CAMKK1 — 77 ClinVar variants
All ClinVar germline CAMKK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
3 Likely benign · 74 Uncertain significance
Full CAMKK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAMKK1 p.Ala103Thr Uncertain significance Single submitter
- CAMKK1 p.Ala187Pro Uncertain significance Single submitter
- CAMKK1 p.Ala222Thr Uncertain significance Single submitter
- CAMKK1 p.Ala315Thr Uncertain significance Single submitter
- CAMKK1 p.Ala360Thr Uncertain significance Single submitter
- CAMKK1 p.Ala467Glu Uncertain significance Single submitter
- CAMKK1 p.Arg13Gln Uncertain significance Single submitter
- CAMKK1 p.Arg173Cys Uncertain significance Single submitter
- CAMKK1 p.Arg468Gln Uncertain significance Single submitter
- CAMKK1 p.Arg65Gln Uncertain significance Single submitter
- CAMKK1 p.Arg78Gln Uncertain significance Single submitter
- CAMKK1 p.Asn147Ser Uncertain significance Single submitter
- CAMKK1 p.Asn225Ser Uncertain significance Single submitter
- CAMKK1 p.Asp11Gly Uncertain significance Single submitter
- CAMKK1 p.Asp121Glu Uncertain significance Single submitter
- CAMKK1 p.Asp231Asn Uncertain significance Single submitter
- CAMKK1 p.Asp24Asn Uncertain significance Single submitter
- CAMKK1 p.Asp356Asn Uncertain significance Single submitter
- CAMKK1 p.Cys243Ser Uncertain significance Single submitter
- CAMKK1 p.Glu374Asp Uncertain significance Single submitter
- CAMKK1 p.Glu414Lys Uncertain significance Single submitter
- CAMKK1 p.Glu422Asp Uncertain significance Single submitter
- CAMKK1 p.Gly140Ser Uncertain significance Single submitter
- CAMKK1 p.Gly295Ser Uncertain significance Single submitter
- CAMKK1 p.Gly331Ala Uncertain significance Single submitter
- CAMKK1 p.Gly485Glu Uncertain significance Single submitter
- CAMKK1 p.Gly487Arg Uncertain significance Single submitter
- CAMKK1 p.Gly489Arg Uncertain significance Single submitter
- CAMKK1 p.His153Tyr Uncertain significance Single submitter
- CAMKK1 p.His406Tyr Uncertain significance Single submitter
- CAMKK1 p.Ile386Met Uncertain significance Single submitter
- CAMKK1 p.Leu361Phe Uncertain significance Single submitter
- CAMKK1 p.Lys277Asn Uncertain significance Single submitter
- CAMKK1 p.Lys435Asn Uncertain significance Single submitter
- CAMKK1 p.Lys483Gln Uncertain significance Single submitter
- CAMKK1 p.Phe486Leu Uncertain significance Single submitter
- CAMKK1 p.Pro369Ser Uncertain significance Single submitter
- CAMKK1 p.Pro44Ala Uncertain significance Single submitter
- CAMKK1 p.Pro45Arg Uncertain significance Single submitter
- CAMKK1 p.Pro46Arg Uncertain significance Single submitter
- CAMKK1 p.Pro5Thr Uncertain significance Single submitter
- CAMKK1 p.Ser100Thr Uncertain significance Single submitter
- CAMKK1 p.Ser379Ile Uncertain significance Single submitter
- CAMKK1 p.Ser57Thr Uncertain significance Single submitter
- CAMKK1 p.Ser97Gly Uncertain significance Single submitter
- CAMKK1 p.Val20Met Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CAMKK1 p.Ala22Val Uncertain significance Single submitter
- CAMKK1 p.Ala360Val Uncertain significance Single submitter
- CAMKK1 p.Arg195Gln Uncertain significance Single submitter
- CAMKK1 p.Arg253Cys Uncertain significance Single submitter
- CAMKK1 p.Arg253His Uncertain significance Single submitter
- CAMKK1 p.Arg457His Uncertain significance Single submitter
- CAMKK1 p.Arg47Gln Uncertain significance Single submitter
- CAMKK1 p.Arg65Trp Uncertain significance Single submitter
- CAMKK1 p.Cys243Arg Uncertain significance Single submitter
