CALHM5 — 52 ClinVar variants
All ClinVar germline CALHM5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Likely benign · 51 Uncertain significance
Full CALHM5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALHM5 p.Ala177Val Uncertain significance Single submitter
- CALHM5 p.Ala190Val Uncertain significance Single submitter
- CALHM5 p.Arg202Cys Uncertain significance Single submitter
- CALHM5 p.Arg202His Uncertain significance Single submitter
- CALHM5 p.Arg204Gln Uncertain significance Single submitter
- CALHM5 p.Arg90Ser Uncertain significance Single submitter
- CALHM5 p.Asn168Ile Uncertain significance Single submitter
- CALHM5 p.Asn287Ser Uncertain significance Single submitter
- CALHM5 p.Cys127Arg Uncertain significance Single submitter
- CALHM5 p.Cys158Tyr Uncertain significance Single submitter
- CALHM5 p.Glu152Ala Uncertain significance Single submitter
- CALHM5 p.Gly101Ser Uncertain significance Single submitter
- CALHM5 p.Gly6Arg Uncertain significance Single submitter
- CALHM5 p.Gly6Asp Uncertain significance Single submitter
- CALHM5 p.His277Arg Uncertain significance Single submitter
- CALHM5 p.Leu171Pro Uncertain significance Single submitter
- CALHM5 p.Leu186Pro Uncertain significance Single submitter
- CALHM5 p.Leu196Phe Uncertain significance Single submitter
- CALHM5 p.Leu242Val Uncertain significance Single submitter
- CALHM5 p.Leu289Pro Uncertain significance Single submitter
- CALHM5 p.Leu63Pro Uncertain significance Single submitter
- CALHM5 p.Leu69Pro Uncertain significance Single submitter
- CALHM5 p.Met113Thr Uncertain significance Single submitter
- CALHM5 p.Met129Ile Uncertain significance Single submitter
- CALHM5 p.Pro257Leu Uncertain significance Single submitter
- CALHM5 p.Pro293Leu Uncertain significance Single submitter
- CALHM5 p.Ser130Arg Uncertain significance Single submitter
- CALHM5 p.Ser157Pro Uncertain significance Single submitter
- CALHM5 p.Ser191Cys Uncertain significance Single submitter
- CALHM5 p.Thr104Ala Uncertain significance Single submitter
- CALHM5 p.Tyr98Cys Uncertain significance Single submitter
- CALHM5 p.Val36Ala Uncertain significance Single submitter
- CALHM5 p.Val61Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CALHM5 p.Arg32Ser Uncertain significance Single submitter
- CALHM5 p.Asn121Ser Uncertain significance Single submitter
- CALHM5 p.Asn13Ile Uncertain significance Single submitter
- CALHM5 p.Glu148Gln Uncertain significance Single submitter
- CALHM5 p.Gly159Asp Uncertain significance Single submitter
- CALHM5 p.Leu100Val Uncertain significance Single submitter
- CALHM5 p.Leu115Val Uncertain significance Single submitter
- CALHM5 p.Leu52Arg Uncertain significance Single submitter
- CALHM5 p.Leu62Val Uncertain significance Single submitter
- CALHM5 p.Leu65Pro Likely benign Single submitter
- CALHM5 p.Leu69Met Uncertain significance Single submitter
- CALHM5 p.Ser174Cys Uncertain significance Single submitter
- CALHM5 p.Ser73Leu Uncertain significance Single submitter
- CALHM5 p.Ser73Trp Uncertain significance Single submitter
- CALHM5 p.Thr258Met Uncertain significance Single submitter
- CALHM5 p.Trp150Cys Uncertain significance Single submitter
- CALHM5 p.Trp215Ser Uncertain significance Single submitter
- CALHM5 p.Val109Leu Uncertain significance Single submitter
- CALHM5 p.Val285Gly Uncertain significance Single submitter
All CALHM5 variants
Likely benign 1
- p.Leu65Pro Single submitter ⚠
Uncertain significance 51
- p.Ala177Val Single submitter ⚠
- p.Ala190Val Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg32Ser Single submitter ⚠
- p.Arg90Ser Single submitter ⚠
- p.Asn121Ser Single submitter ⚠
- p.Asn13Ile Single submitter ⚠
- p.Asn168Ile Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Cys127Arg Single submitter ⚠
- p.Cys158Tyr Single submitter ⚠
- p.Glu148Gln Single submitter ⚠
- p.Glu152Ala Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly6Asp Single submitter ⚠
- p.His277Arg Single submitter ⚠
- p.Leu100Val Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu171Pro Single submitter ⚠
- p.Leu186Pro Single submitter ⚠
- p.Leu196Phe Single submitter ⚠
- p.Leu242Val Single submitter ⚠
- p.Leu289Pro Single submitter ⚠
- p.Leu52Arg Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Leu63Pro Single submitter ⚠
- p.Leu69Met Single submitter ⚠
- p.Leu69Pro Single submitter ⚠
- p.Met113Thr Single submitter ⚠
- p.Met129Ile Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Ser130Arg Single submitter ⚠
- p.Ser157Pro Single submitter ⚠
- p.Ser174Cys Single submitter ⚠
- p.Ser191Cys Single submitter ⚠
- p.Ser73Leu Single submitter ⚠
- p.Ser73Trp Single submitter ⚠
- p.Thr104Ala Single submitter ⚠
- p.Thr258Met Single submitter ⚠
- p.Trp150Cys Single submitter ⚠
- p.Trp215Ser Single submitter ⚠
- p.Tyr98Cys Single submitter ⚠
- p.Val109Leu Single submitter ⚠
- p.Val285Gly Single submitter ⚠
- p.Val36Ala Single submitter ⚠
- p.Val61Leu Single submitter ⚠