CAMK1 — 57 ClinVar variants
All ClinVar germline CAMK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
3 Likely benign · 54 Uncertain significance
Full CAMK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAMK1 p.Ser32Leu Uncertain significance Multiple submitters
- CAMK1 p.Ala186Val Uncertain significance Single submitter
- CAMK1 p.Ala342Ser Uncertain significance Single submitter
- CAMK1 p.Ala47Thr Uncertain significance Single submitter
- CAMK1 p.Arg140Trp Uncertain significance Single submitter
- CAMK1 p.Arg352Gln Uncertain significance Single submitter
- CAMK1 p.Arg9Gly Uncertain significance Single submitter
- CAMK1 p.Asp21Asn Uncertain significance Single submitter
- CAMK1 p.Asp223Ala Uncertain significance Single submitter
- CAMK1 p.Asp39Gly Uncertain significance Single submitter
- CAMK1 p.Gln369His Uncertain significance Single submitter
- CAMK1 p.Glu14Lys Uncertain significance Single submitter
- CAMK1 p.Glu188Asp Uncertain significance Single submitter
- CAMK1 p.Gly101Arg Uncertain significance Single submitter
- CAMK1 p.Gly111Val Uncertain significance Single submitter
- CAMK1 p.Gly327Val Uncertain significance Single submitter
- CAMK1 p.His139Gln Uncertain significance Single submitter
- CAMK1 p.His287Gln Uncertain significance Single submitter
- CAMK1 p.Ile137Leu Uncertain significance Single submitter
- CAMK1 p.Ile276Thr Uncertain significance Single submitter
- CAMK1 p.Ile78Thr Uncertain significance Single submitter
- CAMK1 p.Met316Ile Uncertain significance Single submitter
- CAMK1 p.Met316Val Uncertain significance Single submitter
- CAMK1 p.Pro182Leu Uncertain significance Single submitter
- CAMK1 p.Pro345Ala Uncertain significance Single submitter
- CAMK1 p.Pro345Leu Uncertain significance Single submitter
- CAMK1 p.Pro358Leu Uncertain significance Single submitter
- CAMK1 p.Pro367Ser Uncertain significance Single submitter
- CAMK1 p.Ser119Thr Uncertain significance Single submitter
- CAMK1 p.Thr28Pro Uncertain significance Single submitter
- CAMK1 p.Tyr92His Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CAMK1 p.Arg116Gln Uncertain significance Single submitter
- CAMK1 p.Arg116Trp Uncertain significance Single submitter
- CAMK1 p.Arg254Gln Uncertain significance Single submitter
- CAMK1 p.Arg254Leu Uncertain significance Single submitter
- CAMK1 p.Arg254Trp Uncertain significance Single submitter
- CAMK1 p.Arg314Gln Uncertain significance Single submitter
- CAMK1 p.Asn77Ser Uncertain significance Single submitter
- CAMK1 p.Asp279His Uncertain significance Single submitter
- CAMK1 p.Asp82Gly Uncertain significance Single submitter
- CAMK1 p.Cys349Tyr Uncertain significance Single submitter
- CAMK1 p.Glu228Ala Uncertain significance Single submitter
- CAMK1 p.Glu228Lys Uncertain significance Single submitter
- CAMK1 p.Glu234Lys Uncertain significance Single submitter
- CAMK1 p.Glu86Lys Uncertain significance Single submitter
- CAMK1 p.Ile19Asn Uncertain significance Single submitter
- CAMK1 p.Lys74Gln Uncertain significance Single submitter
- CAMK1 p.Phe265Ser Uncertain significance Single submitter
- CAMK1 p.Pro76Leu Uncertain significance Single submitter
- CAMK1 p.Ser151Gly Uncertain significance Single submitter
- CAMK1 p.Ser291Cys Uncertain significance Single submitter
- CAMK1 p.Ser99Leu Uncertain significance Single submitter
- CAMK1 p.Thr331Met Uncertain significance Single submitter
- CAMK1 p.Val341Met Uncertain significance Single submitter
All CAMK1 variants
Uncertain significance 54
- p.Ser32Leu Multiple submitters ⚠
- p.Ala186Val Single submitter ⚠
- p.Ala342Ser Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg254Leu Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg314Gln Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Asn77Ser Single submitter ⚠
- p.Asp21Asn Single submitter ⚠
- p.Asp223Ala Single submitter ⚠
- p.Asp279His Single submitter ⚠
- p.Asp39Gly Single submitter ⚠
- p.Asp82Gly Single submitter ⚠
- p.Cys349Tyr Single submitter ⚠
- p.Gln369His Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu188Asp Single submitter ⚠
- p.Glu228Ala Single submitter ⚠
- p.Glu228Lys Single submitter ⚠
- p.Glu234Lys Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly101Arg Single submitter ⚠
- p.Gly111Val Single submitter ⚠
- p.Gly327Val Single submitter ⚠
- p.His139Gln Single submitter ⚠
- p.His287Gln Single submitter ⚠
- p.Ile137Leu Single submitter ⚠
- p.Ile19Asn Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Ile78Thr Single submitter ⚠
- p.Lys74Gln Single submitter ⚠
- p.Met316Ile Single submitter ⚠
- p.Met316Val Single submitter ⚠
- p.Phe265Ser Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro345Ala Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Pro367Ser Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser119Thr Single submitter ⚠
- p.Ser151Gly Single submitter ⚠
- p.Ser291Cys Single submitter ⚠
- p.Ser99Leu Single submitter ⚠
- p.Thr28Pro Single submitter ⚠
- p.Thr331Met Single submitter ⚠
- p.Tyr92His Single submitter ⚠
- p.Val341Met Single submitter ⚠