CALML6 — 26 ClinVar variants
All ClinVar germline CALML6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
3 Benign · 23 Uncertain significance
Full CALML6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALML6 p.Asn144Asp Uncertain significance Single submitter
- CALML6 p.Glu47Lys Uncertain significance Single submitter
- CALML6 p.Glu52Lys Uncertain significance Single submitter
- CALML6 p.His102Gln Uncertain significance Single submitter
- CALML6 p.Leu9Arg Uncertain significance Single submitter
- CALML6 p.Lys36Glu Uncertain significance Single submitter
- CALML6 p.Val41Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CALML6 p.Gly87Ala Benign Multiple submitters
- CALML6 p.Asp128Tyr Uncertain significance Single submitter
- CALML6 p.Gln34Arg Uncertain significance Single submitter
- CALML6 p.Glu111Gln Uncertain significance Single submitter
- CALML6 p.Glu145Gln Uncertain significance Single submitter
- CALML6 p.Gly159Ala Uncertain significance Single submitter
- CALML6 p.Gly49Cys Uncertain significance Single submitter
- CALML6 p.Gly87Val Uncertain significance Single submitter
- CALML6 p.Gly99Arg Uncertain significance Single submitter
- CALML6 p.Leu143Phe Uncertain significance Single submitter
- CALML6 p.Leu65Met Uncertain significance Single submitter
- CALML6 p.Lys157Arg Uncertain significance Single submitter
- CALML6 p.Lys71Gln Uncertain significance Single submitter
- CALML6 p.Lys79Asn Uncertain significance Single submitter
- CALML6 p.Met151Ile Uncertain significance Single submitter
- CALML6 p.Met62Val Uncertain significance Single submitter
- CALML6 p.Thr55Met Uncertain significance Single submitter
All CALML6 variants
Benign 3
- p.Ala96= Multiple submitters
- p.Gly87Ala Multiple submitters ⚠
- p.Pro69= Single submitter
Uncertain significance 23
- p.Asn144Asp Single submitter ⚠
- p.Asp128Tyr Single submitter ⚠
- p.Gln34Arg Single submitter ⚠
- p.Glu111Gln Single submitter ⚠
- p.Glu145Gln Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Glu52Lys Single submitter ⚠
- p.Gly159Ala Single submitter ⚠
- p.Gly49Cys Single submitter ⚠
- p.Gly87Val Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His102Gln Single submitter ⚠
- p.Leu143Phe Single submitter ⚠
- p.Leu65Met Single submitter ⚠
- p.Leu9Arg Single submitter ⚠
- p.Lys157Arg Single submitter ⚠
- p.Lys36Glu Single submitter ⚠
- p.Lys71Gln Single submitter ⚠
- p.Lys79Asn Single submitter ⚠
- p.Met151Ile Single submitter ⚠
- p.Met62Val Single submitter ⚠
- p.Thr55Met Single submitter ⚠
- p.Val41Ile Single submitter ⚠