CALML5 — 19 ClinVar variants
All ClinVar germline CALML5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Likely benign · 17 Uncertain significance
Full CALML5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 13
The independent predictors disagree with each other — read with care.
- CALML5 p.Ala106Gly Uncertain significance Single submitter
- CALML5 p.Ala47Thr Uncertain significance Single submitter
- CALML5 p.Ala89Gly Uncertain significance Single submitter
- CALML5 p.Arg105Pro Uncertain significance Single submitter
- CALML5 p.Arg133Leu Uncertain significance Single submitter
- CALML5 p.Arg133Trp Uncertain significance Single submitter
- CALML5 p.Asp23Glu Uncertain significance Single submitter
- CALML5 p.Glu117Gln Uncertain significance Single submitter
- CALML5 p.Glu81Gln Likely benign Single submitter
- CALML5 p.Gly111Arg Uncertain significance Single submitter
- CALML5 p.Leu52Phe Uncertain significance Single submitter
- CALML5 p.Met107Lys Uncertain significance Single submitter
- CALML5 p.Met142Arg Uncertain significance Single submitter
All CALML5 variants
Likely benign 2
- p.Ala73Val Single submitter
- p.Glu81Gln Single submitter ⚠
Uncertain significance 17
- p.Ala106Gly Single submitter ⚠
- p.Ala16Thr Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Ala89Gly Single submitter ⚠
- p.Arg105Pro Single submitter ⚠
- p.Arg133Leu Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Asp23Glu Single submitter ⚠
- p.Asp59Ala Single submitter ⚠
- p.Gln12Arg Single submitter ⚠
- p.Glu117Gln Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Leu52Phe Single submitter ⚠
- p.Met107Lys Single submitter ⚠
- p.Met142Arg Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val134Met Single submitter ⚠