CAMKK2 — 79 ClinVar variants
All ClinVar germline CAMKK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
7 Benign · 9 Likely benign · 63 Uncertain significance
Full CAMKK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAMKK2 p.Ala15Val Uncertain significance Single submitter
- CAMKK2 p.Arg203Trp Uncertain significance Single submitter
- CAMKK2 p.Arg227Lys Uncertain significance Single submitter
- CAMKK2 p.Arg494Cys Uncertain significance Single submitter
- CAMKK2 p.Arg537Gln Uncertain significance Single submitter
- CAMKK2 p.Arg548Ser Uncertain significance Single submitter
- CAMKK2 p.Arg72Gln Uncertain significance Single submitter
- CAMKK2 p.Arg91Gln Uncertain significance Single submitter
- CAMKK2 p.Arg97His Uncertain significance Single submitter
- CAMKK2 p.Arg97Leu Uncertain significance Single submitter
- CAMKK2 p.Asn317Ser Uncertain significance Single submitter
- CAMKK2 p.Asp18Asn Uncertain significance Single submitter
- CAMKK2 p.Asp414Asn Uncertain significance Single submitter
- CAMKK2 p.Asp77Asn Uncertain significance Single submitter
- CAMKK2 p.Cys34Arg Uncertain significance Single submitter
- CAMKK2 p.Cys561Gly Uncertain significance Single submitter
- CAMKK2 p.Glu59Lys Uncertain significance Single submitter
- CAMKK2 p.Gly107Arg Uncertain significance Single submitter
- CAMKK2 p.Gly155Cys Uncertain significance Single submitter
- CAMKK2 p.Gly222Val Uncertain significance Single submitter
- CAMKK2 p.Gly22Asp Uncertain significance Single submitter
- CAMKK2 p.Gly549Arg Uncertain significance Single submitter
- CAMKK2 p.His449Arg Uncertain significance Single submitter
- CAMKK2 p.Lys520Asn Uncertain significance Single submitter
- CAMKK2 p.Met391Leu Uncertain significance Single submitter
- CAMKK2 p.Met585Val Uncertain significance Single submitter
- CAMKK2 p.Pro144Leu Uncertain significance Single submitter
- CAMKK2 p.Pro16Leu Uncertain significance Single submitter
- CAMKK2 p.Pro274Arg Uncertain significance Single submitter
- CAMKK2 p.Pro568Ala Uncertain significance Single submitter
- CAMKK2 p.Pro570Leu Uncertain significance Single submitter
- CAMKK2 p.Pro573Ser Uncertain significance Single submitter
- CAMKK2 p.Ser10Arg Uncertain significance Single submitter
- CAMKK2 p.Thr447Arg Uncertain significance Single submitter
- CAMKK2 p.Val131Ile Uncertain significance Single submitter
- CAMKK2 p.Val348Leu Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CAMKK2 p.Arg13Trp Uncertain significance Single submitter
- CAMKK2 p.Arg142Gln Uncertain significance Single submitter
- CAMKK2 p.Arg143Gln Uncertain significance Single submitter
- CAMKK2 p.Arg143Trp Uncertain significance Single submitter
- CAMKK2 p.Arg214Gln Uncertain significance Single submitter
- CAMKK2 p.Arg290His Uncertain significance Single submitter
- CAMKK2 p.Arg38Trp Uncertain significance Single submitter
- CAMKK2 p.Arg425Cys Uncertain significance Single submitter
- CAMKK2 p.Arg494His Uncertain significance Single submitter
- CAMKK2 p.Arg505Trp Uncertain significance Single submitter
- CAMKK2 p.Arg72Trp Uncertain significance Single submitter
- CAMKK2 p.Asn247Ser Uncertain significance Single submitter
- CAMKK2 p.Asn430Lys Uncertain significance Single submitter
- CAMKK2 p.Cys34Tyr Uncertain significance Single submitter
- CAMKK2 p.Glu29Lys Uncertain significance Single submitter
- CAMKK2 p.Glu459Lys Uncertain significance Single submitter
- CAMKK2 p.Glu468Ala Uncertain significance Single submitter
- CAMKK2 p.Glu57Lys Uncertain significance Single submitter
- CAMKK2 p.His93Tyr Uncertain significance Single submitter
- CAMKK2 p.Ile230Thr Uncertain significance Single submitter
- CAMKK2 p.Pro124Leu Uncertain significance Single submitter
- CAMKK2 p.Pro130His Uncertain significance Single submitter
- CAMKK2 p.Ser125Phe Uncertain significance Single submitter
- CAMKK2 p.Ser129Leu Uncertain significance Single submitter
- CAMKK2 p.Thr154Met Uncertain significance Single submitter
- CAMKK2 p.Val151Ile Uncertain significance Single submitter
All CAMKK2 variants
Benign 7
Likely benign 9
- p.Ala554= Single submitter
- p.Arg23Gly Single submitter
- p.Arg38Gln Single submitter
- p.Arg580Gln Single submitter
- p.Leu579Pro Single submitter
- p.Phe267= Single submitter
- p.Pro455= Single submitter
- p.Pro547= Single submitter
- p.Pro581Leu Single submitter
Uncertain significance 63
- p.Ala15Val Single submitter ⚠
- p.Arg13Trp Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg227Lys Single submitter ⚠
- p.Arg290His Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Arg425Cys Single submitter ⚠
- p.Arg494Cys Single submitter ⚠
- p.Arg494His Single submitter ⚠
- p.Arg505Trp Single submitter ⚠
- p.Arg537Gln Single submitter ⚠
- p.Arg548Ser Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Arg97Leu Single submitter ⚠
- p.Asn247Ser Single submitter ⚠
- p.Asn317Ser Single submitter ⚠
- p.Asn430Lys Single submitter ⚠
- p.Asp18Asn Single submitter ⚠
- p.Asp414Asn Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Cys34Arg Single submitter ⚠
- p.Cys34Tyr Single submitter ⚠
- p.Cys561Gly Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu459Lys Single submitter ⚠
- p.Glu468Ala Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly107Arg Single submitter ⚠
- p.Gly155Cys Single submitter ⚠
- p.Gly222Val Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly549Arg Single submitter ⚠
- p.His449Arg Single submitter ⚠
- p.His93Tyr Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Lys520Asn Single submitter ⚠
- p.Met391Leu Single submitter ⚠
- p.Met585fs Single submitter
- p.Met585Val Single submitter ⚠
- p.Pro124Leu Single submitter ⚠
- p.Pro130His Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro274Arg Single submitter ⚠
- p.Pro568Ala Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Pro573Ser Single submitter ⚠
- p.Ser10Arg Single submitter ⚠
- p.Ser125Phe Single submitter ⚠
- p.Ser129Leu Single submitter ⚠
- p.Thr154Met Single submitter ⚠
- p.Thr447Arg Single submitter ⚠
- p.Val131Ile Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val348Leu Single submitter ⚠