CALHM6 — 49 ClinVar variants
All ClinVar germline CALHM6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Likely benign · 47 Uncertain significance
Full CALHM6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALHM6 p.Arg144Ser Uncertain significance Single submitter
- CALHM6 p.Arg73Gly Uncertain significance Single submitter
- CALHM6 p.Asn267Ser Uncertain significance Single submitter
- CALHM6 p.Cys155Tyr Uncertain significance Single submitter
- CALHM6 p.Cys89Trp Uncertain significance Single submitter
- CALHM6 p.Gln101Arg Uncertain significance Single submitter
- CALHM6 p.Glu125Gln Uncertain significance Single submitter
- CALHM6 p.His11Asn Uncertain significance Single submitter
- CALHM6 p.His277Pro Uncertain significance Single submitter
- CALHM6 p.Ile187Thr Uncertain significance Single submitter
- CALHM6 p.Leu10Val Uncertain significance Single submitter
- CALHM6 p.Leu150Arg Uncertain significance Single submitter
- CALHM6 p.Leu61Val Uncertain significance Single submitter
- CALHM6 p.Leu66Arg Uncertain significance Single submitter
- CALHM6 p.Lys13Glu Uncertain significance Single submitter
- CALHM6 p.Pro268Leu Uncertain significance Single submitter
- CALHM6 p.Ser145Arg Uncertain significance Single submitter
- CALHM6 p.Ser223Arg Uncertain significance Single submitter
- CALHM6 p.Ser311Arg Uncertain significance Single submitter
- CALHM6 p.Ser44Asn Uncertain significance Single submitter
- CALHM6 p.Thr230Ser Uncertain significance Single submitter
- CALHM6 p.Thr286Ile Uncertain significance Single submitter
- CALHM6 p.Trp113Arg Uncertain significance Single submitter
- CALHM6 p.Tyr68Cys Uncertain significance Single submitter
- CALHM6 p.Val153Leu Uncertain significance Single submitter
- CALHM6 p.Val176Leu Uncertain significance Single submitter
- CALHM6 p.Val300Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CALHM6 p.Ala233Val Uncertain significance Single submitter
- CALHM6 p.Ala36Asp Uncertain significance Single submitter
- CALHM6 p.Ala62Ser Uncertain significance Single submitter
- CALHM6 p.Asn143Lys Uncertain significance Single submitter
- CALHM6 p.Asn236Ser Uncertain significance Single submitter
- CALHM6 p.Glu217Gly Uncertain significance Single submitter
- CALHM6 p.Glu256Gly Uncertain significance Single submitter
- CALHM6 p.Glu2Lys Uncertain significance Single submitter
- CALHM6 p.Gly52Ser Uncertain significance Single submitter
- CALHM6 p.Leu111Pro Uncertain significance Single submitter
- CALHM6 p.Leu276Phe Uncertain significance Single submitter
- CALHM6 p.Leu49Pro Uncertain significance Single submitter
- CALHM6 p.Leu49Val Uncertain significance Single submitter
- CALHM6 p.Phe39Leu Uncertain significance Single submitter
- CALHM6 p.Phe64Leu Uncertain significance Single submitter
- CALHM6 p.Pro154Arg Uncertain significance Single submitter
- CALHM6 p.Pro154Leu Uncertain significance Single submitter
- CALHM6 p.Ser145Cys Uncertain significance Single submitter
- CALHM6 p.Thr79Ile Uncertain significance Single submitter
- CALHM6 p.Val69Met Uncertain significance Single submitter
All CALHM6 variants
Likely benign 2
- p.Asn156Lys Single submitter
- p.Pro110= Single submitter
Uncertain significance 47
- p.Ala233Val Single submitter ⚠
- p.Ala36Asp Single submitter ⚠
- p.Ala62Ser Single submitter ⚠
- p.Arg144Ser Single submitter ⚠
- p.Arg73Gly Single submitter ⚠
- p.Asn143Lys Single submitter ⚠
- p.Asn236Ser Single submitter ⚠
- p.Asn267Ser Single submitter ⚠
- p.Cys155Tyr Single submitter ⚠
- p.Cys89Trp Single submitter ⚠
- p.Gln101Arg Single submitter ⚠
- p.Glu125Gln Single submitter ⚠
- p.Glu217Gly Single submitter ⚠
- p.Glu256Gly Single submitter ⚠
- p.Glu2Lys Single submitter ⚠
- p.Gly52Ser Single submitter ⚠
- p.His11Asn Single submitter ⚠
- p.His277Pro Single submitter ⚠
- p.Ile187Thr Single submitter ⚠
- p.Leu10Val Single submitter ⚠
- p.Leu111Pro Single submitter ⚠
- p.Leu150Arg Single submitter ⚠
- p.Leu276Phe Single submitter ⚠
- p.Leu49Pro Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Leu66Arg Single submitter ⚠
- p.Lys13Glu Single submitter ⚠
- p.Phe39Leu Single submitter ⚠
- p.Phe64Leu Single submitter ⚠
- p.Pro154Arg Single submitter ⚠
- p.Pro154Leu Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Ser145Arg Single submitter ⚠
- p.Ser145Cys Single submitter ⚠
- p.Ser223Arg Single submitter ⚠
- p.Ser311Arg Single submitter ⚠
- p.Ser44Asn Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Trp113Arg Single submitter ⚠
- p.Tyr68Cys Single submitter ⚠
- p.Val153Leu Single submitter ⚠
- p.Val176Leu Single submitter ⚠
- p.Val300Ile Single submitter ⚠
- p.Val69Met Single submitter ⚠