Single submitter ⚠
- p.Glu85Gln Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly271Ser Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.Gly62Arg Single submitter ⚠
- p.Gly62Ser Single submitter ⚠
- p.His78Asn Single submitter ⚠
- p.Leu191Phe Single submitter ⚠
- p.Leu198Pro Single submitter ⚠
- p.Leu205Phe Single submitter ⚠
- p.Leu212Phe Single submitter ⚠
- p.Leu212Pro Single submitter ⚠
- p.Leu299Arg Single submitter ⚠
- p.Leu321Phe Single submitter ⚠
- p.Phe100Leu Single submitter ⚠
- p.Phe11Val Single submitter ⚠
- p.Phe148Leu Single submitter ⚠
- p.Phe172Leu Single submitter ⚠
- p.Phe200Leu Single submitter ⚠
- p.Phe267Leu Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Ser184Phe Single submitter ⚠
- p.Thr142Met Single submitter ⚠
- p.Thr272Met Single submitter ⚠
- p.Trp117Cys Single submitter ⚠
- p.Trp220Arg Single submitter ⚠
- p.Trp220Leu Single submitter ⚠
- p.Tyr128His Single submitter ⚠
- p.Val136Met Single submitter ⚠
- p.Val194Leu Single submitter ⚠
- p.Val237Glu Single submitter ⚠
- p.Val269Ala Single submitter ⚠
- p.Val284Ile Single submitter ⚠
- p.Val316Leu Single submitter ⚠
- p.Val83Met Single submitter ⚠