- CAMKK1 p.Glu240Ala Uncertain significance Single submitter
- CAMKK1 p.Glu240Gly Uncertain significance Single submitter
- CAMKK1 p.Glu380Lys Uncertain significance Single submitter
- CAMKK1 p.Glu381Lys Uncertain significance Single submitter
- CAMKK1 p.Glu395Gln Uncertain significance Single submitter
- CAMKK1 p.Gly413Arg Uncertain significance Single submitter
- CAMKK1 p.His112Tyr Uncertain significance Single submitter
- CAMKK1 p.His288Gln Uncertain significance Single submitter
- CAMKK1 p.Lys366Glu Uncertain significance Single submitter
- CAMKK1 p.Pro407Ser Uncertain significance Single submitter
- CAMKK1 p.Ser67Asn Uncertain significance Single submitter
- CAMKK1 p.Thr310Met Uncertain significance Single submitter
- CAMKK1 p.Thr396Ala Uncertain significance Single submitter
- CAMKK1 p.Trp444Cys Uncertain significance Single submitter
- CAMKK1 p.Val123Met Uncertain significance Single submitter
- CAMKK1 p.Val341Ile Uncertain significance Single submitter
- CAMKK1 p.Val347Ala Uncertain significance Single submitter
- CAMKK1 p.Val426Met Uncertain significance Single submitter
- CAMKK1 p.Val450Leu Uncertain significance Single submitter
All CAMKK1 variants
Likely benign 3
- p.Pro394= Single submitter
- p.Thr310= Single submitter
- p.Val272Ile Single submitter
Uncertain significance 74
- p.Ala103Thr Single submitter ⚠
- p.Ala187Pro Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala315Thr Single submitter ⚠
- p.Ala360Thr Single submitter ⚠
- p.Ala360Val Single submitter ⚠
- p.Ala467Glu Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg195Gln Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg457His Single submitter ⚠
- p.Arg468Gln Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg65Trp Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asn147Ser Single submitter ⚠
- p.Asn225Ser Single submitter ⚠
- p.Asp11Gly Single submitter ⚠
- p.Asp121Glu Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Asp24Asn Single submitter ⚠
- p.Asp356Asn Single submitter ⚠
- p.Cys243Arg Single submitter ⚠
- p.Cys243Ser Single submitter ⚠
- p.Glu240Ala Single submitter ⚠
- p.Glu240Gly Single submitter ⚠
- p.Glu374Asp Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu381Lys Single submitter ⚠
- p.Glu395Gln Single submitter ⚠
- p.Glu414Lys Single submitter ⚠
- p.Glu422Asp Single submitter ⚠
- p.Gly140Ser Single submitter ⚠
- p.Gly295Ser Single submitter ⚠
- p.Gly331Ala Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.Gly485Glu Single submitter ⚠
- p.Gly487Arg Single submitter ⚠
- p.Gly489Arg Single submitter ⚠
- p.His112Tyr Single submitter ⚠
- p.His153Tyr Single submitter ⚠
- p.His288Gln Single submitter ⚠
- p.His406Tyr Single submitter ⚠
- p.Ile386Met Single submitter ⚠
- p.Leu361Phe Single submitter ⚠
- p.Lys277Asn Single submitter ⚠
- p.Lys366Glu Single submitter ⚠
- p.Lys435Asn Single submitter ⚠
- p.Lys483Gln Single submitter ⚠
- p.Phe486Leu Single submitter ⚠
- p.Pro369Ser Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Pro44Ala Single submitter ⚠
- p.Pro45Arg Single submitter ⚠
- p.Pro46Arg Single submitter ⚠
- p.Pro5Thr Single submitter ⚠
- p.Ser100Thr Single submitter ⚠
- p.Ser379Ile Single submitter ⚠
- p.Ser57Thr Single submitter ⚠
- p.Ser67Asn Single submitter ⚠
- p.Ser97Gly Single submitter ⚠
- p.Thr310Met Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Trp444Cys Single submitter ⚠
- p.Val123Met Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val341Ile Single submitter ⚠
- p.Val347Ala Single submitter ⚠
- p.Val426Met Single submitter ⚠
- p.Val450Leu Single submitter ⚠