CALHM4 — 23 ClinVar variants
All ClinVar germline CALHM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
23 Uncertain significance
Full CALHM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALHM4 p.Ala199Thr Uncertain significance Single submitter
- CALHM4 p.Arg247His Uncertain significance Single submitter
- CALHM4 p.Arg265His Uncertain significance Single submitter
- CALHM4 p.Arg306Gly Uncertain significance Single submitter
- CALHM4 p.Cys209Arg Uncertain significance Single submitter
- CALHM4 p.Cys269Gly Uncertain significance Single submitter
- CALHM4 p.Cys269Ser Uncertain significance Single submitter
- CALHM4 p.Glu228Asp Uncertain significance Single submitter
- CALHM4 p.Gly295Glu Uncertain significance Single submitter
- CALHM4 p.His218Gln Uncertain significance Single submitter
- CALHM4 p.Ile191Thr Uncertain significance Single submitter
- CALHM4 p.Leu251Ile Uncertain significance Single submitter
- CALHM4 p.Lys262Arg Uncertain significance Single submitter
- CALHM4 p.Met245Thr Uncertain significance Single submitter
- CALHM4 p.Phe293Leu Uncertain significance Single submitter
- CALHM4 p.Val261Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CALHM4 p.Arg241Trp Uncertain significance Single submitter
- CALHM4 p.Asp260Val Uncertain significance Single submitter
- CALHM4 p.Cys204Arg Uncertain significance Single submitter
- CALHM4 p.Ser240Phe Uncertain significance Single submitter
- CALHM4 p.Ser240Pro Uncertain significance Single submitter
- CALHM4 p.Thr197Asn Uncertain significance Single submitter
- CALHM4 p.Thr214Ala Uncertain significance Single submitter
All CALHM4 variants
Uncertain significance 23
- p.Ala199Thr Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg306Gly Single submitter ⚠
- p.Asp260Val Single submitter ⚠
- p.Cys204Arg Single submitter ⚠
- p.Cys209Arg Single submitter ⚠
- p.Cys269Gly Single submitter ⚠
- p.Cys269Ser Single submitter ⚠
- p.Glu228Asp Single submitter ⚠
- p.Gly295Glu Single submitter ⚠
- p.His218Gln Single submitter ⚠
- p.Ile191Thr Single submitter ⚠
- p.Leu251Ile Single submitter ⚠
- p.Lys262Arg Single submitter ⚠
- p.Met245Thr Single submitter ⚠
- p.Phe293Leu Single submitter ⚠
- p.Ser240Phe Single submitter ⚠
- p.Ser240Pro Single submitter ⚠
- p.Thr197Asn Single submitter ⚠
- p.Thr214Ala Single submitter ⚠
- p.Val261Ile Single submitter ⚠