CALY — 32 ClinVar variants
All ClinVar germline CALY variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 31 Uncertain significance
Full CALY gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALY p.Ala150Asp Uncertain significance Single submitter
- CALY p.Ala187Glu Uncertain significance Single submitter
- CALY p.Ala23Pro Uncertain significance Single submitter
- CALY p.Ala86Ser Uncertain significance Single submitter
- CALY p.Ala86Thr Uncertain significance Single submitter
- CALY p.Ala94Val Uncertain significance Single submitter
- CALY p.Arg120Trp Uncertain significance Single submitter
- CALY p.Arg81His Uncertain significance Single submitter
- CALY p.Cys6Tyr Uncertain significance Single submitter
- CALY p.Cys98Arg Uncertain significance Single submitter
- CALY p.Gln19His Uncertain significance Single submitter
- CALY p.Glu190Gln Uncertain significance Single submitter
- CALY p.Glu78Lys Uncertain significance Single submitter
- CALY p.Gly5Ser Uncertain significance Single submitter
- CALY p.Ile148Met Uncertain significance Single submitter
- CALY p.Lys201Arg Uncertain significance Single submitter
- CALY p.Pro192Arg Uncertain significance Single submitter
- CALY p.Pro195Gln Uncertain significance Single submitter
- CALY p.Pro214Thr Uncertain significance Single submitter
- CALY p.Ser26Thr Uncertain significance Single submitter
- CALY p.Ser7Ile Uncertain significance Single submitter
- CALY p.Tyr169Asn Uncertain significance Single submitter
- CALY p.Val99Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CALY p.Arg176Cys Uncertain significance Single submitter
- CALY p.Arg205Trp Uncertain significance Single submitter
- CALY p.Ile48Phe Uncertain significance Single submitter
- CALY p.Met102Thr Uncertain significance Single submitter
- CALY p.Phe8Ser Uncertain significance Single submitter
- CALY p.Ser143Arg Uncertain significance Single submitter
- CALY p.Ser154Arg Uncertain significance Single submitter
- CALY p.Val46Met Uncertain significance Single submitter
All CALY variants
Likely benign 1
- p.Ile123= Single submitter
Uncertain significance 31
- p.Ala150Asp Single submitter ⚠
- p.Ala187Glu Single submitter ⚠
- p.Ala23Pro Single submitter ⚠
- p.Ala86Ser Single submitter ⚠
- p.Ala86Thr Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Cys6Tyr Single submitter ⚠
- p.Cys98Arg Single submitter ⚠
- p.Gln19His Single submitter ⚠
- p.Glu190Gln Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.Ile148Met Single submitter ⚠
- p.Ile48Phe Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Met102Thr Single submitter ⚠
- p.Phe8Ser Single submitter ⚠
- p.Pro192Arg Single submitter ⚠
- p.Pro195Gln Single submitter ⚠
- p.Pro214Thr Single submitter ⚠
- p.Ser143Arg Single submitter ⚠
- p.Ser154Arg Single submitter ⚠
- p.Ser26Thr Single submitter ⚠
- p.Ser7Ile Single submitter ⚠
- p.Tyr169Asn Single submitter ⚠
- p.Val46Met Single submitter ⚠
- p.Val99Met Single submitter ⚠