CALML4 — 30 ClinVar variants
All ClinVar germline CALML4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
4 Likely benign · 26 Uncertain significance
Full CALML4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALML4 c.-23C>G Uncertain significance Single submitter
- CALML4 c.-69G>A Uncertain significance Single submitter
- CALML4 p.Arg107Trp Uncertain significance Single submitter
- CALML4 p.Asn134Asp Uncertain significance Single submitter
- CALML4 p.Asp94Asn Uncertain significance Single submitter
- CALML4 p.Gln50Arg Uncertain significance Single submitter
- CALML4 p.Gln79Glu Uncertain significance Single submitter
- CALML4 p.Gln7Glu Uncertain significance Single submitter
- CALML4 p.Glu115Lys Uncertain significance Single submitter
- CALML4 p.Glu121Asp Uncertain significance Single submitter
- CALML4 p.Glu121Gln Uncertain significance Single submitter
- CALML4 p.Glu85Gln Uncertain significance Single submitter
- CALML4 p.Gly57Arg Uncertain significance Single submitter
- CALML4 p.Leu40Arg Uncertain significance Single submitter
- CALML4 p.Leu88Val Uncertain significance Single submitter
- CALML4 p.Met90Thr Uncertain significance Single submitter
- CALML4 p.Pro44Leu Uncertain significance Single submitter
- CALML4 p.Thr55Ser Uncertain significance Single submitter
- CALML4 p.Tyr20Asp Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CALML4 p.Arg151Trp Uncertain significance Single submitter
- CALML4 p.Asp8Tyr Uncertain significance Single submitter
- CALML4 p.Ile131Leu Uncertain significance Single submitter
- CALML4 p.Ile131Phe Uncertain significance Single submitter
- CALML4 p.Leu87Val Uncertain significance Single submitter
- CALML4 p.Lys145Asn Uncertain significance Single submitter
- CALML4 p.Thr68Ile Uncertain significance Single submitter
All CALML4 variants
Likely benign 4
- c.-45G>A Single submitter
- p.Asp105Glu Single submitter
- p.Asp130Gly Single submitter
- p.Val101Ile Single submitter
Uncertain significance 26
- c.-23C>G Single submitter ⚠
- c.-69G>A Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Arg151Trp Single submitter ⚠
- p.Asn134Asp Single submitter ⚠
- p.Asp8Tyr Single submitter ⚠
- p.Asp94Asn Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Gln79Glu Single submitter ⚠
- p.Gln7Glu Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu121Gln Single submitter ⚠
- p.Glu85Gln Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.Ile131Leu Single submitter ⚠
- p.Ile131Phe Single submitter ⚠
- p.Leu40Arg Single submitter ⚠
- p.Leu87Val Single submitter ⚠
- p.Leu88Val Single submitter ⚠
- p.Lys145Asn Single submitter ⚠
- p.Met90Thr Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Thr55Ser Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Tyr20Asp Single submitter ⚠