CALHM3 — 68 ClinVar variants
All ClinVar germline CALHM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
4 Likely benign · 64 Uncertain significance
Full CALHM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALHM3 p.Ala108Val Uncertain significance Single submitter
- CALHM3 p.Ala109Thr Uncertain significance Single submitter
- CALHM3 p.Ala168Thr Uncertain significance Single submitter
- CALHM3 p.Ala85Thr Uncertain significance Single submitter
- CALHM3 p.Arg169Gln Uncertain significance Single submitter
- CALHM3 p.Arg174His Uncertain significance Single submitter
- CALHM3 p.Arg174Leu Uncertain significance Single submitter
- CALHM3 p.Arg199Pro Uncertain significance Single submitter
- CALHM3 p.Arg261Gln Uncertain significance Single submitter
- CALHM3 p.Arg267Thr Uncertain significance Single submitter
- CALHM3 p.Arg72Gln Uncertain significance Single submitter
- CALHM3 p.Arg82His Uncertain significance Single submitter
- CALHM3 p.Arg88Gln Uncertain significance Single submitter
- CALHM3 p.Arg88Trp Uncertain significance Single submitter
- CALHM3 p.Asn40His Uncertain significance Single submitter
- CALHM3 p.Asp343Ala Uncertain significance Single submitter
- CALHM3 p.Cys157Arg Uncertain significance Single submitter
- CALHM3 p.Cys23Tyr Uncertain significance Single submitter
- CALHM3 p.Cys99Tyr Uncertain significance Single submitter
- CALHM3 p.Gln207Arg Uncertain significance Single submitter
- CALHM3 p.Gln212His Uncertain significance Single submitter
- CALHM3 p.Glu229Asp Uncertain significance Single submitter
- CALHM3 p.Glu229Gln Uncertain significance Single submitter
- CALHM3 p.Glu269Gln Uncertain significance Single submitter
- CALHM3 p.Glu275Asp Uncertain significance Single submitter
- CALHM3 p.Glu79Lys Uncertain significance Single submitter
- CALHM3 p.Gly323Asp Uncertain significance Single submitter
- CALHM3 p.Gly323Val Uncertain significance Single submitter
- CALHM3 p.Gly67Asp Uncertain significance Single submitter
- CALHM3 p.Gly67Ser Uncertain significance Single submitter
- CALHM3 p.His10Arg Uncertain significance Single submitter
- CALHM3 p.Leu222Pro Uncertain significance Single submitter
- CALHM3 p.Leu226Pro Uncertain significance Single submitter
- CALHM3 p.Leu301Phe Uncertain significance Single submitter
- CALHM3 p.Leu302Gln Uncertain significance Single submitter
- CALHM3 p.Leu338Arg Uncertain significance Single submitter
- CALHM3 p.Leu44Val Uncertain significance Single submitter
- CALHM3 p.Phe11Leu Uncertain significance Single submitter
- CALHM3 p.Pro271Ala Uncertain significance Single submitter
- CALHM3 p.Pro271Ser Uncertain significance Single submitter
- CALHM3 p.Pro310Leu Uncertain significance Single submitter
- CALHM3 p.Ser146Gly Uncertain significance Single submitter
- CALHM3 p.Ser217Gly Uncertain significance Single submitter
- CALHM3 p.Ser339Pro Uncertain significance Single submitter
- CALHM3 p.Thr208Ser Uncertain significance Single submitter
- CALHM3 p.Tyr215Cys Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CALHM3 p.Ala106Val Uncertain significance Single submitter
- CALHM3 p.Ala235Val Uncertain significance Single submitter
- CALHM3 p.Ala248Val Uncertain significance Single submitter
- CALHM3 p.Ala256Thr Uncertain significance Single submitter
- CALHM3 p.Arg199Gly Uncertain significance Single submitter
- CALHM3 p.Arg257Gly Uncertain significance Single submitter
- CALHM3 p.Arg83Gln Uncertain significance Single submitter
- CALHM3 p.Glu269Lys Uncertain significance Single submitter
- CALHM3 p.Glu80Gly Uncertain significance Single submitter
- CALHM3 p.Gly184Ser Uncertain significance Single submitter
- CALHM3 p.Gly262Ser Uncertain significance Single submitter
- CALHM3 p.His245Tyr Uncertain significance Single submitter
- CALHM3 p.Leu301Pro Uncertain significance Single submitter
- CALHM3 p.Leu50Pro Uncertain significance Single submitter
- CALHM3 p.Ser17Leu Uncertain significance Single submitter
- CALHM3 p.Tyr34Cys Uncertain significance Single submitter
- CALHM3 p.Val172Met Uncertain significance Single submitter
- CALHM3 p.Val31Ile Uncertain significance Single submitter
All CALHM3 variants
Likely benign 4
- p.Ala194Val Single submitter
- p.Ala85Ser Single submitter
- p.Gly279Val Single submitter
- p.Thr58Ala Single submitter
Uncertain significance 64
- p.Ala106Val Single submitter ⚠
- p.Ala108Val Single submitter ⚠
- p.Ala109Thr Single submitter ⚠
- p.Ala168Thr Single submitter ⚠
- p.Ala235Val Single submitter ⚠
- p.Ala248Val Single submitter ⚠
- p.Ala256Thr Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg169Gln Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg174Leu Single submitter ⚠
- p.Arg199Gly Single submitter ⚠
- p.Arg199Pro Single submitter ⚠
- p.Arg257Gly Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg267Thr Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Arg88Trp Single submitter ⚠
- p.Asn40His Single submitter ⚠
- p.Asp343Ala Single submitter ⚠
- p.Cys157Arg Single submitter ⚠
- p.Cys23Tyr Single submitter ⚠
- p.Cys99Tyr Single submitter ⚠
- p.Gln207Arg Single submitter ⚠
- p.Gln212His Single submitter ⚠
- p.Glu229Asp Single submitter ⚠
- p.Glu229Gln Single submitter ⚠
- p.Glu269Gln Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu275Asp Single submitter ⚠
- p.Glu79Lys Single submitter ⚠
- p.Glu80Gly Single submitter ⚠
- p.Gly184Ser Single submitter ⚠
- p.Gly262Ser Single submitter ⚠
- p.Gly323Asp Single submitter ⚠
- p.Gly323Val Single submitter ⚠
- p.Gly67Asp Single submitter ⚠
- p.Gly67Ser Single submitter ⚠
- p.His10Arg Single submitter ⚠
- p.His245Tyr Single submitter ⚠
- p.Leu222Pro Single submitter ⚠
- p.Leu226Pro Single submitter ⚠
- p.Leu301Phe Single submitter ⚠
- p.Leu301Pro Single submitter ⚠
- p.Leu302Gln Single submitter ⚠
- p.Leu338Arg Single submitter ⚠
- p.Leu44Val Single submitter ⚠
- p.Leu50Pro Single submitter ⚠
- p.Phe11Leu Single submitter ⚠
- p.Pro271Ala Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Ser146Gly Single submitter ⚠
- p.Ser17Leu Single submitter ⚠
- p.Ser217Gly Single submitter ⚠
- p.Ser339Pro Single submitter ⚠
- p.Thr208Ser Single submitter ⚠
- p.Tyr215Cys Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Val172Met Single submitter ⚠
- p.Val31Ile Single submitter ⚠